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| Patent # | Description |
|---|---|
| US-8,071,781 |
Process for preparing rabeprazole sodium The present invention provides a process for preparing the amorphous rabeprazole sodium. The process comprises the following steps: (a) Contacting rabeprazole... |
| US-8,071,780 |
2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as
inhibitors of glucosylceramide The present invention provides novel piperidine derivatives of formula (I), ##STR00001## wherein R represents a substituted benzyl group, which are useful... |
| US-8,071,779 |
Cytoskeletal active rho kinase inhibitor compounds, composition and use The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also... |
| US-8,071,778 |
Substituted heterocyclic ethers and their use in CNS disorders The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS... |
| US-8,071,777 |
Compounds derived from artesunate, preparation process, pharmaceutical
composition and use of the respective... The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the... |
| US-8,071,776 |
Thienopyridines as allosteric potentiators of the M4 muscarinic receptor The present invention relates to selective allosteric potentiators of the Formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, for the... |
| US-8,071,775 |
Substituted rylene derivatives Rylene derivatives of the general formula I ##STR00001## in which the variables are each defined as follows: Rylene is a polycyclic conjugated ring system... |
| US-8,071,774 |
Heterocyclic spiro-compounds as aldosterone synthase inhibitors The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R.sup.1, R.sup.2, U, V, W, X, Y, Z, n and p have the... |
| US-8,071,773 |
Heterocyclic spiro-compounds as aldosterone synthase inhibitors The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R.sup.1, R.sup.2, W, X, Y, Z and n have the definitions... |
| US-8,071,772 |
Spirolactam bicyclic CGRP receptor antagonists Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,... |
| US-8,071,771 |
Bicyclic spirohydantoin CGRP receptor antagonists Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,... |
| US-8,071,770 |
Spirohydantoin aryl CGRP receptor antagonists Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, B, E.sup.1, E.sup.2, E.sup.3, E.sup.4,... |
| US-8,071,769 |
Aromatic monomer- and conjugated polymer-metal complexes A halogenated aromatic monomer-metal complex useful for preparing a polymer for electronic devices such as a light-emitting diode (LED) device is described. The... |
| US-8,071,768 |
Alkylquinoline and alkylquinazoline kinase modulators The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, B, Z, G, Q and X are... |
| US-8,071,767 |
Process for preparation of
9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one
hydrochloride Described herein is an improved, commercially viable and industrially advantageous process for the preparation of paliperidone intermediate ... |
| US-8,071,766 |
HSP90 inhibitors The invention relates to HSP90 inhibiting compounds consisting of the formula: ##STR00001## wherein the variables are as defined herein. The invention also... |
| US-8,071,765 |
Process for the preparation of sildenafil and intermediates thereof The present invention discloses a process for preparing sildenafil and its intermediates having the structures outlined below: ##STR00001## In particular, the... |
| US-8,071,764 |
Compounds of reverse turn mimetics and the use thereof (2) Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and... |
| US-8,071,763 |
Methods for treatment of nocturia A method for the treatment of nocturia which consists of administering to a mammal in need of such treatment a therapeutically effective amount of a... |
| US-8,071,762 |
Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor The present invention discloses novel compounds of general formula (I) ##STR00001## or a pharmaceutically acceptable salt or prodrug thereof (in which... |
| US-8,071,761 |
Substrates for beta-lactamase and uses thereof Substrates for .beta.-lactamase of the general formula I ##STR00001## in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which... |
| US-8,071,760 |
Boron-containing porphyrin compounds and their uses Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic... |
| US-8,071,759 |
Water soluble cholesterol derivatives Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including... |
| US-8,071,758 |
Method for production of limulus-positive glycolipid, the limulus-positive
glycolipid, and composition... It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for... |
| US-8,071,757 |
Aryl/alkyl vinyl sulfone hyaluronic acid derivatives A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural... |
| US-8,071,756 |
Polysaccharide pseudo-sponge A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength.... |
| US-8,071,755 |
Nucleotide analogs The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. |
| US-8,071,754 |
siRNA targeting apolipoprotein B (APOB) Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize... |
| US-8,071,753 |
RNAi mediated expression inhibition of a cholinergic protein The present invention relates to nucleic acid sequences producing at least one functional miRNA, at least one functional shRNA and/or at least one functional... |
| US-8,071,752 |
Multi-targeting short interfering RNAs The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to... |
| US-8,071,751 |
Human parvovirus: bocavirus Provided herein are sequences of the genomes and encoded proteins of a new human parvovirus, Bocavirus-2, and variants thereof. Also provided are methods of... |
| US-8,071,750 |
Determination of hepatitis C virus genotype The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention... |
| US-8,071,749 |
Constitutive expression cassettes for regulation of plant expression The present invention relates to expression cassettes comprising transcription regulating sequences with constitutive expression profiles in plants obtainable... |
| US-8,071,748 |
Thermophilic and thermoacidophilic sugar transporter genes and enzymes
from Alicyclobacillus acidocaldarius and... Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are... |
| US-8,071,747 |
Fusion proteins of mycobacterium tuberculosis The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such... |
| US-8,071,746 |
Isolated nucleic acid molecule encoding a peptide or peptide analog
comprising the SEQ ID No. 3 Disclosed herein are peptides or peptide analogs with multiple amphipathic .alpha.-helical domains that promote lipid efflux from cells via an ABCA1-dependent... |
| US-8,071,745 |
Polynucleotides encoding rod-derived cone viability factor (rdcvf) and
methods of using the same Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel... |
| US-8,071,744 |
TRP/HIS exchange and kynurenin induced TRP transport The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular... |
| US-8,071,743 |
Nucleic acids encoding a G-protein coupled receptor involved in sensory
transduction The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors,... |
| US-8,071,742 |
Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled... |
| US-8,071,741 |
Stable recombinant adenosine deaminase A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized... |
| US-8,071,740 |
Promoters exhibiting endothelial cell specificity and methods of using
same for regulation of angiogenesis Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling... |
| US-8,071,739 |
Modified nucleotides The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a... |
| US-8,071,738 |
Feline CD86 polypeptides and nucleic acids The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4... |
| US-8,071,737 |
Nucleic acid ligand complexes This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or... |
| US-8,071,736 |
Nucleic acid molecules encodng a cathepsin L-like cysteine protease Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to... |
| US-8,071,735 |
Cotton event MON 88913 and compositions and methods for detection thereof The present invention provides a cotton plant event MON 88913 compositions and seed. Also provided are assays for detecting the presence of the cotton plant... |
| US-8,071,734 |
Nucleic acid-based detection The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a... |
| US-8,071,733 |
Antibodies that specifically bind hedgehog-derived polypeptides The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments,... |
| US-8,071,732 |
Compositions and methods for the detection, diagnosis and therapy of
hematological malignancies Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias,... |
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