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Patent # Description
US-8,071,781 Process for preparing rabeprazole sodium
The present invention provides a process for preparing the amorphous rabeprazole sodium. The process comprises the following steps: (a) Contacting rabeprazole...
US-8,071,780 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide
The present invention provides novel piperidine derivatives of formula (I), ##STR00001## wherein R represents a substituted benzyl group, which are useful...
US-8,071,779 Cytoskeletal active rho kinase inhibitor compounds, composition and use
The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also...
US-8,071,778 Substituted heterocyclic ethers and their use in CNS disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS...
US-8,071,777 Compounds derived from artesunate, preparation process, pharmaceutical composition and use of the respective...
The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the...
US-8,071,776 Thienopyridines as allosteric potentiators of the M4 muscarinic receptor
The present invention relates to selective allosteric potentiators of the Formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, for the...
US-8,071,775 Substituted rylene derivatives
Rylene derivatives of the general formula I ##STR00001## in which the variables are each defined as follows: Rylene is a polycyclic conjugated ring system...
US-8,071,774 Heterocyclic spiro-compounds as aldosterone synthase inhibitors
The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R.sup.1, R.sup.2, U, V, W, X, Y, Z, n and p have the...
US-8,071,773 Heterocyclic spiro-compounds as aldosterone synthase inhibitors
The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R.sup.1, R.sup.2, W, X, Y, Z and n have the definitions...
US-8,071,772 Spirolactam bicyclic CGRP receptor antagonists
Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,...
US-8,071,771 Bicyclic spirohydantoin CGRP receptor antagonists
Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,...
US-8,071,770 Spirohydantoin aryl CGRP receptor antagonists
Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,...
US-8,071,769 Aromatic monomer- and conjugated polymer-metal complexes
A halogenated aromatic monomer-metal complex useful for preparing a polymer for electronic devices such as a light-emitting diode (LED) device is described. The...
US-8,071,768 Alkylquinoline and alkylquinazoline kinase modulators
The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, B, Z, G, Q and X are...
US-8,071,767 Process for preparation of 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one hydrochloride
Described herein is an improved, commercially viable and industrially advantageous process for the preparation of paliperidone intermediate ...
US-8,071,766 HSP90 inhibitors
The invention relates to HSP90 inhibiting compounds consisting of the formula: ##STR00001## wherein the variables are as defined herein. The invention also...
US-8,071,765 Process for the preparation of sildenafil and intermediates thereof
The present invention discloses a process for preparing sildenafil and its intermediates having the structures outlined below: ##STR00001## In particular, the...
US-8,071,764 Compounds of reverse turn mimetics and the use thereof (2)
Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and...
US-8,071,763 Methods for treatment of nocturia
A method for the treatment of nocturia which consists of administering to a mammal in need of such treatment a therapeutically effective amount of a...
US-8,071,762 Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention discloses novel compounds of general formula (I) ##STR00001## or a pharmaceutically acceptable salt or prodrug thereof (in which...
US-8,071,761 Substrates for beta-lactamase and uses thereof
Substrates for .beta.-lactamase of the general formula I ##STR00001## in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which...
US-8,071,760 Boron-containing porphyrin compounds and their uses
Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic...
US-8,071,759 Water soluble cholesterol derivatives
Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including...
US-8,071,758 Method for production of limulus-positive glycolipid, the limulus-positive glycolipid, and composition...
It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for...
US-8,071,757 Aryl/alkyl vinyl sulfone hyaluronic acid derivatives
A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural...
US-8,071,756 Polysaccharide pseudo-sponge
A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength....
US-8,071,755 Nucleotide analogs
The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
US-8,071,754 siRNA targeting apolipoprotein B (APOB)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize...
US-8,071,753 RNAi mediated expression inhibition of a cholinergic protein
The present invention relates to nucleic acid sequences producing at least one functional miRNA, at least one functional shRNA and/or at least one functional...
US-8,071,752 Multi-targeting short interfering RNAs
The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to...
US-8,071,751 Human parvovirus: bocavirus
Provided herein are sequences of the genomes and encoded proteins of a new human parvovirus, Bocavirus-2, and variants thereof. Also provided are methods of...
US-8,071,750 Determination of hepatitis C virus genotype
The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention...
US-8,071,749 Constitutive expression cassettes for regulation of plant expression
The present invention relates to expression cassettes comprising transcription regulating sequences with constitutive expression profiles in plants obtainable...
US-8,071,748 Thermophilic and thermoacidophilic sugar transporter genes and enzymes from Alicyclobacillus acidocaldarius and...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
US-8,071,747 Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such...
US-8,071,746 Isolated nucleic acid molecule encoding a peptide or peptide analog comprising the SEQ ID No. 3
Disclosed herein are peptides or peptide analogs with multiple amphipathic .alpha.-helical domains that promote lipid efflux from cells via an ABCA1-dependent...
US-8,071,745 Polynucleotides encoding rod-derived cone viability factor (rdcvf) and methods of using the same
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel...
US-8,071,744 TRP/HIS exchange and kynurenin induced TRP transport
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular...
US-8,071,743 Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors,...
US-8,071,742 Method and composition for crystallizing G protein-coupled receptors
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled...
US-8,071,741 Stable recombinant adenosine deaminase
A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized...
US-8,071,740 Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling...
US-8,071,739 Modified nucleotides
The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a...
US-8,071,738 Feline CD86 polypeptides and nucleic acids
The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4...
US-8,071,737 Nucleic acid ligand complexes
This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or...
US-8,071,736 Nucleic acid molecules encodng a cathepsin L-like cysteine protease
Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to...
US-8,071,735 Cotton event MON 88913 and compositions and methods for detection thereof
The present invention provides a cotton plant event MON 88913 compositions and seed. Also provided are assays for detecting the presence of the cotton plant...
US-8,071,734 Nucleic acid-based detection
The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a...
US-8,071,733 Antibodies that specifically bind hedgehog-derived polypeptides
The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments,...
US-8,071,732 Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias,...
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