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The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) ##STR00001## [wherein n represents 1 or 2, Z represents a...
Use of inhibitors of the renin-angiotensin system
It has been found that inhibitors of the rennin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia or impaired...
Thiolactams and uses thereof
This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as described in the...
HCV NS5B inhibitors
The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C...
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
Bicyclic heterocycles, drugs containing said compounds, use thereof, and
method for production thereof
The present invention relates to bicyclic heterocycles of general formula ##STR00001## wherein R.sup.a, R.sup.b and R.sup.c are defined as in claim 1, their...
Pharmaceutical composition for treating esophageal cancer
A method of treating esophageal cancer, containing the step of administering to a patient suffering from esophageal cancer, a compound or a salt thereof,...
Materials and methods for treatment of cancer and identification of
The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the...
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the...
Methods for the treatment and amelioration of atopic dermatitis
The present invention relates to a method for the treatment and/or amelioration of atopic dermatitis, the method including the administration of a...
Polymerizable compound and use thereof
The present invention is to provide a polymerizable compound which can be a raw material for a resin having high transparency, good heat resistance and...
Core 2 GlcNAc-T inhibitors III
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising...
Eye drop preparation comprising xanthan gum and terpenoid
The present invention provides an ophthalmic solution containing xanthan gum and terpenoid, which shows a suppressed decrease in the terpenoid content, by the...
Hypoxia inducible VEGF plasmid for ischemic disease
Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF)...
Aptamers to von Willebrand factor and their use as thrombotic disease
The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as...
Aptamers that bind thrombin with high affinity
The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases...
Cancer treatment by combined inhibition of proteasome and telomerase
A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor....
Flavonoid compound having an antiviral activity
The present invention relates to a flavonoid compound having an antiviral activity, more particularly to a flavonoid compound obtained by extracting Houttuynia...
Use of timosaponin Bll in the preparation of a medicament or product for
the prevention and treatment of stroke
The invention disclosed the use of timosaponin BII in the preparation of a medicament or product for the prevention and treatment of stroke. The experiments...
Quinaldine based semisquaraines and squaraine dyes, process for
preparation thereof and use thereof
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3...
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2...
Process for treating the skin comprising applying to the skin at least one
composition comprising at least one...
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use...
Inhibition of angiogenesis by neutrophil alpha-defensins
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the...
Vascular endothelial cell growth factor antagonists and uses thereof
The present invention provides vascular endothelial cell growth factor (VEGF) antagonists and methods of using VEGF antagonists. VEGF antagonists contemplated...
Modified growth hormones
Provided are modified growth hormone polypeptides, nucleic acid molecules encoding modified growth hormone polypeptides and methods of generating modified...
Solution preparations stabilized over long time
A G-CSF solution formulation which is substantially free from proteins as a stabilizer but which contains at least one amino acid or a salt thereof as a...
Method of treatment of type-1 diabetes with a humanin analogue
The present invention is based on the discovery that Humanin and humanin analogues protect pancreatic beta cells in vitro and in vivo from apoptosis....
Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,...
Dimerized T-cell receptor fragment, its compositions and use
Dimers of a peptide from the T-cell receptor (Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr) (SEQ ID NO:1) are disclosed for preventing the...
Spatially-defined modification of fresh tissue using covalent chemistry
Methods for modification of tissue using covalent chemistry. Tissue can be modified through direct alkylation, reduction followed by alkylation, or oxidation...
Compounds that bind to p185 and methods of using the same
Novel peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic...
Bioactivation of particles
Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one...
Process for treating fibroses with biocompatible polymer
A biocompatible polymer constituted by a sequence of identical or different components of the general formula (I): A.sub.aX.sub.xY.sub.y, in which A represents...
Method of reducing toilet odor
A method of eliminating or at least reducing toilet odor by applying a liquid composition directly to the water contained in a toilet bowl prior to use. The...
Sulfonated estolide compositions containing magnesium sulfate and
processes employing them
Formulations of sulfo-estolides, sulfo-estolide derivatives and salts of sulfo-estolides that contain magnesium ions are described. Methods of manufacture and...
Compositions for treating hard surfaces comprising silyl polyalkoxylates
The invention relates to compositions for treating a hard surface, in particular for cleaning and/or dirt-repellent treatment of a hard surface, containing a)...
Cleaning compositions for hard surfaces comprising a silyl polyalkoxylate
Aqueous liquid compositions containing: (a) at least one alkyl ether sulphate (b) at least one multi-armed silyl polyalkoxylate of the formula (I)...
Visually enhancing heavy duty degreaser-cleaning composition
A visually enhancing degreaser/cleaning composition for removing grease stains adhering to metallic surfaces in the kitchen. The cleaning composition in powder...
Replacement solvents having improved properties and methods of using the
CFC replacement solvent compositions, methods of using the same and methods of making the same. These compositions meet or exceed the solvency, flammability,...
Benefit compositions comprising polyglycerol esters
The instant disclosure relates to compositions comprising selected polyglycerol esters and a treatment and/or care agent. The disclosed compositions may be...
Cleaning solution for semiconductor device or display device, and cleaning
A cleaning solution for semiconductor devices or display devices containing a polyamine of a specified structure having two or more amino groups in adjacent...
Flow modifiers for improved magnetic recording device
Additives that inhibit the passage of oil across oil-air interfaces in disk drives and enable the use of the lower viscosity oil in disk drives are disclosed....
Composite lubricant for hard disk media
A composite lubricant for recording disk media, a recording disk media including a layer of the composite lubricant, and method of manufacturing the same are...
Environmental friendly fracturing and stimulation composition and method
of using the same
A non-toxic, environmentally friendly, green flowback aid is disclosed that reduces water blockage when injected into a fractured reservoir. The composition...
Treatment fluids comprising relative permeability modifiers and methods of
Treatment fluids for and methods of treating subterranean formations are provided. In certain embodiments, a method is provided comprising providing a treatment...
Foaming agent for subterranean formations treatment, and methods of use
A wellbore treatment fluid is formed from an aqueous medium, a gas component, a viscosifying agent, and a surfactant. The surfactant is represented by the...
Fluid loss control and well cleanup methods
A method for removing preexisting filtercake from a portion of a subterranean formation penetrated by a wellbore is carried out by providing water-degradable...
Porous particulate materials and compositions thereof
Methods and compositions useful for subterranean formation treatments, such as hydraulic fracturing treatments and sand control that include porous materials....
Methods and compositions for treating subterranean formations
Methods and compositions useful in treating subterranean formations, and more particularly, breaker compositions that may be useful in treating subterranean...
Drilling fluid containing chlorosulfonated alpha-olefin copolymers
This invention is based upon the finding that certain chlorosulfonated .alpha.-olefin copolymers can be beneficially utilized in drilling fluids that are...