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Patent # Description
US-8,048,926 L-DOPA amide derivatives and uses thereof
L-DOPA amide derivatives, pharmaceutical compositions containing same and their use in the treatment of conditions associated with impaired dopaminergic...
US-8,048,925 Bis(thio-hydrazide amide) salts for treatment of cancers
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): ##STR00001## Y is a covalent bond or a substituted or...
US-8,048,924 Methods and compositions employing 4-aminophenylacetic acid compounds
The invention provides compositions comprising 4-APAA compounds and methods for treating disorders involving inflammation of the intestinal system, such as...
US-8,048,923 Treatment of polyglutamine disorders caused by expanding genomic CAG nucleotides
The present invention relates to the treatment or prevention of neurodegenerative polyglutamine diseases by the administration of effective amounts of...
US-8,048,922 Compositions and methods for treating feline inflammatory bowel disease
Compositions comprising eicosapentaenoic acid and docosahexaenoic acid in a ratio of from 1.2 to 2 are administered to felines to treat feline inflammatory...
US-8,048,921 Amino acid compounds
Carnitine and Taurine Compounds are described. The Carnitine Compound comprises Carnitine and one of a Nitrate and a Nitrite. The Taurine Compound comprises...
US-8,048,920 Personal care composition containing bio-derived 1,3-propanediol and its conjugate esters
Biodegradable personal care compositions comprising 1,3-propanediol are provided, and the 1,3-propanediol in the composition is biologically derived. The...
US-8,048,919 Use of ethyl lactate as an excipient for pharmaceutical compositions
This invention is based upon the unexpected discovery that ethyl lactate can be used as an emulsifying/dispersing excipient for numerous biologically active...
US-8,048,918 Treatment of hyperproliferative diseases
We describe methods and compositions for treating a patient suffering from a hyperproliferative disorder or photoageing. Our methods involve blocking the...
US-8,048,917 Prodrugs of GABA analogs, compositions and uses thereof
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA...
US-8,048,916 Ester compound and use thereof
A compound represented by the formula (I): ##STR00001## has an excellent pest controlling activity and therefore is useful for an effective ingredient of a...
US-8,048,915 Biologically active complex
The invention relates to an aqueous solution containing at least one species selected from the group consisting of a 1:1 molar complex of TeO.sub.2 with a...
US-8,048,914 Methods for isolation of triptolide compounds from Tripterygium wilfordii
Methods for extraction, isolation, and purification of therapeutically useful compounds from Tripterygium wilfordii are described. Extraction steps employing...
US-8,048,913 Compositions and products containing S-equol, and methods for their making
A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of...
US-8,048,912 Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their...
The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-.beta. receptor which can be effectively used as a...
US-8,048,911 Melanin eliminator preparation
A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I), ##STR00001## wherein M denotes a metal, and R...
US-8,048,910 Combination of R,R-glycopyrrolate, rolipram, and budesonide for the treatment of inflammatory diseases
Novel combinations based on anticholinergics, .beta..sub.2-adrenoceptor agonists, PDE 4 Inhibitors, glucocorticoids, and leukotriene-receptor antagonists,...
US-8,048,909 Proton pump inhibitors
A proton pump inhibitor containing a compound represented by the formula (I) ##STR00001## wherein X and Y are the same or different and each is a bond or a...
US-8,048,908 11.beta.-hydroxysteroid dehydrogenase type 1 active compounds
The use of substituted amides for modulating the activity of 11.beta.-hydroxysteroid dehydrogenase type 1 (11.beta.HSD1) and the use of these compounds as...
US-8,048,907 Receptor antagonists and their methods of use
The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the...
US-8,048,906 Optically pure and enriched isomers of chelating ligands and contrast agents
Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described,...
US-8,048,905 Tetrazole-substituted arylamides as P2X.sub.3 and P2X.sub.2/3 antagonists
Compounds of the formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is optionally substituted tetrazolyl, R.sup.2 is...
US-8,048,904 Process for the preparation of olmesartan medoxomil
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl ...
US-8,048,903 5-iodotetrazoles
The compounds of the formula (I) ##STR00001## in which R.sup.1 represents hydrogen or in each case optionally substituted alkyl, alkenyl, alkynyl or phenyl...
US-8,048,902 Antagonists of lysophosphatidic acid receptors
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include...
US-8,048,901 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups, processes for their...
The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and...
US-8,048,900 Use of 15-lipoxygenase inhibitors for treating obesity
The invention concerns the treatment of obesity, in particular abdominal visceral obesity. More specifically, the invention concerns the use of selective...
US-8,048,899 Compounds which selectively modulate the CB2 receptor
##STR00001## are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful...
US-8,048,898 Inhibitor of binding of S1P.sub.1
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## (wherein Y.sup.1 represents a nitrogen atom or a group...
US-8,048,897 Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug...
US-8,048,896 Methods for inhibiting and breaking AGE complex formation
Various methods of administering medication(s) that inhibit the nonenzymatic formation of glycation and dehydration condensation complexes known as advanced...
US-8,048,895 Kappa opioid receptor ligands
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these...
US-8,048,894 Quinolones and azaquinolones that inhibit prolyl hydroxylase
Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: ##STR00001## where the...
US-8,048,893 Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and...
The present invention relates to the novel derivatives of formula (I) in which ##STR00001## A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a...
US-8,048,892 Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
##STR00001## are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.
US-8,048,891 Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
The present invention relates to methods of treatment of non-Hodgkin's lymphomas. The present invention includes administering polymeric prodrugs of...
US-8,048,890 Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods
Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions,...
US-8,048,889 3,4-disubstituted coumarin and quinolone compounds
The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods...
US-8,048,888 Anti-proliferative combination therapy using certain platinum-based chemotherapeutic agents and EGFR inhibitors...
The present invention describes a method or uses of prevention and/or treatment of a cancer or a tumor, and in particular to a combination therapy, methods,...
US-8,048,887 Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
US-8,048,886 Substituted pyrazine-3-one-derivatives as IAP inhibitors
The present invention relates to novel IAP inhibitor compounds of formula I: ##STR00001##
US-8,048,885 Organic compounds
The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I) wherein the substituents are as defined in the specification and to processes for...
US-8,048,884 Substituted piperazinyl pyrazines and pyridines as 5-HT.sub.7 receptor antagonists
The present invention provides selective 5-HT.sub.7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: ##STR00001## where A...
US-8,048,883 Polymorphic form of imatinib mesylate and a process for its preparation
This invention discloses a novel stable crystal form of imatinib mesylate, designated by us as .alpha..sub.2 Form, which is stable at room temperature and even...
US-8,048,882 Pharmaceutical compositions with increased activity
The invention relates to novel pharmaceutical combinations with improved sodium channel blocking effect. Further, the invention relates to the use of said...
US-8,048,881 Pyrimidine derivatives and their use as P2Y12 receptor antagonists
The invention relates to 4-aminocarbonyl-pyrimidine derivatives and their use as P2Y.sub.12 receptor antagonists in the treatment and/or prevention and/or...
US-8,048,880 Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A.sub.2 (SPLA.sub.2)...
Administration of sPLA.sub.2 inhibitors has been found to decrease cholesterol levels, atherosclerotic plaque formation and aortic aneurysm in mice, and to...
US-8,048,879 Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments
The present invention relates to substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compound corresponding to formula I, methods for producing them, to...
US-8,048,878 Two cyclic cinnamide compound
The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two...
US-8,048,877 Guanidine derivatives and their medical use
This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other...
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