Crystalline form of .gamma.-aminobutyric acid analog
A crystalline form of a .gamma.-aminobutyric acid analog, and methods of preparing same, are provided.
Inhibitors of pyruvate kinase as therapeutic agents for cancer
The present invention relates to compounds for the inhibition of pyruvate kinase and ATP production which are capable of inhibiting cancer cells proliferation.
Flavor composition or fragrance composition, product containing the flavor
composition or fragrance...
Disclosed is a 2-methyl-2-pentenyl ester represented by the general formula (1) [wherein R represents a hydrogen atom or a hydrocarbon group having 1 to 9...
Parenteral CCI-779 formulations containing cosolvents, an antioxidant, and
Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation...
Compositions, methods of use and preparation of 2,6-diisopropyl phenol and
analogs for ischemic injury
The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl...
Use of oxandrolone in the treatment of burns and other wounds
The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount...
8-azaprostaglandin derivative compound and agent comprising the compound
as active ingredient
An 8-azaprostaglandin represented by formula (I) ##STR00001## (wherein all symbols have the same meanings as described in the specification), a ...
Modified lysine-mimetic compounds
Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed.
Formulations of indol-3-yl-2-oxoacetamide compounds
This invention relates to an oral formulation containing an effective amount of the compound of the following formula I: ##STR00001## d-alpha-tocopheryl...
Benzo [F] isoindoles as EP4 receptor agonists
The present invention relates to naphthalene derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in...
Isoindoline compounds and methods of making and using the same
The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or...
Method for scavenging radicals with urocanic acid, derivatives and
The invention relates to antioxidants or radical scavengers and their reaction products. The invention provides compounds and compositions for use in methods...
Non-pegylated liposomal doxorubicin triple combination therapy
The present invention relates to a method for treating metastatic breast cancer in an individual comprising administering to an individual in need thereof a...
Treatment of length dependent neuropathy
Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with...
Heterocycle substituted ketone derivatives as histone deacetylase (HDAC)
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are...
Triazole derivatives as inhibitors of 11-.beta. hydroxysteroid
Triazole derivatives of structural formula I are selective inhibitors of the 11.beta.-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment...
Methods for inhibiting neoproliferative changes in blood vessel walls
Methods, compositions and devices for inhibiting neoproliferative changes in blood vessel walls or other anatomical structures. One or more compounds of Formula...
This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
Fluorinated derivatives of deferiprone
The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or...
Histone deacetylase inhibitors with aryl-pyrazolyl-motifs
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to...
The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical...
Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use
of same in therapeutics
The invention relates to a compound of formula (I): ##STR00001## Wherein m, n, X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined herein. The invention...
Substituted heterocyclic ethers and their use in CNS disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS...
Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
Compounds of formula (I) ##STR00001## are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or...
Substituted piperidines as somatostatin receptor subtype 5 (SSTR5)
This invention is concerned with compounds of the formula ##STR00001## and pharmaceutically acceptable salts thereof. The invention further relates to...
Therapeutic agents useful for treating pain
4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or...
Quinoline inhibitors of HCV polymerase
Compounds having the formula I wherein ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.3 and X.sup.4 and as defined herein...
Large substituent, non-phenolic opioids and methods of use thereof
8-Substituted-2,6-methano-3-benzazocines of general structure ##STR00001## are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and...
Huperzine A and its derivatives as analgesic agents
The present invention relates to a method for treating or alleviating migraines, by administering to a patient in need thereof compound (I), or salts thereof,...
Compositions for delivering highly water soluble drugs
The present invention provides compositions for delivering highly water-soluble drugs (such as vinca alkaloids) and methods of using such compositions.
The present application describes deuterium-enriched topotecan, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
HIV inhibiting pyrimidine derivatives
This invention concerns the use of the compounds of formula ##STR00001## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically...
Bicyclic amides as kinase inhibitors
The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a...
Aurora kinase inhibitors for inhibiting mitotic progression
The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase,...
HIV replication inhibiting purine derivatives
The present invention relates to the use of a compound of formula (I) for the manufacture of a medicament for the prevention or the treatment of HIV infection...
Thioxanthine derivatives and their use as inhibitors of MPO
There are disclosed novel compounds of Formula (I) wherein L, R.sup.1, X and Y are as defined in the specification, and pharmaceutically acceptable salts...
[4,5']Bipyrimidinyl-6,4'-diamine derivatives as protein kinase inhibitors
The invention provides a novel class of compounds of the Formula I: ##STR00001## in which the symbols have the meanings given in the description and claims, to...
Cyclopropyl amines as modulators of the histamine H.sub.3 receptor
Certain cyclopropyl amines are histamine H.sub.3 modulators useful in the treatment of histamine H.sub.3 receptor mediated diseases.
Vanilloid receptor ligands and their use in treatments
Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache,...
The invention relates to octahydro-pyrrolo[3,4-b]pyrrole N-oxides as prodrugs of CNS-active compounds, compositions comprising such compounds, methods for...
Cell differentiation inducer
A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast...
Topical antifungal composition
A topical, foamable composition is provided that includes at least one antifungal agent that is able to penetrate the upper layers of skin and is retained in or...
Pyrrole derivatives as pharmaceutical agents
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating...
The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I ##STR00001## to pharmaceutical...
Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the
same, and use thereof
Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a...
Polo-like kinase inhibitors
Compounds of the following formula are provided for use with kinases: ##STR00001## wherein the variables are as defined herein. Also provided are...
P38 inhibitors and methods of use thereof
Compounds of formula (I): in which A, B, X, Ar.sup.1, R.sup.8 and R.sup.4 have any of the meanings given in the specification, are inhibitors of p38 useful in...
Benzothiophene oxide derivative and salt thereof
Disclosed is a benzothiophene oxide derivative represented by the general formula (wherein R.sup.1 and R.sup.2 are the same or different and each represents one...
Aminothiolester compounds, pharmaceutical and cosmetic compositions
containing same and uses thereof
The invention relates to novel aminothiol ester compounds having the general formula (I): ##STR00001## and to a method for preparing them and to their use in...
Methods and compositions for treating cancer using proteasome inhibitors
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The...