Patents

Searching:





Search by keyword, patent number, inventor, assignee, city or state:




Patent # Description
US-7,968,599 Fast release solid formulation, preparation and use thereof
The present invention relates to a chemically stable formulation of florfenicol, (and structurally related compounds) in compositions such as soluble blended...
US-7,968,598 Ester compound and use thereof
An ester compound represented by the formula (1): ##STR00001## wherein R represents a C1-C4 alkyl group or a C3-C4 alkenyl group, and A represents a single...
US-7,968,597 Levodopa prodrug mesylate, compositions thereof, and uses thereof
(2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical...
US-7,968,596 Preparation and diabetic use of Gibberellins
The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical...
US-7,968,595 Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the...
The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: ...
US-7,968,594 Pharmaceutical compositions for the treatment of pain
The present invention relates to treatment of cancer related pain and constipation. Preferably the subject in need is administered a combination of the...
US-7,968,593 Thiolactones
This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for...
US-7,968,592 3-aminopyrrolidone derivatives
3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in...
US-7,968,591 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments
1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I ##STR00001## methods for their production, pharmaceutical compositions...
US-7,968,590 IAP binding compounds
IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells...
US-7,968,589 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions...
US-7,968,588 Injectable formulation of antibiotic and solution for intravenous administration thereof
A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A.sub.2, as an active ingredient, which is stable and contains...
US-7,968,587 Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a...
US-7,968,586 Cytotoxic compounds and conjugates
The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate...
US-7,968,585 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
The present invention discloses novel compounds of Formula (I): having 11.beta.-HSD type 1 antagonist activity, as well as methods for preparing such compounds....
US-7,968,584 Substituted arylpyrazoles
This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically...
US-7,968,583 Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors
Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their...
US-7,968,582 5(S)-substituted pyrazoline compounds, their preparation and use as medicaments
The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use...
US-7,968,581 Imidazolidine compounds as androgen receptor modulators
Novel compounds are disclosed that have a Formula represented by the following: ##STR00001## wherein X, R.sup.1, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3a...
US-7,968,580 Imidazolidin-2-one derivatives as selective androgen receptor modulators (SARMS)
The present invention is directed to novel imidazolidin-2-one derivatives having a structure according to Formula I ##STR00001## wherein a, b, R.sup.1,...
US-7,968,579 Antifungal triazole derivatives
Disclosed herein are antifungal triazole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical...
US-7,968,578 Indole amide derivatives as EP4 receptor antagonists
The invention is directed to indole amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute...
US-7,968,577 Modulators of glucocorticoid receptor, AP-1, and/or NF-.kappa.B activity and use thereof
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or...
US-7,968,576 Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
US-7,968,575 Nitric oxide donors and uses thereof
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is...
US-7,968,574 Biaryl compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: ...
US-7,968,573 Hydrazide compound and pesticidal use of the same
A hydrazide compound represented by the formula (1): ##STR00001## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A.sup.1, A.sup.2, J, Q and n are defined in the...
US-7,968,572 Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
It is intended to provide a compound represented by the formula (I): ##STR00001## wherein all the symbols are as defined in the description; which has a p38...
US-7,968,571 2,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of...
The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the...
US-7,968,570 Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
The present invention is directed to compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
US-7,968,569 Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are...
US-7,968,568 Substituted piperidine derivatives as SST5 modulators
This invention is concerned with compounds of the formula ##STR00001## wherein A, R.sup.1 to R.sup.5 and G are as defined in the description and claims, and...
US-7,968,567 Compounds for the modulation of PPAR.gamma. activity
Modulators of PPAR.gamma. activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II...
US-7,968,566 Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase...
Novel compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in...
US-7,968,565 Therapeutic combinations comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-ox- ...
The present invention relates to SNS-595 and methods of treating cancer using the same.
US-7,968,564 HIV integrase inhibitors
Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: ##STR00001## wherein bond a, ring A, R.sup.1, R.sup.2 and...
US-7,968,563 Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, ...
US-7,968,562 Pharmaceutical formulations comprising an immune response modifier
Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine...
US-7,968,561 Steroidal compounds as steroid sulphatase inhibitors
There is provided a compound having Formula I ##STR00001## wherein G is a fluorocarbyl group, and wherein R.sup.1 is any one of a sulphamate group, a...
US-7,968,560 Compounds that modulate PPAR.gamma.-type receptors and cosmetic/pharmaceutical compositions comprising said...
Novel compounds having the general formula (I) below: ##STR00001## are useful in a wide variety of applications in human or veterinary medicine (in...
US-7,968,559 Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders: ...
US-7,968,558 Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents
The present invention concerns novel amidines derivatives of 2-heteroaryl-quinazoline and quinolines of general formula (I), to a process for their preparation,...
US-7,968,557 Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent...
US-7,968,556 Heteroaryl compounds, compositions thereof, and methods of treatment therewith
Provided herein are Heteroaryl Compounds having the following structure: ##STR00001## wherein R.sup.1, R.sup.3, R.sup.4, L, X, Y, A and B are as defined...
US-7,968,555 Intermediates in the preparation of entecavir via carbon-silicon oxidation
Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation. ##STR00001##
US-7,968,554 Pyrazolo[3,4-d]pyrimidine derivatives
Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and...
US-7,968,553 Tetrahydro-4H-pyrido[1,2-a] pyrimidines useful as HIV integrase inhibitors
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula A: ##STR00001## are described as inhibitors of HIV integrase and inhibitors of HIV...
US-7,968,552 Oxadiazolidinedione compound
A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is...
US-7,968,551 Chromenoneindoles
Chromenoneindole derivatives of the formula (I), in which R.sup.1, R.sup.2, R.sup.3, R, A and B are as defined in Claim 1, and pharmaceutically usable prodrugs,...
US-7,968,550 Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof....
← Previous | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 | Next →