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Patent # Description
US-8,008,293 Bicyclic oxomorpholine derivative
The present invention relates to a compound represented by formula (I): ##STR00001## wherein R.sup.1 represents a C1-3 alkyl group, R.sup.2 represents a...
US-8,008,292 Condensed benzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the...
US-8,008,291 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds...
US-8,008,290 Compounds
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, ##STR00001##...
US-8,008,289 .alpha.-aminocyclolactam ligands for G-protein coupled receptors
The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors...
US-8,008,288 Anti-inflammatory A-aminocyclolactam compounds
The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation...
US-8,008,287 Integrase inhibitors
Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
US-8,008,286 Method for treatment of neuropathic pain
Compounds and methods useful for preventing and treating pain, e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be "S1P...
US-8,008,285 Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia
The present invention provides methods of treating fibromyalgia or other diseases or conditions causing widespread pain and/or fatigue. In particular, the...
US-8,008,284 Methods for treatment of cardiovascular disorders and diseases
Propargylamine, propargylamine derivatives including N-propargyl-1-aminoindan, enantiomers and analogs thereof, and pharmaceutically acceptable salts thereof,...
US-8,008,283 Methods and compositions for the treatment of neuropsychiatric disorders
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are...
US-8,008,282 Lipoxin analogs as novel inhibitors of angiogenesis
The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective...
US-8,008,281 Methods for the treatment of cancer
Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed.
US-8,008,280 Betulinol derivatives as anti-HIV agents
The present invention relates to methods of treating HIV-1 infection in a subject. These methods involve administering to the subject with HIV-1 infection a...
US-8,008,279 Compound--827
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible...
US-8,008,278 Diarylmethyl and related compounds
This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Ar.sup.1, Ar.sup.2, E,...
US-8,008,276 Use of zwitterionic polysaccharides for the specific modulation of immune processes
The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design,...
US-8,008,275 Fucose containing proteoglycan or acidic glycan and their pharmaceutical use
A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate...
US-8,008,274 P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-)tetraphosphate, tetra-(alkali metal) salt, for treating sinusitis
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising...
US-8,008,273 SHIP-deficiency to increase megakaryocyte progenitor production
The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing...
US-8,008,272 Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon
Disclosed is a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and...
US-8,008,271 Methods and compositions for treating gain-of-function disorders using RNA interference
The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the...
US-8,008,270 Antiviral oligonucleotides targeting viral families
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are...
US-8,008,269 Antiviral oligonucleotides
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are...
US-8,008,268 Vaccines against vesicular stomatitis
The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis...
US-8,008,267 Stabilized immunomodulatory oligonucleotides
The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5'- or 3'-end. These...
US-8,008,266 Methods of treating cancer using immunostimulatory oligonucleotides
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation,...
US-8,008,265 Vaccines, immunotherapeutics and methods for using the same
Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination...
US-8,008,264 1'-substituted carba-nucleoside analogs for antiviral treatment
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl...
US-8,008,263 Organic compounds and their uses
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
US-8,008,262 .beta.-peptides
.beta.-peptide regions of polypeptides can serve as structural mimics of .alpha.-helices in wild type proteins. Because .alpha.-helices of one protein often...
US-8,008,261 Methods of reducing trail-induced apoptosis by trail isoforms
This document provides to methods and materials related to apoptosis. For example, methods and materials for modulating apoptosis are provided. In addition,...
US-8,008,260 Methods of protecting against apoptosis using lipopeptides
The use of lipopeptides as inducers of NF-.kappa.B for the protection of mammals from the effects of apoptosis is described.
US-8,008,259 Neurotrophin-derived peptide sequences
The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated...
US-8,008,258 Cop 1 for treatment of inflammatory bowel diseases
The present invention relates to the use of Copolymer 1 (glatiramer acetate), a Copolymer 1-related polypeptide, or a Copolymer 1-related peptide, for the...
US-8,008,257 ANF fusion proteins
A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is...
US-8,008,256 Combination therapy for treatment of cancer
The invention relates to compositions and methods for treating diseases. In particular aspects, the invention relates to administering a combination of a...
US-8,008,255 Methods and compositions for enhanced transmucosal delivery of peptides and proteins
Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides...
US-8,008,254 Methods and compositions for the repair and/or regeneration of damaged myocardium
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of cytokines are disclosed and claimed.
US-8,008,253 Treatment for anxiety
The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective...
US-8,008,252 Factor VII: remodeling and glycoconjugation of Factor VII
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a...
US-8,008,251 Macrocyclic inhibitors of hepatitis C virus
Inhibitors of HCV of formula (I). ##STR00001## and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond...
US-8,008,250 Macrocyclic compounds and compositions useful as BACE inhibitors
Macrocyclic compounds of the formula in which R.sub.1, R.sub.3, V.sub.1, V.sub.2, X.sub.1, X.sub.2, Y, Z, Ar, AA and n are as defined in the specification, the...
US-8,008,249 Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as...
Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when...
US-8,008,248 Modified Cry3A toxins and nucleic acid sequences coding therefor
Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease...
US-8,008,247 Tumble dryer bleach and fabric treatment
The invention relates to a treatment article and a method for treating a fabric by delivering one or more powdered benefit agents to a fabric in a tumble dryer...
US-8,008,246 Use of isosorbide ethers in detergents and cleaners
The application pertains to the use of isosorbide ethers according to general formula (I) ##STR00001## wherein R' and R'' independently from each other...
US-8,008,245 Fabric care compositions and systems comprising organosilicone microemulsions and methods employing same
Systems, compositions and methods for fabric laundering comprising selected organosilicones which are formulated into microemulsions for improved deposition...
US-8,008,244 Compositions of tetrafluoropropene and hydrocarbons
Provided are azeotrope-like compositions comprising tetrafluoropropene and one or more selected hydrorocarbons and uses thereof, including use in refrigerant...
US-8,008,243 Azeotrope-like compositions of 1,1,2,3-tetrachloropropene and hydrogen fluoride
An azeotrope-like composition consisting essentially of 1,1,2,3-tetrachloropropene and hydrogen fluoride is provided, as well as methods that involve such an...
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