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Patent # Description
US-7,989,503 Smooth muscle peristole inhibitor
An emulsion comprising L-Menthol, a fat or oil and a surfactant wherein oil particles have an average diameter of 100 nm or less inhibits a content reduction...
US-7,989,502 Intranasal delivery of modafinil
Modafinil is selectively delivered to the brain, minimizing delivery to the blood, of a person in need thereof by administering to the person a ...
US-7,989,501 Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde
The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a ...
US-7,989,500 Synthesis, methods of using, and compositions of cycloalkylmethylamines
The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides...
US-7,989,499 Compositions and methods for inhibiting an isoform of human manganese superoxide dismutase
The present invention is directed to methods of modulating the activity of an isoform of manganese superoxide dismutase which is useful for the treatment of...
US-7,989,498 Inhibitors of IMPDH enzyme
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The...
US-7,989,497 Squaramide derivatives as CXCR2 antagonist
The present invention relates to compounds of formula (I) ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, which...
US-7,989,496 Transdermal delivery of ketoprofen polar derivatives
A topical or transdermal composition including a polar derivative of ketoprofen and a pharmaceutically acceptable topical or transdermal carrier, wherein the...
US-7,989,495 Compositions and methods for inhibiting NF-.kappa.B mediated tumorigenicity and adhesion dependent survival of...
Disclosed are compositions and methods for inhibiting NF-.kappa.B mediated cellular proliferation and metastasis.
US-7,989,494 Polymorphs of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E- -2-propenamide
Polymorphic forms of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E- -2-propenamide free base and salts thereof are prepared by...
US-7,989,493 Natural vitamin E compositions with superior antioxidant potency
Compositions for increased antioxidant potency of natural vitamin E(d-alpha-tocopherol), comprising alpha-, beta-, delta-, and gamma-forms of tocopherols and...
US-7,989,492 Epigallocatechin dimers or trimers having lipase inhibitory activity and/or antioxidant activity
An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the...
US-7,989,491 Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating...
US-7,989,490 Injectable formulations of taxanes for cad treatment
Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered for the treatment...
US-7,989,489 Method of treating leukemia with docetaxel and vinca alkaloids
Antitumor combinations comprising a taxane and at least one therapeutically useful substance for treating neoplastic diseases are described.
US-7,989,488 Compositions and methods for storing holographic data
In one aspect, the present invention provides a novel thiophene-containing polynitrone compound having structure (II) ##STR00001## wherein R.sup.1 is...
US-7,989,487 Estrogen receptor modulators and uses thereof
A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount...
US-7,989,486 Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus...
The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV)...
US-7,989,485 Imidazole compounds having pharmaceutical activity towards the sigma receptor
The present invention relates to compounds of formula (I), ##STR00001## methods for their preparation, medicaments comprising these compounds as well their use...
US-7,989,484 Dual-acting antihypertensive agents
The invention relates to compounds having the formula: ##STR00001## wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically...
US-7,989,483 4-heteroarylimidazole-2-thione tyrosinase inhibitors and pharmaceutical/cosmetic applications thereof
Novel 4-heteroarylimidazole-2-thione tyrosinase inhibiting compounds corresponding to the following general formula (I): ##STR00001## formulated into...
US-7,989,482 Indoline anti-cancer agents
Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
US-7,989,481 Indane derivatives as modulators of ion channels
The present invention relates to indane derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions...
US-7,989,480 Aryl amino acid derivatives as inhibitors for treating inflammation
The present invention relates to a chemical genus of 3-(triaryl)-2-aminopropanol derivative inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the...
US-7,989,479 Use of a p38 kinase inhibitor for treating psychiatric disorders
The use of 6-(S-Cyclopropylcarbamoyl-S-fluoro-2-methyl-phenyl)-N-(2,2-dimethylproyl)- -nicotinamide, which is known in the art as a p38 kinase inhibitor in the ...
US-7,989,478 Cinnamoyl compound and use of the same
The present invention relates to a cinnamoyl compound represented by the formula (I): ##STR00001##
US-7,989,477 Monocyclic heterocycles as kinase inhibitors
The present invention is directed to compounds having the formula ##STR00001## and methods for using them for the treatment of cancer.
US-7,989,476 Electron-transporting materials and processes for making the same
Compound of formula C is made by reacting a compound of formula A with an pyridyl boronic acid or pyridyl borate ester to form a compound of formula B; and ...
US-7,989,475 Substituted pyrazoles, compositions containing such compounds and methods of use
The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor...
US-7,989,474 Use of Lck inhibitors for treatment of immunologic diseases
The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors...
US-7,989,473 Stable laquinimod preparations
The invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable salt of ...
US-7,989,472 Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions...
US-7,989,471 Macrocyclic inhibitors of hepatitis C virus
Inhibitors of HCV of formula (I) ##STR00001## and the N-oxides, salts, and stereochemically isomeric forms thereof, wherein the terms R1, L, R2, R3, R4, and...
US-7,989,470 3,8-substituted 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake...
This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention...
US-7,989,469 Certain chemical entities, compositions, and methods
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal...
US-7,989,468 Methods of using SNS-595
The present invention relates to SNS-595 and methods of treating cancer using the same.
US-7,989,467 Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related...
The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases...
US-7,989,466 Methods to inhibit or augment an inflammatory response
Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
US-7,989,465 4,6-disubstituted pyrimidines useful as kinase inhibitors
The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable salts and compositions thereof,...
US-7,989,464 mGluR1 antagonists as therapeutic agents
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J.sup.1-J.sup.4, X, and R.sup.1-R.sup.5 are as defined herein)...
US-7,989,463 Biccyclic compounds as GATA modulators
Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically...
US-7,989,462 4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis...
Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are...
US-7,989,461 Substituted quinazolinamine compounds for the treatment of cancer
The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated...
US-7,989,460 Quinazoline derivatives as angiogenesis inhibitors
The present invention relates to compounds of the formula I: ##STR00001## wherein: ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which...
US-7,989,459 Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC.theta.. inhibitors, and their methods of use are disclosed. The genus is...
US-7,989,458 Pyrimidine derivatives as alk-5 inhibitors
Compounds of formula (I) in free or salt or solvate form, where T.sup.1, T.sup.2, R.sup.a and R.sup.b have the meanings as indicated in the specification, are...
US-7,989,457 Glucagon receptor antagonists, preparation and therapeutic uses
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse...
US-7,989,456 Pyrazine kinase inhibitors
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions...
US-7,989,455 Compounds, compositions and methods
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of...
US-7,989,454 Leukotriene B4 inhibitors
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
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