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Patent # Description
US-8,013,153 Substituted pyrimidine kinase inhibitors
The present invention is directed to substituted pyrimidine compounds of formula (I): ##STR00001## and forms thereof, their synthesis and use for treating a...
US-8,013,152 Biphenyl compounds useful as muscarinic receptor antagonists
The invention provides compounds of formula I: ##STR00001## wherein a, b, c, m, s, t, W, Z, Ar, R.sup.1, R.sup.2, R.sup.3, R.sup.6, and R.sup.7 are as defined...
US-8,013,151 Process for the preparation of galanthamine hydrobromide
A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of...
US-8,013,150 Process for the preparation of ezetimibe
The present invention relates to a cost effective and industrially advantageous process for the preparation of ...
US-8,013,149 Methods and intermediates for the synthesis of porphyrins
A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: ##STR00001## with (ii) a dipyrromethaneto...
US-8,013,148 Molded object comprising .alpha.-1,4-glucans and/or modifications thereof and process for producing the same
The present application discloses a molded article, and a process for preparing a molded article consisting essentially of (i) high molecular weight linear...
US-8,013,147 Heterocyclic compounds and their use in the detection of nucleic acids
The invention concerns compounds of the general formula (I) in which the residues R.sub.1 to R.sub.7 have the meanings given in the application as well as...
US-8,013,146 RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short...
This invention relates to compounds, compositions, and methods useful for modulating matrix metalloproteinase (e.g., MMP13) gene expression using short...
US-8,013,145 SiRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize...
US-8,013,144 hnRNP K expression-inhibiting compound and siRNA sequence thereof
The present invention discloses an hnRNP K expression-inhibiting compound and a siRNA sequence thereof, wherein a siRNA sequence partially or completely...
US-8,013,143 RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)
This invention relates to compounds, compositions, and methods useful for modulating chemokine receptor (CXCR) gene expression using short interfering nucleic...
US-8,013,142 Compositions for use in identification of bacteria
The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition...
US-8,013,141 Promoter with high expression strength and over-expression in various tissues of plant, as well as application...
The invention provides a promoter that has high expression strength and can be over-expressed in various tissues of plant, said promoter is a promoter for...
US-8,013,140 Promoter for introducing a gene into a lymphocyte or blood cell and application thereof
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In...
US-8,013,139 Promoter for introducing a gene into a lymphocyte or blood cell and application thereof
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In...
US-8,013,138 Chimeric promoters capable of mediating gene expression in plants upon pathogen infection and uses thereof
Described are synthetic promoters capable of mediating gene expression in plants upon pathogen infection. Furthermore, recombinant genes and vectors comprising...
US-8,013,137 Modified enteropeptidase protein
Disclosed are novel enteropeptidase polypeptides, polynucleotides encoding the polypeptides, nucleotide constructs, vectors, host cells comprising the...
US-8,013,136 Oligonucleotides comprising a non-phosphate backbone linkage
One aspect of the present invention relates to a ribonucleoside substituted with a phosphonamidite group at the 3'-position. In certain embodiments, the...
US-8,013,135 Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific...
US-8,013,134 Kit for proximity probing with multivalent proximity probes
The present invention relates to sensitive, rapid and convenient assays for detection and or quantification of one or more analyte(s) in solution using...
US-8,013,133 Genetic modification of targeted regions of the cardiac conduction system
Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the...
US-8,013,132 Synthetic compounds useful as nodulation agents of leguminous plants and preparation processes thereof
The present invention relates to synthetic compounds that are active on plants, especially as legume nodulation factors, and also as plant growth stimulators,...
US-8,013,131 Synthetic membrane anchors
The invention relates to synthetic molecules that spontaneously and stably incorporate into lipid by-layers, including cell membranes. Particularly, although...
US-8,013,130 Carbon-based solid acid, catalyst comprising the solid acid, and reaction using the solid acid as catalyst
A carbon-based solid acid which has high activity and high thermal stability and is useful as an acid catalyst for various reactions such as hydration of...
US-8,013,129 Protein separation device
The invention provides a protein separation device comprising a chaperone protein immobilized on a substrate. In one embodiment, the chaperone protein is an...
US-8,013,128 Antibodies and related molecules that bind to PSCA proteins
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression...
US-8,013,127 Antibody that binds to ER-.alpha.36
The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has...
US-8,013,126 84P2A9: a prostate and testis specific protein highly expressed in prostate cancer
A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it...
US-8,013,125 Metalloproteinase 9 and metalloproteinase 2 binding proteins
Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described.
US-8,013,124 Antibodies to human zcytor17 ligand
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The...
US-8,013,123 Use of precursors of enkephalins and/or their fragments in medical diagnostics
The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials....
US-8,013,122 Method of purifying apolipoprotein A-1
A first method of purifying apolipoprotein A-1 includes mixing plasma fraction IV with a 1-8 M urea solution to form a pretreatment solution; loading the...
US-8,013,121 Isolated nature-identical collagen
The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the...
US-8,013,120 C-reactive protein and its use to treat systemic lupus erythematosus and related conditions
The present invention relates to the use of C-reactive protein, its mutants, metabolites and polypeptides and related compounds thereof for the treatment of...
US-8,013,119 Fluorescent protein
It is an object of the present invention to provide a fluorescent protein, which allows an acceptor for fluorescence resonance energy transfer (FRET) to appear...
US-8,013,118 Lynx polypeptides
The present invention provides a novel family of polypeptides which are ligand-gated channel receptor accessory molecules or ligands, denoted Lynx. This...
US-8,013,117 Solution-phase synthesis of leuprolide and its intermediates
A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by...
US-8,013,116 Therapeutic peptides and method
A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterized by the ability to treat, ameliorate, or lessen the...
US-8,013,115 Use of stabilised synthetic compounds in immunoassay
The invention concerns the use of at least a synthetic compound comprising: a carrier molecule having at least a hydrocarbon chain comprising at least 10,...
US-8,013,114 Fusion proteins based upon somatostatin receptors
The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins...
US-8,013,113 FRET protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of...
US-8,013,112 Compositions comprising human brain natriuretic peptide (BNP) fragments
The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of...
US-8,013,111 Removal of catalyst and/or cocatalyst residues in a polyolefin manufacturing process
The invention relates to an improved process for the manufacture of an olefin polymer composition in which corrosive trace cocatalyst and catalyst residues are...
US-8,013,110 Steam heated polyester production process
Processes for making polyesters in a polyester production facility are disclosed, that include the steps of: forming a reaction medium comprising at least one...
US-8,013,109 Industrially viable method for the production of polycarbynes, polymeric precursors to diamond and diamond like...
This invention is related to a new method of synthesizing polycarbynes. These polymers are known to produce diamond and diamond like ceramics upon heating, by...
US-8,013,108 Process for producing 2, 3, 3', 4',-biphenyltetracarboxylic dianhydride
2,3,3',4'-biphenyltetracarboxylic acid is heat-dehydrated in a molten state at a temperature not lower than 200.degree. C. in a flow of an inert gas in a...
US-8,013,107 Process for producing polyalkylene terephthalate, process for producing polyalkylene terephthalate molding and...
The present invention provides a method of producing polyalkylene terephthalate, which comprises: introducing a prepolymer of polyalkylene terephthalate that is...
US-8,013,106 Optical lens
An optical lens which can be produced by injection molding on an industrial scale, and which has a high refractive index, a low Abbe's number, a low...
US-8,013,105 Flame-retardant polycarbonate resin composition, polycarbonate resin molded article, and method for producing...
Provided are a polycarbonate resin composition containing a glass filler, which is excellent in transparency, strength, and heat resistance and provided with...
US-8,013,104 Thermosetting hyperbranched compositions and methods for use thereof
Hyperbranched polymers and methods for preparing the same are disclosed. The polymers are obtained based on monomers synthesized via reacting a substituted or...
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