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Patent # Description
US-8,067,434 Compounds and methods for development of Ret modulators
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined...
US-8,067,433 Methods, compositions, and kits for the treatment of ophthalmic disorders
The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with...
US-8,067,432 Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors
A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes...
US-8,067,431 Chemically modified small molecules
Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a...
US-8,067,430 Anti-HIV activity of the opioid antagonist naloxone
A method of treating HIV infection by using the novel anti-HIV activity of the opioid antagonist naloxone.
US-8,067,429 Forms of rifaximin and uses thereof
The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods...
US-8,067,428 Platelet ADP receptor inhibitors
Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine...
US-8,067,427 Pharmaceutical compositions comprising ZD6474
A pharmaceutical composition comprising ZD6474 or a pharmaceutically acceptable salt thereof, a brittle diluent and a second diluent which is practically...
US-8,067,426 6-amino-purin-8-one compounds
Compounds of formula (I): ##STR00001## wherein R.sup.1 is C.sub.1-6alkylamino, C.sub.1-6alkoxy, or C.sub.3-7cycloalkyloxy; m is an integer having a value of 3...
US-8,067,425 Neuroprotective bicyclic compounds and methods for their use
Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are...
US-8,067,424 Selective inhibitors for cyclin-dependent kinases
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in...
US-8,067,423 Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof
The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ...
US-8,067,422 Crystal form of phenylamino pyrimidine derivatives
The present invention relates to a particular form of the (3,5-bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]- -benzamide (formula...
US-8,067,421 Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as...
Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are...
US-8,067,420 Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I...
US-8,067,419 Piperazines as antimalarial agents
The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
US-8,067,418 Tricyclic angiotensin II agonists
There is provided compounds of formula I, ##STR00001## wherein the dotted line, X.sub.1, X.sub.2, X.sub.3, A, Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Z.sub.1,...
US-8,067,417 Imidazo[1,2-F]pteridines useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinase, represented by Structural Formula (I): ##STR00001## wherein the variables in...
US-8,067,416 Methods and compositions for the treatment of metabolic disorders
The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the...
US-8,067,415 Compounds useful as antagonists of CCR2
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R.sup.1 are defined...
US-8,067,414 Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
The invention provides compositions and kits comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt...
US-8,067,413 9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 ) modulators
The present invention provides compounds of formula (I) ##STR00001## wherein R.sup.1, Y.sup.1, X.sup.1, L and R.sup.2 are as defined in the specification, and...
US-8,067,412 Macrocyclic compounds useful as inhibitors of kinases and HSP90
Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the...
US-8,067,411 Compounds
The present invention provides compounds of formula ##STR00001## wherein R.sup.1, Y.sup.1, X.sup.1, Z.sup.1, X.sup.2, Y.sup.2, A, n and R.sup.2 are as defined...
US-8,067,410 Phenolic and catecholic amines and prodrugs thereof
The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing...
US-8,067,409 Protein kinase inhibitors
Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
US-8,067,408 Dual pharmacophores--PDE4-muscarinic antagonistics
The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of...
US-8,067,407 Substituted dihydropyrazolones and their use
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis...
US-8,067,406 Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
An alkyl ether derivative represented by the following general formula [1] ##STR00001## or its salt: wherein R.sup.1 and R.sup.2 represent each a substituent...
US-8,067,405 Superoxide dismutase mimics for the treatment of ocular disorders and diseases
The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
US-8,067,404 Phthalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and...
Phthalocyanine derivatives are described having photosensitizing characteristics and high solubility in water, useful for photodynamic treatment of bacterial...
US-8,067,403 Methods and systems for preparing an antimicrobial composition
A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic...
US-8,067,402 Methods and systems for coating an oral surface
A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic...
US-8,067,401 Compounds and compositions for treating infection
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are...
US-8,067,400 Androgen treatment in females
A method of improving cumulative embryo score may comprise administering an androgen to a human female for at least about four consecutive months followed by...
US-8,067,399 Method and apparatus for transdermal or transmucosal application of testosterone
Methods, formulations, and devices for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods...
US-8,067,398 Biodegradable polymers having a pre-determined chirality
Optically active polymers that are composed of monomer residues derived from chiral pre-polymerized monomers, which maintain the chirality of the ...
US-8,067,397 Transdiscal administration of cycline compounds
The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.
US-8,067,396 Amino alcohol compounds or phosphonic acid derivatives thereof
A compound having a formula II(a): ##STR00001## wherein R.sup.1 and R.sup.2 are hydrogen lower alkyl, lower aliphatic acyl, or lower alkoxycarbonyl; R.sup.4...
US-8,067,395 Inhibitors of tyrosine kinases and uses thereof
Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also...
US-8,067,394 Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these...
US-8,067,393 Sugar-immobilized metal nanoparticle, method for measuring sugar-protein interaction using the same and method...
It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein...
US-8,067,392 Compositions and methods for treatment of mitochondrial diseases
Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a...
US-8,067,391 ODCase inhibitors for the treatment of malaria
The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives...
US-8,067,390 Therapeutic targeting of interleukins using siRNA in neutral liposomes
The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides compositions that...
US-8,067,389 Silencing of TGF.beta. type II receptor expression by siRNA
The present application is directed to siRNA-based silencing of the type II receptor of TGF.beta.. siRNAs that target this receptor abrogate the receptor...
US-8,067,388 Decoy-containing pharmaceutical compositions and method of using the same
A pharmaceutical composition is provided for treatment and prevention of a disease caused by expression of a gene controlled by NF-.kappa.B or ets. The...
US-8,067,387 Method for stimulating angiogenesis using DKK2 and composition comprising the same
The present invention relates to a method for stimulating angiogenesis using by DKK2 and composition comprising the same. The DKK2 protein of the present...
US-8,067,386 Modulation of eIF4E-BP2 expression
Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic...
US-8,067,385 Antiviral oligonucleotides targeting HBV
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are...
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