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Patent # Description
US-7,989,653 Exo- and diastereo-selective syntheses of himbacine analogs
This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the...
US-7,989,652 C-nitroso-derived nitroxyl donors
Active compounds of Formula I are described: ##STR00001## wherein: R.sub.1 and R.sub.2 are each independently C1-C4 alkyl; or R.sub.1 and R.sub.2 together...
US-7,989,651 Epoxysilanes, processes for their manufacture and curable compositions containing same
Epoxysilanes are provided which contain at least one epoxy group, at least one hydrolyzable silyl group and one or more linkages containing a carbonyl group...
US-7,989,650 Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
Metal carbonyls are used to deliver CO to organs to limit post-ischaemic damage. The organ may be extracorporeal, e.g. for use in a transplant, or may be an...
US-7,989,649 Tumor imaging compounds
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties...
US-7,989,648 Esters
The present invention is directed to an ester that can be used to produce compositions that are soft solids, which comprises an specific solid ester combined...
US-7,989,647 Polyols derived from a vegetable oil using an oxidation process
A method for producing a vegetable oil-derived polyol having increased hydroxyl functionality by reacting a vegetable oil with an oxidizing agent in the...
US-7,989,646 Biodiesel process
This invention covers a process for making biodiesel from vegetable oils and animal fat with a simple hetrogeneous catalyst providing high yield and reaction...
US-7,989,645 Process for preparation of citalopram and enantiomers
The present invention provides a process for preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofura- n car-bonitrile comprising...
US-7,989,644 Electroluminescent device
Disclosed are electroluminescent devices that comprise organic layers that contain dibenzofuran compounds. The compounds are suitable components of, for...
US-7,989,643 Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives
The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and...
US-7,989,642 Process for producing powdered compositions containing highly unsaturated fatty acid esters of ascorbic acid...
The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a...
US-7,989,641 Methods of synthesizing N-hydroxysuccinimidyl carbonates
The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the...
US-7,989,640 Sulfonylpyrrolidine modulators of androgen receptor function and method
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the...
US-7,989,639 Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E- ...
Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]p- henyl]-2E-2-propenamide are prepared by various methods.
US-7,989,638 Conjugates of biological substances
Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3'-position, their bioconjugates and their uses are...
US-7,989,637 Triazole-substituted arylamides as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted triazolyl, and R.sup.2,...
US-7,989,636 Process for the preparation of pure anastrozole
A process for the preparation of anastrozole which comprises: a) brominating 3,5-bis(2-cyanoprop-2-yl)toluene (II) in an organic solvent using a brominating...
US-7,989,635 Method for producing purified ammonium salt of fluorinated bis-sulfonylimide
Methods for preparing an ammonium salt and a lithium salt of a fluorinated bis-sulfonylimide by a practical and efficient method with a high yield with a small...
US-7,989,634 Melanocortin receptor agonists
The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of...
US-7,989,633 4-Chromenonyl-1,4-dihydropyridines and their use
The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of...
US-7,989,632 Crystalline forms of solvated ilaprazole
The invention relates to crystalline forms of various solvates of ilaprazole, 2[[(4-methoxy-3-methyl-2-pyridinyl)-methyl]sulfinyl]-5-(1H-pyrrol-1-yl)1H- ...
US-7,989,631 Hydrate forms of AMG706
The anti-angiogenic drug AMG 706 is provided in the mono-phosphate hydrate form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at...
US-7,989,630 Radiotracers for imaging P-glycoprotein function
P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain...
US-7,989,629 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl)...
The present invention relates to a compound of formula (I), or a salt thereof ##STR00001## wherein the naphthalene ring is substituted in the 2, 3, 4, 5, 6, 7...
US-7,989,628 2-aminoquinolines
The present invention is concerned with 2-aminoquinoline derivatives of formula I ##STR00001## wherein Z, R1, and Ar1 are as defined herein, pharmaceutical...
US-7,989,627 Optically active cyclic alcohol compound and method for preparing the same
The present invention relates to a method for preparing an optically active cyclic alcohol compound represented by general formula [I]: ##STR00001## [wherein R...
US-7,989,626 Modulators of cellular adhesion
The present invention provides compounds having formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p,...
US-7,989,625 Thienopyridines
The invention relates to novel thienopyridine derivatives of formula (I), wherein R1, R2, R3, R4 and Y have the meaning cited in claim 1, are HSP90-inhibitors...
US-7,989,624 Aryl spirolactam CGRP receptor antagonists
The present invention is directed to compounds of Formula (I): where variables A.sup.1, A.sup.2, B, J, K, m, n, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c and X are...
US-7,989,623 Process for making n-(diphenylmethyl)piperazines
The compound of formula (8), in racemic or single enantiomeric form, is useful in making N-(diphenylmethyl)-piperazines such as cetirizine and levocetrizine. ...
US-7,989,622 Phosphatidylinositol 3-kinase inhibitors and methods of their use
The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as...
US-7,989,621 Method for producing substituted imidazo[1,2-A]pyrazines of ...
The present invention relates to a method for producing marine ostracod crustacean luciferin or a derivative thereof represented by a general formula (4),...
US-7,989,620 Hydantoin derivatives for the treatment of obstructive airway diseases
The invention provides compounds of formula (I), wherein R.sup.1 and R.sup.2 are as defined in the specification; processes for their preparation;...
US-7,989,619 Nanotextured surfaces
The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an...
US-7,989,618 Linezolid crystalline hydrate form and linezolid salts
Linezolid salts, useful as such and as intermediates in a process for the preparation of novel and known crystalline linezolid forms, in particular known as...
US-7,989,617 Crown ether derivatives
The invention describes crown ether chelators, including crown ethers having the formula: ##STR00001##
US-7,989,616 High-phosphate starch
This invention relates to modified starches having an elevated content of phosphate and an elevated content of amylose.
US-7,989,615 Separation of different isoforms of plasmid DNA using ultrafiltration
The invention is a method for isolating a desired plasmid DNA isoform, typically a supercoiled isoform, which includes the steps of obtaining a quantity of...
US-7,989,614 Isolation of nucleic acid
The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid...
US-7,989,613 Inhibition of metallo-.beta.-lactamase by RNA
Compositions and methods for identifying polyribonucleotides that binds with high affinity to a metallo-.beta.-lactamase. The polyribonucleotides inhibit the...
US-7,989,612 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic,...
US-7,989,611 Expression control sequence
An expression control sequence which controls expression of a target gene linked downstream of the expression control sequence depending on an intracellular...
US-7,989,610 Protein, a gene encoding therefor and a method of using the same
An object of the present invention is to search and identify novel antifungal proteins capable of inhibiting the growth of plant pathogenic microorganisms...
US-7,989,609 Nucleic acid sequences encoding invertase proteins
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants.
US-7,989,608 Immunomodulatory agents and methods of use
An antisense oligonucleotide compound, composition, vaccine and methods for treating a variety of conditions characterized by up-regulation of IL-10 in a...
US-7,989,607 Corn event TC1507 and methods for detection thereof
The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the...
US-7,989,606 Phosphatase inhibitor protein-1 as a regulator of cardiac function
The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (1-1). In particular, the 1-1 mutant forms comprise...
US-7,989,605 Compounds and methods for immunotherapy and diagnosis of tuberculosis
Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one...
US-7,989,604 Dispersin B polynucleotides and methods of producing recombinant DspB polypeptides
Isolated nucleic acid sequences and amino acid sequences for soluble, .beta.-N-acetylglucosaminidase or active fragments or variants thereof which promote...
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