Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors
The present invention provides an aryl- or heteroaryl compound represented by the formula (Ia) or (Ib) ##STR00001## wherein each symbol is as defined in the...
Binding inhibitor of sphingosine-1-phosphate
The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P.sub.1) and which are...
There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF.sub.1) receptor antagonists.
Bicyclic nitrogen-containing heterocyclic compounds
A nitrogen-containing bicyclic heterocyclic compound represented by the following formula (1) is provided. When the compound or a salt thereof is administered...
Anthranilamide compounds, process for their production and pesticides
Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to...
Cycloalkane-substituted pyrazoline derivatives, their preparation and use
The present invention relates to Cycloalkane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising...
Heterocyclic compounds, methods for the preparation thereof, and uses
The compounds of the present invention are of formula I: ##STR00001## wherein A, R.sup.3, R.sup.4 is as defined herein, are useful as ligands for nicotinic...
Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
Compounds of formula (I); wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase. ##STR00001##
Method of therapeutic administration of DHE to enable rapid relief of
migraine while minimizing side effect profile
Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side...
Indazole compound and pharmaceutical use thereof
The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole...
Therapeutic substituted piperidone compounds
Compounds comprising ##STR00001## or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions,...
This invention relates to novel compounds that are 4-oxoquinoline derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention...
Selective serotonin 2A/2C receptor inverse agonists as therapeutics for
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in...
Substituted thienopyridone compounds with antibacterial activity
Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally...
Heterocyclic cyclopamine analogs and methods of use thereof
The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
Modulators of glucocorticoid receptor, AP-1, and/or NF-.kappa.B activity
and use thereof
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1 and/or...
The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is...
Compounds for treating inflammatory diseases
The invention relates to the use of (1.alpha..2.beta.,4.beta..5.alpha..7.beta.)-7-[(hydroxydi-2-thienylacetyl- ...
HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones
HIV inhibitory compounds of formula: ##STR00001## salts, hydrates, solvates, N-oxides, or stereoisomers thereof, wherein A forms pyridine, pyrimidine,...
Pharmaceutical compositions containing camptothecins
A camptothecin-containing pharmaceutical composition which contains: (a) camptothecin or a derivative thereof, and (b) one or more compounds selected from among...
Benzene sulfonamide thiazole and oxazole compounds
The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the...
Small molecules that replace or agonize p53 function
This invention provides a novel screening system for identifying p53 mimetics/agonists. Also provided are small organic molecules that act as effective p53...
Solid preparation comprising
The present invention provides a solid preparation containing 2[[6-[(3R)-3-amino-1 -piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-- ...
Quinazolinone-derivatives and their use for preparation of pharmaceutical
compositions having PARP enzyme...
The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a...
6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics
and anti-inflammatory agents
The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates...
Processes for preparing intermediates of pemetrexed
The invention provides intermediates of pemetrexed of formula VI and processes for the preparation thereof. ##STR00001##
Carbamoyl compounds as DGAT1 inhibitors 190
DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions,...
Crystalline rosuvastatin calcium and compositions thereof for treatment of
The present invention provides a crystalline form of rosuvastatin calcium characterized by an X-ray powder diffraction pattern having peaks at about 4.7, 19.4...
Therapeutic agents useful for treating pain
The present invention discloses a compound of formula: ##STR00001## where Ar.sub.1, Ar.sub.2, X, Z.sub.1, Z.sub.2, R.sub.3, and m are as disclosed herein or a...
Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
The present invention discloses novel compounds of Formula I: having 11 Beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In...
Cosmetic use of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides
and related compounds
Cosmetic compositions comprising 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and methods of using such compositions to impart anti-aging benefits...
Pyridyl sulfonamides as modulators of ion channels
The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable...
The present invention is concerned with novel compounds of formula (I) having fundic relaxating activity. The invention further relates to methods for preparing...
[1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as
serine-theoronine kinase modulators...
The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and...
Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors
The invention relates to novel organic compounds of formula (I) ##STR00001## processes for the preparation thereof, the application thereof in a process for...
3,4-diaminopyridine derivatives for use as catalysts
The present invention relates to 3,4-diaminopyridine derivatives of formula (I) ##STR00001## wherein R.sup.1 and R.sup.2 are, independently of each other,...
Hexahydro-pyrazino[1,2-A]pyrimidine-4,7-dione derivatives substituted with
The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated...
Pentafluorosulphanyl-substituted compound and its use for producing
The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of...
Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels
for the treatment of pain
The present invention relates to pyrrolidinone benzenesulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically...
Aryl aniline derivatives as .beta..sub.2 adrenergic receptor agonists
The invention provides novel .beta..sub.2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such...
Mineralocorticoid receptor antagonists and methods of use
The present invention provides a compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a...
6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT.sub.2C
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of...
2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use
thereof, and compositions containing...
The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzodiazepine compounds, to pharmaceutical compositions comprising such compounds, to...
Derivatives of 2-alkoxy-3,4,5-trihydroxy-alkyl amides, preparation and use
thereof, and compositions containing...
The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide derivatives, to pharmaceutical compositions comprising such compounds, to methods of...
Pyridazine compounds as glycogen synthase kinase 3 inhibitors
Disclosed are pyridazine compounds of the formula I which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds,...
c-Kit kinase inhibitor
It was discovered that a compound represented by the general formula (I) shows strong c-Kit kinase inhibitory activity, and it inhibits proliferation of c-Kit...
Method for inhibiting tumor growth with dehydrosulphurenic acid extracted
from Antrodia cinnamomea
The present invention relates to a method for inhibiting tumor growth, in particular to the method using dehydrosulphurenic acid to inhibit the growth of...
Method for dispersing plant sterol for beverage and a plant
sterol-dispersed beverage, of which particle size...
Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed...
Carboxylic acid 4-phenylazo-phenyl ester derivatives and their use as
monoamine neurotransmitter re-uptake...
This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects...