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Patent # Description
2019/0134079 BI-FUNCTIONAL CO-POLYMER USE FOR OPHTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS
The invention contemplates a copolymer which is a graft or block copolymer useful to change the ocular surface temperature and other characteristics of...
2019/0134078 POLYMERIC TREATMENT COMPOSITIONS
Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the...
2019/0134077 PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic...
2019/0134076 HCL-BINDING COMPOSITIONS FOR AND METHODS OF TREATING ACID-BASE DISORDERS
Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical...
2019/0134075 PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION
Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical...
2019/0134074 LIPONUCLEOTIDE-BASED THERAPY FOR ARDS
Compositions and method are therefore disclosed for treating ARDS. In particular, disclosed a composition that contains one, two, or more cytidine diphosphate...
2019/0134073 METHODS AND PHARMACEUTICAL COMPOSITIONS OF THE TREATMENT OF AUTISTIC SYNDROME DISORDERS
The present invention relates to a method for the treatment of an autistic syndrome disorder comprising administering to a subject in need thereof an effective...
2019/0134072 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The present invention relates to certain SGLT-2 inhibitors for treating, preventing, protecting against and/or delaying the progression of chronic kidney...
2019/0134071 COMPOSITIONS AND METHODS FOR PROTECTING ORGANS FROM ISCHEMIA/REPERFUSION INJURY ASSOCIATED WITH TRANSPLANTATION
The invention provides compositions and methods for protecting organs, such as lungs, from injury associated with transplantation. Specifically, the invention...
2019/0134070 Methods for Improving Drug Treatments in Mammals
An improved method for identifying the size, shape and duration of drug exposure necessary to improve drug treatment in a subject with a bacterial infection....
2019/0134069 USE OF THYROID BETA-AGONISTS
Methods useful for treating X-linked adrenoleukodystrophy are provided.
2019/0134068 LIPOLYTIC COMPOSITION CONTAINING PHOSPHOCHOLINE DERIVATIVES
The present invention provides a composition for lipolysis, for example a pharmaceutical composition for preventing or treating obesity including localized fat...
2019/0134067 Topical Minocycline Compositions and Methods of Using the Same
Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent...
2019/0134066 TREATMENT OF MODERATE TO SEVERE INFLUENZA
The invention provides a compound, namely acetylsalicylic acid (ASA) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising...
2019/0134065 COMPOUNDS FOR PRENATAL TREATMENT COMPRISING A NATAL VITAMIN AND ASPIRIN AND METHODS FOR MAKING AND USING THE SAME
Compounds including vitamins and aspirin are disclosed. The compounds are provided in dosage form and preferably include selected amounts of folic acid,...
2019/0134064 SELECTIVELY DEGLYCOSYLATED VITAMIN D-BINDING PROTEIN (GCMAF), CHOLECALCIFEROL (CALCIOL), AND PRODUCTION METHOD
The invention relates to a dimeric complex of a selectively deglycosylated vitamin D-binding protein (GcMAF) and cholecalciferol (calciol). The invention...
2019/0134063 Compositions and Methods for the Treatment of Skin Lesions
Topical compositions for dermal use comprising a TSLP inducing agent, a cytotoxic agent, and an NSAID agent and methods of using them for the treatment of...
2019/0134062 PHARMACEUTICAL COMPOSITIONS AND METHODS
This invention relates the use of cortisol blockers (e.g., glucocorticoid receptor [GR] antagonists) for the treating or preventing viral infections, treating...
2019/0134061 CONTROLLED RELEASE AND TASTE MASKING ORAL PHARMACEUTICAL COMPOSITIONS
The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least...
2019/0134060 25-HYDROXYCHOLESTEROL AND METHODS OF USE THEREOF
The present disclosure provides compositions comprising 25-hydroxycholesterol, derivatives and prodrugs thereof, and methods of use thereof. Specifically,...
2019/0134059 FULVESTRANT FORMULATIONS AND METHODS OF THEIR USE
The disclosure is directed to fulvestrant formulations including suspensions of fulvestrant particles suitable for injection. The formulations can comprise...
2019/0134058 USE OF SUGAR-ALCOHOLS IN TIBOLONE COMPOSITIONS
A method of stabilizing tibolone in a solid dosage form using a sugar-alcohol, and a pharmaceutical composition, in particular a solid dosage form such as a...
2019/0134057 USE OF GABAA RECEPTOR MODULATORS FOR TREATMENT OF ITCH
A compound for use in the treatment of itch is provided, wherein the composed comprises the general formula (1a), general formula (1b) or general formula (1c)....
2019/0134056 K-RAS MUTATIONS AND ANTAGONISTS
The present application relates to K-Ras mutations, to polynucleotides encoding mutant K-Ras polypeptides, and to methods of identifying small molecule...
2019/0134055 Treatment of Addiction and Impulse-control Disorders Using PDE7 Inhibitors
This disclosure is directed to treatment of addictions and primary impulse-control disorders using phosphodiesterase 7 (PDE7) inhibitors, alone or in...
2019/0134054 ASSOCIATION OF ANTAGONISTS OF THE VASOPRESSIN RECEPTOR AND CALCIMIMETICS, COMPOSITION AND USE THEREOF FOR THE...
Combination of antagonists of the vasopressin receptor and calciomimetics and composition comprising it, and its use for the prevention and/or treatment of...
2019/0134053 METHODS AND COMPOSITIONS TO TREAT CANCER
Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.
2019/0134052 DOSAGE REGIMEN FOR A PI-3 KINASE INHIBITOR
The present invention relates to a dosage regimen for a phosphatidylinositol 3-kinase (PI3K) inhibitor compound of formula (I) or a pharmaceutically acceptable...
2019/0134051 COMPOSITION FOR TREATING OCULAR DISORDERS SUCH AS MACULAR DEGENERATION, RETINOPATHY AND GLAUCOMA
An aqueous ophthalmic composition for treating ocular disorders, such as macular degeneration and retinopathy, includes Timolol Maleate at a concentration of...
2019/0134050 DIMERIC COMPOUNDS
The present invention provides a compound of formula I which act as inhibitors of SMAC protein binding to Inhibitor of Apoptosis Proteins (IAPs), and/or...
2019/0134049 COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1/PD-L1 INHIBITOR
The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of...
2019/0134048 Nucleotide Analogs
Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a ...
2019/0134047 A MIXTURE OF D-SERINE AND CAFFEINE FOR OBTAINING THE EFFECT OF PREVENTING THE DECLINE OF LEARNING ABILITY OR...
Provided is a mixture containing D-serine and caffeine as an active ingredient for obtaining the effect of preventing the decline of learning ability or memory...
2019/0134046 HETEROCYCLIC COMPOUNDS AS ANTIBACTERIALS
The present invention relates to the following compounds ##STR00001## wherein the integers are as defined in the description, and where the compounds may be...
2019/0134045 METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS
Described herein are methods for modulating the amount of a gene product and compounds for use in such methods. More particularly, described herein are methods...
2019/0134044 FORMULATIONS OF MILCICLIB AND THERAPEUTIC COMBINATIONS OF THE SAME FOR USE IN THE TREATMENT OF CANCER
This application relates to methods of treating and/or preventing cancer (e.g., non-small cell lung cancer, renal cell carcinoma, hepatocellular carcinoma,...
2019/0134043 New Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD)
The application refers to a novel combination treatment/combination medicament for PF-ILD treatment, comprising as a first combination partner a...
2019/0134042 TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS WITH CCR2 ANTAGONISTS
Provided herein are methods of treating focal segmental glomerulosclerosis, said methods include administering to a subject in need thereof a therapeutically...
2019/0134041 COMBINATION THERAPY COMPRISING AN ACC INHIBITOR
The present disclosure provides methods and compositions for treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver...
2019/0134040 HETEROCYCLYLAMINES AS PI3K INHIBITORS
The present invention provides heterocyclylamine derivatives of Formula I: ##STR00001## wherein the variables are defined herein, that modulate the activity of ...
2019/0134039 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and ...
2019/0134038 SALT OF FUSED HETEROCYCLIC DERIVATIVE AND CRYSTAL THEREOF
The present invention provides 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyl-oxy)-4-methoxyphenyl]-2,4-dio- xo- 1,2,3,4-tetrahydrothieno [3...
2019/0134037 INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN
This invention is directed to the treatment of pain by inhibiting adaptor associated kinase 1 (AAK1). Numerous AAK1 inhibitors are disclosed.
2019/0134036 TOPICAL FORMULATIONS OF PDE-4 INHIBITORS AND THEIR METHODS OF USE
Embodiments herein are directed to topical formulations of a compound represented by the formula (I), salt, metabolite, prodrug, or hydrate thereof along with...
2019/0134035 Quinazoline Compounds
Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and...
2019/0134034 Method of Treating Liver Cancer
A method of treating liver cancer, such as hepatocellular carcinoma, by administering a compound of formula (I), such as Varlitinib, or an enantiomer thereof,...
2019/0134033 PHARMACEUTICAL COMBINATIONS
A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor...
2019/0134032 GLUTAMINASE INHIBITOR THERAPY
Disclosed herein are methods of treating a subject having an altered NRF2/KEAP1 pathway, and compounds and compositions useful in such treatment. Also...
2019/0134031 ANTICANCER AGENTS
Disclosed herein are therapeutic methods of administering compounds that modulate the C--C chemokine receptor type 4 (CCR4) for the treatment of Epstein Bar...
2019/0134030 DIPEPTIDYL PEPTIDASE-4 INHIBITORS FOR TOPICAL EYE TREATMENT OF RETINAL NEURODEGENERATIVE DISEASES
The invention relates to dipeptidyl peptidase-4 inhibitors, including saxagliptin and sitagliptin, for use in the topical eye treatment and/or prevention of...
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