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Patent # Description
US-8,067,584 Benzothiazepine derivatives
Compounds of formula: (1) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport...
US-8,067,583 Method for synthesizing furanosteroids
The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization...
US-8,067,582 Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function
Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using...
US-8,067,581 Biomolecules having multiple attachment moieties for binding to a substrate surface
Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: ...
US-8,067,580 Isolation of DNA, RNA and protein from a single sample
The invention provides a method for the separation and purification of two or three cellular components selected from genomic DNA, RNA and proteins from a...
US-8,067,579 Nucleic acid extraction method
The present invention relates to a method for isolating nucleic acids from a nucleic acid containing sample, and a kit for carrying out said method. More...
US-8,067,578 Substrate preparation process
The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of...
US-8,067,577 Methods and compositions for the treatment of intestinal conditions
Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also...
US-8,067,576 siRNA targeting serine/threonine kinase 12 (STK12 or aurora B kinase)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize...
US-8,067,575 RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
This invention relates to compounds, compositions, and methods useful for modulating cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) gene...
US-8,067,574 Nucleic acid agents for downregulating H19, and methods of using same
Isolated oligonucleotides capable of down-regulating H19 mRNA in cancer cells are disclosed, as well as pharmaceutical compositions that include the...
US-8,067,573 Nucleic acid agents for downregulating H19 and methods of using same
The present invention provides isolated oligonucleotides capable of down-regulating a level of H19 mRNA in cancer cells. Articles of manufacture comprising...
US-8,067,572 Hybrid interfering RNA
The invention relates to a hybrid interfering RNA molecule comprising a duplex RNA and a single stranded DNA molecule and its use in the ablation of mRNA and in...
US-8,067,571 Antibacterial antisense oligonucleotide and method
A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by ...
US-8,067,570 Therapeutic uses of inhibitors of RTP801
The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases respiratory conditions and...
US-8,067,569 Splice-region antisense composition and method
Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5' end from 1 to about 25 base pairs downstream...
US-8,067,568 Method for diagnosing spinal muscular atrophy
A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene,...
US-8,067,567 Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same
The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the...
US-8,067,566 Dengue serotype 2 attenuated strain
The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681...
US-8,067,565 Dengue serotype 1 attenuated strain
The invention relates to live attenuated VDV1 (VERO-Derived Dengue serotype 1 virus) strains which have been derived from the wild-type dengue-1 strain 16007 by...
US-8,067,564 Methods of obtaining a specific binding member that binds eotaxin
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which...
US-8,067,563 Tumor suppressor gene, p471NG3
The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of...
US-8,067,562 Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The...
US-8,067,561 Isolated DNA encoding recombinant glucose isomerase
This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability...
US-8,067,560 SRSV detection kit
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide...
US-8,067,559 Yeast-based vaccines as immunotherapy
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular...
US-8,067,558 Constitutively active fragments of eukaryotic heat shock RNA
The present invention provides a novel RNA, designated herein as the "HSR1" (Heat Shock RNA), constitutively active HSR1 fragments, and the use of HSR1 and...
US-8,067,557 OCL-2A3 compositions and uses thereof
This invention relates to osteoclast-specific genes and proteins. Specifically, the invention relates to OCL-2A3 or Atp6v0d2, the gene encoding it and uses...
US-8,067,556 Multi-site mutagenesis
The present invention provides compositions and improved methods for multi-site directed mutagenesis and DNA shuffling. The present compositions and methods...
US-8,067,555 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic...
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) ##STR00001## where...
US-8,067,554 Ion exchange chromatography of GLP-1, analogs and derivatives thereof
The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said...
US-8,067,553 PEG-urate oxidase conjugates and use thereof
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG),...
US-8,067,552 Method for preparing a target protein using the sHSPs
The present invention relates to a method for separating and purifying a target protein, a method for preparing a target protein, and a method for bioconversion...
US-8,067,551 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of...
US-8,067,550 Hybridomas producing antibodies against non functional P2X7 receptor
The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines.
US-8,067,549 Humanized antibodies and compositions for binding sphingosine-1-phosphate
The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive...
US-8,067,548 Fusion proteins having mutated immunoglobulin hinge region
A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a...
US-8,067,547 Stable and soluble antibodies inhibiting TNF.alpha.
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF.alpha., which comprise specific light chain...
US-8,067,546 Humanized anti-CD70 binding agents and uses thereof
Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory...
US-8,067,545 Isolated antibodies against biologically active leptin-related peptides
The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more...
US-8,067,544 Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human...
US-8,067,543 Factor VIII polymer conjugates
The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor...
US-8,067,542 Amino acid sequence variant alfalfa antifungal protein and its use in plant disease control
The present invention relates to an antifungal protein, AlfAFP1, which is a modified form of an antifungal protein isolated from Medicago plants, the modified...
US-8,067,541 Highly thermostable fluorescent proteins
Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and...
US-8,067,540 Human ALEX1 proteins
The present invention provides a novel protein containing an armadillo repeat, a gene encoding this protein, and production and use thereof. The present...
US-8,067,539 T1R taste receptors and genes encoding same
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G...
US-8,067,538 Gene related to growth promoting function of acetic acid bacterium, acetic acid bacterium bred using the gene...
The present invention is to obtain a novel gene that encodes a protein having a function of promoting acetic acid bacterial growth in the presence of a high...
US-8,067,537 Composition and method for treatment of stomatitis
A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable...
US-8,067,536 Kinase and phosphatase assays
Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The...
US-8,067,535 Identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Three vaccinia virus...
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