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| Patent # | Description |
|---|---|
| US-8,008,293 |
Bicyclic oxomorpholine derivative The present invention relates to a compound represented by formula (I): ##STR00001## wherein R.sup.1 represents a C1-3 alkyl group, R.sup.2 represents a... |
| US-8,008,292 |
Condensed benzamide compounds and inhibitors of vanilloid receptor subtype
1 (VR1) activity To provide a compound having an excellent inhibitory effect on vanilloid receptor subtype 1 (VR1) activity which is effective in treating diseases to which the... |
| US-8,008,291 |
3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds... |
| US-8,008,290 |
Compounds A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, ##STR00001##... |
| US-8,008,289 |
.alpha.-aminocyclolactam ligands for G-protein coupled receptors The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors... |
| US-8,008,288 |
Anti-inflammatory A-aminocyclolactam compounds The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation... |
| US-8,008,287 |
Integrase inhibitors Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. |
| US-8,008,286 |
Method for treatment of neuropathic pain Compounds and methods useful for preventing and treating pain, e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be "S1P... |
| US-8,008,285 |
Droxidopa and pharmaceutical composition thereof for the treatment of
fibromyalgia The present invention provides methods of treating fibromyalgia or other diseases or conditions causing widespread pain and/or fatigue. In particular, the... |
| US-8,008,284 |
Methods for treatment of cardiovascular disorders and diseases Propargylamine, propargylamine derivatives including N-propargyl-1-aminoindan, enantiomers and analogs thereof, and pharmaceutically acceptable salts thereof,... |
| US-8,008,283 |
Methods and compositions for the treatment of neuropsychiatric disorders The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are... |
| US-8,008,282 |
Lipoxin analogs as novel inhibitors of angiogenesis The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective... |
| US-8,008,281 |
Methods for the treatment of cancer Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed. |
| US-8,008,280 |
Betulinol derivatives as anti-HIV agents The present invention relates to methods of treating HIV-1 infection in a subject. These methods involve administering to the subject with HIV-1 infection a... |
| US-8,008,279 |
Compound--827 The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible... |
| US-8,008,278 |
Diarylmethyl and related compounds This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Ar.sup.1, Ar.sup.2, E,... |
| US-8,008,276 |
Use of zwitterionic polysaccharides for the specific modulation of immune
processes The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design,... |
| US-8,008,275 |
Fucose containing proteoglycan or acidic glycan and their pharmaceutical
use A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate... |
| US-8,008,274 |
P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-)tetraphosphate, tetra-(alkali
metal) salt, for treating sinusitis The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising... |
| US-8,008,273 |
SHIP-deficiency to increase megakaryocyte progenitor production The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing... |
| US-8,008,272 |
Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus
replicon Disclosed is a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and... |
| US-8,008,271 |
Methods and compositions for treating gain-of-function disorders using RNA
interference The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the... |
| US-8,008,270 |
Antiviral oligonucleotides targeting viral families Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are... |
| US-8,008,269 |
Antiviral oligonucleotides Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are... |
| US-8,008,268 |
Vaccines against vesicular stomatitis The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against vesicular stomatitis... |
| US-8,008,267 |
Stabilized immunomodulatory oligonucleotides The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5'- or 3'-end. These... |
| US-8,008,266 |
Methods of treating cancer using immunostimulatory oligonucleotides Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation,... |
| US-8,008,265 |
Vaccines, immunotherapeutics and methods for using the same Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination... |
| US-8,008,264 |
1'-substituted carba-nucleoside analogs for antiviral treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl... |
| US-8,008,263 |
Organic compounds and their uses The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. |
| US-8,008,262 |
.beta.-peptides .beta.-peptide regions of polypeptides can serve as structural mimics of .alpha.-helices in wild type proteins. Because .alpha.-helices of one protein often... |
| US-8,008,261 |
Methods of reducing trail-induced apoptosis by trail isoforms This document provides to methods and materials related to apoptosis. For example, methods and materials for modulating apoptosis are provided. In addition,... |
| US-8,008,260 |
Methods of protecting against apoptosis using lipopeptides The use of lipopeptides as inducers of NF-.kappa.B for the protection of mammals from the effects of apoptosis is described. |
| US-8,008,259 |
Neurotrophin-derived peptide sequences The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated... |
| US-8,008,258 |
Cop 1 for treatment of inflammatory bowel diseases The present invention relates to the use of Copolymer 1 (glatiramer acetate), a Copolymer 1-related polypeptide, or a Copolymer 1-related peptide, for the... |
| US-8,008,257 |
ANF fusion proteins A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is... |
| US-8,008,256 |
Combination therapy for treatment of cancer The invention relates to compositions and methods for treating diseases. In particular aspects, the invention relates to administering a combination of a... |
| US-8,008,255 |
Methods and compositions for enhanced transmucosal delivery of peptides
and proteins Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides... |
| US-8,008,254 |
Methods and compositions for the repair and/or regeneration of damaged
myocardium Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of cytokines are disclosed and claimed. |
| US-8,008,253 |
Treatment for anxiety The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective... |
| US-8,008,252 |
Factor VII: remodeling and glycoconjugation of Factor VII The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a... |
| US-8,008,251 |
Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV of formula (I). ##STR00001## and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond... |
| US-8,008,250 |
Macrocyclic compounds and compositions useful as BACE inhibitors Macrocyclic compounds of the formula in which R.sub.1, R.sub.3, V.sub.1, V.sub.2, X.sub.1, X.sub.2, Y, Z, Ar, AA and n are as defined in the specification, the... |
| US-8,008,249 |
Neuregulins for prevention and treatment of damage from acute assault on
vascular and neuronal tissue and as... Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when... |
| US-8,008,248 |
Modified Cry3A toxins and nucleic acid sequences coding therefor Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease... |
| US-8,008,247 |
Tumble dryer bleach and fabric treatment The invention relates to a treatment article and a method for treating a fabric by delivering one or more powdered benefit agents to a fabric in a tumble dryer... |
| US-8,008,246 |
Use of isosorbide ethers in detergents and cleaners The application pertains to the use of isosorbide ethers according to general formula (I) ##STR00001## wherein R' and R'' independently from each other... |
| US-8,008,245 |
Fabric care compositions and systems comprising organosilicone
microemulsions and methods employing same Systems, compositions and methods for fabric laundering comprising selected organosilicones which are formulated into microemulsions for improved deposition... |
| US-8,008,244 |
Compositions of tetrafluoropropene and hydrocarbons Provided are azeotrope-like compositions comprising tetrafluoropropene and one or more selected hydrorocarbons and uses thereof, including use in refrigerant... |
| US-8,008,243 |
Azeotrope-like compositions of 1,1,2,3-tetrachloropropene and hydrogen
fluoride An azeotrope-like composition consisting essentially of 1,1,2,3-tetrachloropropene and hydrogen fluoride is provided, as well as methods that involve such an... |
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