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MAPK/ERK kinase inhibitors
Compounds of the following formula are provided for use with MEK: ##STR00001## wherein the variables are as defined herein. Also provided are pharmaceutical...
Compositions and methods for the treatment of cancer
The present invention relates to the use of specific compounds related to the indolocarbazole K252a, for the preparation of pharmaceutical compositions for the...
Betulinic acid derivatives
The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(.dbd.CH.sub.2)CH.sub.3 or CH(CH.sub.3).sub.2; R.sub.2 together with the...
Liquid ganaxolone formulations and methods for the making and use thereof
In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter...
Oral solid dosage forms containing a low dose of estradiol
The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid...
Inhibition of PPAR gamma expression by specific osteogenic oxysterols
This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
Composition for protection and improvement of skin, or reinforcing skin
barrier function comprising...
Disclosed is a composition containing phosphatidylserine as an effective ingredient, and more particularly to a composition containing phosphatidylserine as an...
Compound for inhibiting TRPA1 function and use thereof
The present invention relates to a TRPA1 activation inhibitor, more precisely a TRPA1 activity inhibitor containing isopentenyl pyrophosphate and a method for...
Polysaccharide produced by microorganism belonging to genus
A polysaccharide comprising galactose, glucose, rhamnose, and pyruvic acid as constituents, wherein the galactose, glucose, and rhamnose are contained in a...
Method of treating vitamin B12 deficiency
A novel method and composition for treating vitamin B.sub.12 deficiency mammals that fail to respond to oral vitamin B.sub.12 therapy.
Combination anticancer agents
A cancer therapeutic agent comprising a combination of compound A described below, or a pharmaceutically acceptable salt thereof, and compound B described...
Microsphere-based composition for preventing and/or reversing new-onset
A method is provided that includes using an antisense approach to reverse and/or delay an autoimmune diabetes condition in vivo. The oligonucleotides are...
Inhibitors of TGF-R-signaling for treatment of CNS disorders
The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease,...
Compositions and methods for therapeutic use
A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer...
Ceramide derivatives as modulators of immunity and autoimmunity
.alpha.-Galactosylceramides and glycosylceramides ("ceramide-like glycolipids") that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines...
Composition and methods for the treatment of cancer
The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor...
Prodrug of an ICE inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. ##STR00001## Compound I is useful for treating IL-1 mediated diseases such...
Hydroxyapatite-binding peptides for bone growth and inhibition
Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing...
Immunogenic HER-2 variants
The present invention provides for a novel method for purification of EGFR family proteins obtained from cultures of insect cells. The process comprises...
Composition for acceleration of type I collagen production
It is an object of the present invention to provide a composition for promoting the production of type I collagen by human skin fibroblasts, and the present...
Skin wound healing compositions and methods of use thereof
A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A...
Use of thymosin alpha 1 for the treatment of immunological diseases
It is described the use of thymosin alpha 1 for preparing a medicament useful for the prevention or treatment of graft-versus-host disease or graft rejection...
Y4 selective receptor agonists for therapeutic interventions
Y4 receptor agonist peptide selected from the group consisting of: [Ala30]PP.sub.2-36, [Thr30]PP.sub.2-36, [Asn30]PP.sub.2-36, [Gln30]PP.sub.2-36,...
Combination therapy for the treatment of diabetes and conditions related
thereto and for the treatment of...
The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the...
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the...
Method for customized dispensing of variable dose drug combination
products for individualizing of therapies
The method set out herein involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique...
Liquid composition of factor VII polypeptides
A liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 8.0; (iii)...
Polymer conjugates for a controlled release of active molecules
The present invention relates to the field of perfumery. More particularly, it concerns co-polymers, derived from a maleic anhydride derivative and a ethylenic...
Fabric softening compositions comprising polymeric materials
Fabric softening compositions comprising polymeric materials capable of retaining volatile perfume ingredients are disclosed, as well as methods of softening...
Light duty liquid cleaning compositions and methods of manufacture and use
thereof comprising organic acids
The invention encompasses liquid cleaning compositions, for example, dish washing liquids, and methods of their manufacture and use, which possess enhanced...
Composition comprising a lipase and a bleach catalyst
The present invention relates to a composition comprising: (i) a lipase; and (ii) a bleach catalyst that is capable of accepting an oxygen atom from a...
Odor elimination composition comprising triethylene glycol for use on soft
A method and composition for deodorizing soft surfaces such as carpeting and upholstery are disclosed. The method includes the spraying of a liquid composition...
Heterocoagulate, and compositions and method for polishing and surface
A heterocoagulate comprises first particles, having a particle size of at most 999 nm, on a second particle, having a particle size of at least 3 microns. The...
Functional fluid compositions
A functional fluid comprising a base oil with a high viscosity index, wherein the functional fluid has a kinematic viscosity at 100.degree. C. between 2.5 and...
Lubricating oil additive and lubricating oil composition containing same
A molybdated succinimide complex is disclosed which is prepared by a process comprising (a) reacting a succinimide of a polyamine of formula I: ##STR00001## ...
Lubricating oil additive and lubricating oil composition containing same
A molybdated succinimide complex is disclosed which is prepared by a process comprising (a) reacting an alkyl or alkenyl succinimide of a polyamine of formula I...
Low ash controlled release gels
The present invention relates to a controlled release gel with an ashless component and defined ash-producing component. Further, the invention relates to the...
Universal synthetic penetrating lubricant, method and product-by-process
A penetrating lubricant with the capacity to offer a both penetration into rust and corrosion. Further, this lubricant actively penetrates the crystalline...
Method of making proppant used in gas or oil extraction
Method and system for making a spherical proppant having a selected grade from a naturally occurring mined mineral having a hardness of over 6.0 Mohs. The...
Quaternized dithiazines and method of using same in treatment of wells
Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine or dithiazine of the formula: ...
Method of using dithiazine to inhibit corrosion
Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine of the formula: ##STR00001## ...
Multicomponent viscoelastic surfactant fluid and method of using as a
There is a viscoelastic fluid. The fluid has one or more cationic surfactants selected from the group consisting of certain quaternary salts, certain amines,...
Method of fracturing with phenothiazine stabilizer
Compositions and methods of treating high temperature subterranean formations of up to about 500.degree. F. (260.degree. C.) are provided. The compositions and...
Deep eutectic solvents and applications
A method of solubilizing/removing cellulose or chemically-modified cellulosic polymers utilized in subterranean drilling operations such as fracturing. The...
Method of forming and using solid-phase support
A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the...
Device and method for fabricating thin films by reactive evaporation
A device for fabricating thin films on a substrate includes a vacuum chamber, a rotatable platen configured to hold one or more substrates within the vacuum...
Photocatalyst element, method and device for preparing the same
A photocatalyst according to the invention comprises a photocatalytic film of a compound of titanium and oxygen and is characterized in that the photocatalytic...
NOx storage materials and traps resistant to thermal aging
Nitrogen oxide storage materials and methods of manufacturing nitrogen oxide storage materials are disclosed. The nitrogen oxide storage materials can be used...
Process for synthesizing Li.sub.xFeMZO.sub.4/ carbon and
Li.sub.xMZO.sub.4/ carbon composite materials
The present invention provides a cost effective process of generating Li.sub.xM.sub.yZO.sub.4/carbon composite material. Further, this novel method of...
Hydrogenation catalyst with improved textural properties
A method is provided for making a catalyst support, and includes the steps of providing an aqueous suspension of refractory inorganic oxide and refractory...