Growth stimulant compositions
An improved weight and growth stimulant for domesticated animals such as cattle, pigs and sheep is comprised of an anabolic agent that is subcutaneously...
Compounds having estrogenic activity
The present invention provides compounds having estrogenic activity selected from the group consisting of RRR-.alpha.-tocopherol, hydro-Q.sub.9 chromene,...
Antioxidant compositions and methods thereto
The present invention provides a performance assay that measures the total antioxidant activity of a composition using oxygen uptake in contrast to prior art...
Use of N-(dibenz(b,f)oxepin-10-ylmethyl)-N-methyl-N-prop-2-ynylamine
(omigapil) or a pharmaceutically...
The invention relates to the use of a compound of the formula (I) ##STR00001## or a pharmaceutically acceptable addition salt thereof for the preparation of a...
Antiviral compounds and methods of using thereof
Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae,...
The present invention is directed to the compounds of formula ##STR00001## wherein R.sup.1 to R.sup.4 have the significances given herein, to processes for the...
Cyclohexyl substituted pyrrolidinones as inhibitors of
11-beta-hydroxysteroid dehydrogenase 1
The present invention discloses novel compounds of Formula I: having 11.beta.-HSD type 1 antagonist activity, as well as methods for preparing such compounds....
Therapeutic substituted lactams
Disclosed herein are compounds having a formula: (I) Compositions, methods, and medicaments related thereto are also disclosed. ##STR00001##
Inhibitors of fibroblast activation protein alpha
Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein...
Substituted pyrazoline compounds for reducing triglycerides in blood
The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use...
LXR and FXR modulators
Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are...
Solid forms of
and methods of...
Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising ...
Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.4, and W are defined in the description are TRPV 1 antagonists with CNS penetration....
Oxazolidinone derivative having inhibitory activity on
11.beta.-hydroxysteroid dehydrogenase type 1
Disclosed is a compound which is useful as an 11.beta.-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: ##STR00001## its...
Neurotherapeutic treatment for sexual dysfunction
A method for improving sexual function is described. A mammal suffering from sexual dysfunction or otherwise in need of enhanced sexual function is administered...
5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors
The present invention concerns a compound of formula Ia wherein: R.sup.a* is hydrogen or C.sub.1-C.sub.4-alkyl; R.sup.b* is ...
2-Imino-1,3-thiazoline-based compounds and T-type calcium channel
inhibitors containing the same
Novel 2-imino-1,3-thiazoline based compounds represented by Chemical Formula I, and T-type calcium channel inhibitors containing the compound are provided. The...
Biphenyl compounds useful in the treatment or prevention of cardiovascular
The invention relates to biphenyl compounds of formula (I): ##STR00001## wherein U, V and W together form a group of the formula *--CH.dbd.CH--CH<,...
Inhibitors of c-Met and uses thereof
The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions...
Modulators of LXR
Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for...
1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor
Compound and pharmaceutical compositions comprising the compounds of the Formula ##STR00001## or a pharmaceutically acceptable salt thereof, as a CB.sub.1...
2-pyridone derivatives for the treatment of disease or condition in which
inhibition of neutrophil elastase...
The invention provides compounds of formula ##STR00001## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.14, X and W are as defined in the...
Substituted isoxazoles as fungicides
The present invention provides compounds of formula I: ##STR00001## along with methods of making the same, compositions thereof, and methods of use thereof,...
Amide derivatives as TRPV1 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, ...
Aminoaryl sulphonamide derivatives as functional 5-HT.sub.6 ligands
The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the...
Compounds for modulating TRPV3 function
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Antibacterial quinoline derivatives
The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): ##STR00001## including any...
Substituted 2-amino-fused heterocyclic compounds
The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.1, R.sup.2, Z.sup.1, t, and...
Inhibitors of AKT (protein kinase B)
4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt...
Certain chemical entities, compositions and methods
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal...
Nitrogenous fused-ring derivatives, medicinal compositions containing the
derivatives, and use thereof as drugs
The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts...
Fused heterocyclic compounds and their use as sirtuin modulators
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a...
Tivozanib and temsirolimus in combination
A method of treating a tumor in a human patient is disclosed. The method comprises co-administering to the patient: (a) a dose of 1.5 mg tivozanib per day; and...
1H-imidazo[4,5-c]quinoline derivatives in the treatment of protein kinase
The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of...
Combinations containing a 4-acylaminopyridine derivative
The instant disclosure describes compositions and methods for treating diseases and conditions of the central and peripheral nervous system. The disclosure...
Use of finasteride, dutasteride and related compounds for the prevention
or treatment of...
The present invention relates to new pharmaceutical uses of 4-azasteroid compounds, in particular of Finasteride/Dutasteride/Dutasteride and Dutasteride,...
Non-nucleoside reverse transcriptase inhibitors
The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the...
Substituted pyrimidines and [1,2, 4] triazoles and the use thereof for
treating prophylaxis, cardiovascular...
A compound represented by the formula (I): ##STR00001## wherein R1 is an oxo group, .dbd.N--R or the like; a group represented by the formula: ##STR00002## ...
Methotrexate adjuvants to reduce toxicity and methods for using the same
Methods are provided for using methotrexate (MTX) in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an...
Axl kinase inhibitors
Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by...
Glutamate aggrecanase inhibitors
The present invention relates to modulators of metalloproteinase activity.
N-hydroxyamide derivatives and use thereof
The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune...
Arylpiperazine derivatives and uses thereof
Compounds of formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein Ar is indolyl, indazolyl or dihydroindolyl, and R.sup.1, R.sup.2,...
Enantiomers of 2'-Fluoralky1-6-nitroquipazine as serotonin transporter
positron emission tomography imaging...
Racemic mixtures and individual enantiomers of fluorine-18 or carbon-11 radiolabelled 2'-alkyl-6-nitroquipazine ligands are serotonin transporter (SERT) tracers...
Hydantoin derivatives useful as antibacterial agents
This invention relates to compounds of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful...
Affinity adsorbents for plasminogen
For the separation, removal, isolation, purification, characterization, identification or quantification of plasminogen or a protein that is a plasminogen...
Modulators of 11-.beta. hydroxyl steroid dehydrogenase type 1,
pharmaceutical compositions thereof, and methods...
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the...
Substituted N-arylsulfonylheterocyclic amines as gamma-secretase
Disclosed are novel gamma secretase inhibitors of the formula: ##STR00001## Also disclosed are methods for inhibiting gamma secretase, for treating one or more...
Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use
This invention provides compounds having the structure ##STR00001## which may be used for the treatment of tumors.
Benzoxazines and related nitrogen-containing heterobicyclic compounds
useful as mineralocorticoid receptor...
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: ##STR00001## wherein Ring...