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| Patent # | Description |
|---|---|
| US-8,067,434 |
Compounds and methods for development of Ret modulators Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined... |
| US-8,067,433 |
Methods, compositions, and kits for the treatment of ophthalmic disorders The invention features methods, kits, and compositions for the treatment of ophthalmic disorders. The compositions include a corticosteroid in combination with... |
| US-8,067,432 |
Liposomal, ring-opened camptothecins with prolonged, site-specific
delivery of active drug to solid tumors A method for preparing a stable dispersion of a camptothecin, camptothecin prodrug, or analog thereof for administration to a patient in need thereof includes... |
| US-8,067,431 |
Chemically modified small molecules Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a... |
| US-8,067,430 |
Anti-HIV activity of the opioid antagonist naloxone A method of treating HIV infection by using the novel anti-HIV activity of the opioid antagonist naloxone. |
| US-8,067,429 |
Forms of rifaximin and uses thereof The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods... |
| US-8,067,428 |
Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine... |
| US-8,067,427 |
Pharmaceutical compositions comprising ZD6474 A pharmaceutical composition comprising ZD6474 or a pharmaceutically acceptable salt thereof, a brittle diluent and a second diluent which is practically... |
| US-8,067,426 |
6-amino-purin-8-one compounds Compounds of formula (I): ##STR00001## wherein R.sup.1 is C.sub.1-6alkylamino, C.sub.1-6alkoxy, or C.sub.3-7cycloalkyloxy; m is an integer having a value of 3... |
| US-8,067,425 |
Neuroprotective bicyclic compounds and methods for their use Embodiments of this invention provide novel cyclic compounds structurally related to diketopiperazines and methods for their therapeutic use. Such compounds are... |
| US-8,067,424 |
Selective inhibitors for cyclin-dependent kinases This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in... |
| US-8,067,423 |
Polymorphs of dasatinib isopropyl alcohol and process for preparation
thereof The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ... |
| US-8,067,422 |
Crystal form of phenylamino pyrimidine derivatives The present invention relates to a particular form of the (3,5-bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]- -benzamide (formula... |
| US-8,067,421 |
Polymorphic forms of imatinib mesylate and processes for preparation of
novel crystalline forms as well as... Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are... |
| US-8,067,420 |
Substituted pyrazinone melanin concentrating hormone receptor-1
antagonists and methods The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I... |
| US-8,067,419 |
Piperazines as antimalarial agents The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also... |
| US-8,067,418 |
Tricyclic angiotensin II agonists There is provided compounds of formula I, ##STR00001## wherein the dotted line, X.sub.1, X.sub.2, X.sub.3, A, Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Z.sub.1,... |
| US-8,067,417 |
Imidazo[1,2-F]pteridines useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase, represented by Structural Formula (I): ##STR00001## wherein the variables in... |
| US-8,067,416 |
Methods and compositions for the treatment of metabolic disorders The present invention is directed to a novel methods and compositions for the therapeutic intervention in hyperphenylalaninemia. More specifically, the... |
| US-8,067,415 |
Compounds useful as antagonists of CCR2 The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R.sup.1 are defined... |
| US-8,067,414 |
Nitric oxide enhancing prostaglandin compounds, compositions and methods
of use The invention provides compositions and kits comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt... |
| US-8,067,413 |
9-substituted-8-oxo-adenine compounds as toll-like receptor (TLR7 )
modulators The present invention provides compounds of formula (I) ##STR00001## wherein R.sup.1, Y.sup.1, X.sup.1, L and R.sup.2 are as defined in the specification, and... |
| US-8,067,412 |
Macrocyclic compounds useful as inhibitors of kinases and HSP90 Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the... |
| US-8,067,411 |
Compounds The present invention provides compounds of formula ##STR00001## wherein R.sup.1, Y.sup.1, X.sup.1, Z.sup.1, X.sup.2, Y.sup.2, A, n and R.sup.2 are as defined... |
| US-8,067,410 |
Phenolic and catecholic amines and prodrugs thereof The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing... |
| US-8,067,409 |
Protein kinase inhibitors Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. |
| US-8,067,408 |
Dual pharmacophores--PDE4-muscarinic antagonistics The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of... |
| US-8,067,407 |
Substituted dihydropyrazolones and their use The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis... |
| US-8,067,406 |
Preventive/remedy for retinal nerve diseases containing alkyl ether
derivatives or salts thereof An alkyl ether derivative represented by the following general formula [1] ##STR00001## or its salt: wherein R.sup.1 and R.sup.2 represent each a substituent... |
| US-8,067,405 |
Superoxide dismutase mimics for the treatment of ocular disorders and
diseases The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed. |
| US-8,067,404 |
Phthalocyanine derivatives, process for their preparation, pharmaceutical
compositions containing them and... Phthalocyanine derivatives are described having photosensitizing characteristics and high solubility in water, useful for photodynamic treatment of bacterial... |
| US-8,067,403 |
Methods and systems for preparing an antimicrobial composition A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic... |
| US-8,067,402 |
Methods and systems for coating an oral surface A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic... |
| US-8,067,401 |
Compounds and compositions for treating infection Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are... |
| US-8,067,400 |
Androgen treatment in females A method of improving cumulative embryo score may comprise administering an androgen to a human female for at least about four consecutive months followed by... |
| US-8,067,399 |
Method and apparatus for transdermal or transmucosal application of
testosterone Methods, formulations, and devices for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods... |
| US-8,067,398 |
Biodegradable polymers having a pre-determined chirality Optically active polymers that are composed of monomer residues derived from chiral pre-polymerized monomers, which maintain the chirality of the ... |
| US-8,067,397 |
Transdiscal administration of cycline compounds The present invention relates to administering a doxycycline compound into a diseased intervertebral disc. |
| US-8,067,396 |
Amino alcohol compounds or phosphonic acid derivatives thereof A compound having a formula II(a): ##STR00001## wherein R.sup.1 and R.sup.2 are hydrogen lower alkyl, lower aliphatic acyl, or lower alkoxycarbonyl; R.sup.4... |
| US-8,067,395 |
Inhibitors of tyrosine kinases and uses thereof Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also... |
| US-8,067,394 |
Synthesis and biological activities of new tricyclic-bis-enones (TBEs) This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these... |
| US-8,067,393 |
Sugar-immobilized metal nanoparticle, method for measuring sugar-protein
interaction using the same and method... It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein... |
| US-8,067,392 |
Compositions and methods for treatment of mitochondrial diseases Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a... |
| US-8,067,391 |
ODCase inhibitors for the treatment of malaria The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives... |
| US-8,067,390 |
Therapeutic targeting of interleukins using siRNA in neutral liposomes The present invention relates to the fields of molecular biology and drug delivery. In certain embodiments, the present invention provides compositions that... |
| US-8,067,389 |
Silencing of TGF.beta. type II receptor expression by siRNA The present application is directed to siRNA-based silencing of the type II receptor of TGF.beta.. siRNAs that target this receptor abrogate the receptor... |
| US-8,067,388 |
Decoy-containing pharmaceutical compositions and method of using the same A pharmaceutical composition is provided for treatment and prevention of a disease caused by expression of a gene controlled by NF-.kappa.B or ets. The... |
| US-8,067,387 |
Method for stimulating angiogenesis using DKK2 and composition comprising
the same The present invention relates to a method for stimulating angiogenesis using by DKK2 and composition comprising the same. The DKK2 protein of the present... |
| US-8,067,386 |
Modulation of eIF4E-BP2 expression Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic... |
| US-8,067,385 |
Antiviral oligonucleotides targeting HBV Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are... |
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