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The present invention relates to a compound and a novel process for the preparation of Paricalcitol intermediates.
Glyceryl ether compounds and their use
Glyceryl ether compounds prepared by the reaction of glycerol and olefin epoxides are disclosed. The compounds are renewable biomass-based surfactants useful as...
Process for (3R,
The present invention relates to processes for the manufacture of (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl...
Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-meth-
Novel forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl)- -3-phenyl-4 -[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi ...
Transition metal catalyzed synthesis of N-aminoindoles
The present invention relates to a process for the regioselective synthesis of compounds of the formula I, ##STR00001## wherein R0; R1; R2; R3; R4; R5; R6;...
Process for preparing (meth)acrylic esters of N-hydroxyalkylated
A process for preparing (meth)acrylic esters (F) of N-hydroxyalkylated imidazoles, wherein N-hydroxyalkylated imidazoles (I), ##STR00001## in which R.sup.1...
1,2,3-triazole bound borane compounds, synthesis of, and use in reduction
A 1,2,3-triazole coordinated borane such as ##STR00001## where the B and the R.sup.3 groups can be on any of the three N positions and R.sup.1, R.sup.2,...
Process for the preparation of .epsilon.-alkoxycarbonyllysines and their
A process for the preparation of .omega.-alkoxycarbonylamino-.alpha.-aminoacids and .alpha.,.omega. orthogonally diprotected diaminoacids from...
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of...
Carboxylic acid derivative containing thiazole ring and pharmaceutical use
According to the present invention, a compound represented by the following formula (I) having a superior PPAR.sub..alpha. agonist action and concurrently...
Composition containing thiazole rings, organic semiconductor polymer
containing the composition, organic active...
Disclosed herein is a composition containing hetero arylene or arylene showing a p-type semiconductor property in addition to thiophene showing a p-type...
Hydrazide compounds and thrombopoietin receptor activators
Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided. A...
(R)-arylalkylamino derivatives and pharmaceutical compositions containing
The present invention relates to selected (R)-arylalkylamino derivatives of formula (I), in which R, R1 and Ar are as defined in the claims. These compounds...
Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and
Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical...
4,4-disubstituted piperidine derivatives
This invention relates to 4,4-disubstituted piperidine derivatives of the formula ##STR00001## wherein A and R.sup.1 to R.sup.5 are as defined in the...
A compound having the general structure shown in Formula I: ##STR00001## or pharmaceutically acceptable salt and/or solvates thereof are useful in treating...
Process for producing coelenteramide or an analog thereof
A process for producing coelenteramide or its analog in a high yield has been desired. The invention provides a process for producing di-O-methylcoelenteramide...
Non-nucleoside reverse transcriptase inhibitors
Compounds of formula I, wherein R.sup.1, X.sup.1, X.sup.2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse...
Isoindoline pigments of the general formula I ##STR00001## in which the variables are defined as follows: R.sup.1 is C.sub.1-C.sub.4-alkyl; R.sup.2 is...
Substituted pyridazines as stearoyl-CoA desaturase inhibitors
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal...
Fungicidal heterocyclic amines
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.9a, R.sup.9b, G, W, X, Y, and Z are as...
Process for preparing porphyrin derivatives, such as protoporphyrin (IX)
and synthesis intermediates
The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of...
Cellulose acylate film and its applications
A cellulose acylate film, comprising a cellulose acylate having at least one substituent (Substituent A) comprising an aromatic group having at least one C4 or...
Process for the large scale production of Stavudine
The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3',5'-anhydrothymidine to crude...
Oligomeric compounds for the modulation of survivin expression
Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides,...
Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and
Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have...
Nucleic acid molecules encoding human 4-1BB
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA...
Methods for determining the presence or absence of elite event RF-BN1 in
Brassica plant material
This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, harboring a specific transformation event. It pertains to...
Monocyte-derived nucleic acids and related compositions and methods
Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of...
Tumor suppressor gene, p28ING5
This disclosure provides a novel tumor suppressor, referred to as p28ING5, nucleic acid molecules encoding this protein, and methods of making and using these...
Polynucleotide synthesis labeling chemistry
Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently...
Nucleoside derivative, modified oligonucleotide, method for their
synthesis and applications thereof
Compositions and methods of preparing carboranes and metallacarboranes, which can be used as a new type of electrochemically active label for biological...
Methods and compounds useful for the preparation of sodium glucose
co-transporter 2 inhibitors
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of...
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
Characterization and identification of unique human adiponectin isoforms
The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are...
Targeted binding agents directed to uPAR and uses thereof
Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the...
Antibody modulating the differentiation and function of dendritic cells
via binding intercellular adhesion...
The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the...
Compositions and methods for binding sphingosine-1-phosphate
The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases...
The invention provides a peptide having at least 3 amino acids comprising an amino acid sequence selected from TABLE-US-00001 a) X.sup.1SM [SEQ.ID.NO.:...
High shear oxidation of wax
In this disclosure, a system is described, comprising a shear device with at least one inlet and at least one outlet and a mixing vessel with at least one inlet...
Polysulfone, electrolyte membrane using the same, and fuel cell using the
A polysulfone is provided with a nitrogen-containing functional group having an affinity to an acid, an electrolyte membrane using the polysulfone, and a fuel...
Method for producing polyimide film
A method for producing a polyimide film comprises the steps of: preparing a polar organic solvent solution of a polyimide precursor obtained by mixing a...
Production of a functionalized polytriazole polymer
A method for the production of a functionalized polytriazole polymer, particularly a poly(1,2,4-triazole)-polymer, includes the steps of (a) mixing a hydrazine...
Polycarbonate resin composition and method of producing the same
The present invention relates to a polycarbonate resin composition which comprises a polycarbonate resin having the repeating unit that is represented by the...
Baked resin product and electronic device comprising the same
The present invention provides a baked resin product that exhibits an excellent heat resistance and an electronic device that incorporates this baked resin...
Polyurea and polyurethane compositions for golf equipment
Golf equipment having improved cut and shear resistance that includes a polyurea composition, preferably saturated and/or water resistant, formed of a polyurea...
Protected air-activated organotin catalysts for polyurethane synthesis and
This invention relates to a protected organotin-based catalyst system for polyurethane synthesis that is useful in coatings applications. The catalyst has a...
Sealing material for optical element and sealed optical element
A sealing material for optical elements with excellent transparency, crack resistance, and heat resistance which can produce a cured product of the sealing...
Polymers made from polyhedral oligomeric silsesquioxanes and
A compound having the formula below. Each R is methyl or phenyl; R.sup.2 comprises one or more of silane, siloxane, and aromatic groups; n is a nonnegative...
Organopolysiloxane having carboxyl groups
An organopolysiloxane represented by the following average compositional formula (1): R.sup.1.sub.aR.sup.2.sub.bR.sup.3.sub.cSiO.sub.(4-a-b-c)/2 (1) wherein...