Stable compositions of famotidine and ibuprofen
Stable pharmaceutical compositions of famotidine and ibuprofen in a single unit dosage form are disclosed herein. The compositions comprise a famotidine core...
Method for preparing submicron particles of antineoplastic agents
The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the...
Compositions and systems for forming crosslinked biomaterials and
associated methods of preparation and use
Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible,...
Controlled release composition and method of producing the same
A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable...
Rapidly disintegrating gelatinous coated tablets
The present invention relates to an improved gelatinous coated dosage form having two end regions coated with gelatinous materials and an exposed...
Drug delivery device
Drug delivery devices are provided herein including crosslinked polymeric compositions. The devices may, in embodiments, possess at least two drug release...
Tissue augmentation material and method
A material and method for augmenting soft tissue. The tissue augmentation material consists essentially of water and a polysaccharide gel former selected from...
Drug release regions for medical devices, which include
According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control...
Nitric oxide generating medical devices
Medical devices having a catalyst capable of catalyzing the generation of nitric oxide attached to the medical device and methods of treating a vascular...
Medical devices to prevent or inhibit restenosis
Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain...
Implantable medical devices incorporating plasma polymerized film layers
and charged amino acids
An implantable medical device, such as a stent, is disclosed comprising an amino acid or a polypeptide bonded to a plasma polymerized film layer formed on the...
Therapeutic inhibitor of vascular smooth muscle cells
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically...
Methods and compositions for delivery of growth factor to fibrous
The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a...
Sustained release formulation
A composition comprises a protein, a polyol, and a metal. The protein is stabilized by the polyol and the metal, and is protected from denaturing when in...
Wax treated burnable dispensing substrates
Disclosed herein are burnable air treatment chemical dispensing substrates, such as mosquito coils, in which wax is incorporated. In one form the wax portion is...
A microcapsule comprising a core material containing pyrethrin and a capsule shell wall which surrounds said core material, said shell wall material comprises...
Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and...
Fusion proteins of Mycobacterium tuberculosis
The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding...
Methods and compositions for the treatment and prevention of
Staphylococcus and other bacterial infections
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria,...
Chimeric AAV capsid proteins
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a...
Multivalent avian influenza vaccines
A vaccine composition and method which is effective in preventing or ameliorating Avian Influenza Virus infection is set forth herein. The vaccine contains at...
Treatment of melanoma using HSV mutant
Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the .gamma.34.5 gene in the long repeat region...
Compositions and methods for treating B-cell malignancies
The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.
Immunological herpes simplex virus antigens and methods for use thereof
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent...
Metalloproteinase oligopeptides and their therapeutic use
The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides and peptidomimetics. The oligopeptides are used for making...
Peptide inhibitors for mediating stress responses
The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions...
Compositions and methods for identifying and targeting cancer cells of
alimentary canal origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of...
Polymeric carriers of therapeutic agents and recognition moieties for
antibody-based targeting of disease sites
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the...
Divalent antibody fragments
Divalent antibody fragments are described, each of which has one or more interchain bridges containing a synthetic or naturally occurring polymer selected from...
The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this...
Methods of treating conditions using anti-IL-6 antibodies
Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic...
Humanized anti-factor D antibodies
The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor...
Antibody selective for a tumor necrosis factor-related apoptosis-inducing
ligand receptor and uses thereof
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell...
Cancer treatment with endothelin receptor antagonists
The present invention relates to therapeutic protocols and pharmaceutical compositions designed to treat and prevent cancer. More specifically, the present...
PEGylated A.beta. fab
A method to treat conditions associated with A.beta. peptide activity both prophylactically and therapeutically is described. The method employs humanized...
Antibodies for norovirus
Norovirus antigen peptides are described having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-16, or fragments thereof. Such...
Modulation of activity of neurotrophins
The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (NGF), brain derived...
Anti-CCR7 receptor antibodies for the treatment of cancer
Antibodies, or antigen-binding fragment thereof, which bind to a CCR7 receptor are capable of selectively killing, impairing migration and/or blocking...
Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, ...
Proteins comprising an IgG2 domain
Disclosed are methods and compositions for efficiently expressing antibody fusion proteins. Antibody fusion proteins of the invention include a hybrid antibody...
Use of ventricular enlargement rate in intravenous immunoglobulin
treatment of Alzheimer's disease
The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease...
Medicament and a method of treating a pathological syndrome
A medicament based on antibodies contains an activated form of monoclonal, polyclonal, or natural antibodies to interferon in low or ultra-low doses prepared by...
Enzyme inhibitors of PAI-1
The invention provides a method for the treatment of a subject suffering from a cardiovascular disease using a therapeutically effective amount of at least one...
Lysin protein having broad antibacterial activity specific to bacteria
The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by...
Method of treating tumor growth and metastasis by using trifunctional
antibodies to reduce the risk for GvHD in...
The present invention refers to a method of treating tumor growth and metastasis in a mammal, the treating comprising administering allogeneic effector cells...
In-hive trap and lure for control of the small hive beetle, Aethina tumida
A Small Hive Beetle trap, which replaces the bottom board of beehives, includes a frame having three walls and a top surface, a trap plate, an entry means, and...
Bacterial delivery of biologically active polypeptides
The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonizing non-pathogenic Gram negative bacteria....
Formulations including digestive enzymes and polysorbate surfactants that
enhance the colonization of...
Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and...
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so...
Modified vaccinia virus strains for use in diagnostic and therapeutic
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods...