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Patent # Description
US-8,071,630 Treatment of effect of chemicals with their ultradilute stereoisomers
A method of treating an effect of a chemical agent, which agent is characterized by one or more chiral centres, by administering a dilution or an ultra-high...
US-8,071,629 2-pyridinylcycloalkylcarboxamide derivatives as fungicides
A compound of general formula (I): ##STR00001## A process for preparing this compound. A compound of general formula (II): ##STR00002## A fungicide...
US-8,071,628 Indazole derivatives
The invention is concerned with novel indazole derivatives of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y...
US-8,071,627 2-pyridinylethylcarboxamide derivatives and their use as fungicides
A compound of general formula (I) ##STR00001## A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A...
US-8,071,626 Chelating agents and highly luminescent and stable chelates and their use
This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid...
US-8,071,625 Certain chemical entities, compositions, and methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions...
US-8,071,624 N-substituted piperidines and their use as pharmaceuticals
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and...
US-8,071,623 Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are...
US-8,071,622 Indoles
The present invention is concerned with novel indol-2-yl-carbonyl-piperidin-benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a...
US-8,071,621 Alkylsulphonamide quinolines
Compounds of Formula I ##STR00001## wherein R.sup.1, A, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.8, n, m, q and r are as described in the specification,...
US-8,071,620 Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors
This invention pertains to certain carbamic acid compounds of the following formula, which inhibit HDAC (histone deacetylase) activity wherein: A is...
US-8,071,619 Injectable liquid formulation of paracetamol
The invention relates to a novel injectable liquid formulation of paracetamol, comprising an aqueous solvent, a buffer agent with a pKa between 4.5 and 6.5, an...
US-8,071,618 Caspase inhibitors and uses thereof
The present invention provides a compound of formula I: ##STR00001## wherein: X is --OR.sup.1 or --N(R.sup.5).sub.2, Y is halo, trifluorophenoxy, or...
US-8,071,617 Modulators of cellular adhesion
The present invention provides compounds having formula (I): ##STR00001## and pharmaceutically acceptable derivatives thereof, wherein R.sub.1-R.sub.4, n, p,...
US-8,071,616 Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which...
US-8,071,615 Carbonylamino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L, Q, X, Y and ...
US-8,071,614 Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors
The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R.sup.1, q, A, B, X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5...
US-8,071,613 Anti-constipation composition
An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio...
US-8,071,612 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase...
The present invention provides compounds of formula (I) and compounds of formula (VII-a) as well as pharmaceutical compositions comprising said compounds and...
US-8,071,611 Spirocyclic heterocyclic derivatives and methods of their use
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain...
US-8,071,610 Compositions and methods for enhancing brain function
Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have...
US-8,071,609 Unsaturated heterocyclic derivatives
This invention relates to compounds of the general formula: ##STR00001## in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or...
US-8,071,608 Therapeutic agents
(2S)-2-[1-(2-Chloro-6-cyano-phenyl)pyrazolo[4,5-e]pyrimidin-4-yl]oxy-3-[(- 1R)-2-hydroxy-1-methyl-ethoxy]-N-(5-methylpyrazin-2-yl)propanamide or a ...
US-8,071,607 Mnk1 or Mnk2 inhibitors
The present invention relates to the use of pyrazolopyrimidine compounds for the production of pharmaceutical compositions for the prophylaxis and/or treatment...
US-8,071,606 Substituted pyrazinone amides useful for activation of glucokinase
The present invention provides compounds of Formula (I) ##STR00001## that act as glucokinase activators; pharmaceutical compositions thereof; and methods of...
US-8,071,605 Piperidine compounds for use in the treatment of bacterial infections
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing...
US-8,071,604 Thio-substituted arylmethanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present...
US-8,071,603 Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal...
US-8,071,602 Piperidine and piperazine derivatives
Compounds of general formula (I) ##STR00001## in which R.sup.1, m, X, n, Y and R.sup.3 have any of the meanings given in the specification, have affinity for...
US-8,071,601 Aminoquinoline derivatives and their use as adenosine A3 ligands
The present invention relates to an adenosine A.sub.3 receptor ligand of the general formula (I).
US-8,071,600 Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders
A heterocyclic compound or a salt thereof represented by the formula (1): where R.sup.2 represents a hydrogen atom or a lower alkyl group; A represents a lower...
US-8,071,599 Methods of treatment of chronic pain using eszopiclone
The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain.
US-8,071,598 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and...
US-8,071,597 Pyrazine compounds and uses as PI3K inhibitors
The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or...
US-8,071,596 Endothelin receptor antagonists
This invention relates to novel endothelin receptor antagonists, derivatives, acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The...
US-8,071,595 1,2-disubstituted heterocyclic compounds
1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions,...
US-8,071,594 Substituted diketopiperazines and their use as oxytocin antagonists
Compounds of formula (1) ##STR00001## wherein R.sub.1 is 2-indanyl, R.sub.2 is 1-methylpropyl, R.sub.3 is 2-methyl-1,3-oxazol-4-yl and R.sub.4 and R.sub.5...
US-8,071,593 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of...
Described are compounds which inhibit, regulate and/or modulate kinase signal transduction, for example of Met kinase. The compounds are of the formulae A1 to...
US-8,071,592 Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
Bicyclic nitrogen containing compounds and their use as antibacterials.
US-8,071,591 7-cycloalkylaminoquinolones as GSK-3 inhibitors
Provided herein are aminoquinolones of formula I and compositions containing the compounds, wherein formula I is ##STR00001## The compounds and compositions...
US-8,071,590 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as...
A subject of the invention is the compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R.sub.6 and...
US-8,071,589 Dihydrobenzoindazoles
The invention relates to benzoindazole derivatives according to general Formula I ##STR00001## or a pharmaceutically acceptable salt thereof. The compounds...
US-8,071,588 Dual pharmacophores--PDE4-muscarinic antagonistics
The present invention relates to novel compounds of Formula (I) ##STR00001## and their use in the treatment of respiratory diseases, including...
US-8,071,587 (Dihydro)imidazoiso[5,1-A]quinolines
The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I ##STR00001## or a...
US-8,071,586 Heterocyclyl compounds
The invention is concerned with novel heterocyclyl compounds of formula (I) ##STR00001## wherein A, X, Y.sup.1, Y.sup.2, Y.sup.3, R.sup.3, R.sup.4, R.sup.5,...
US-8,071,585 Therapeutic agents
A compound (2S)-2-[1-(2,6-dichlorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]oxy-3-(3-hydr- oxyazetidin-1-yl)-N-(5-methylpyrazin-2-yl)propanamide is useful in the ...
US-8,071,584 Indole carboxamides as IKK2 inhibitors
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): ##STR00001## ...
US-8,071,583 Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus
The present invention relates to substituted pyrrolo[3,2-d]pyrimidines of formula (I), wherein R1 and R2 are defined as in claim 1, including the tautomers,...
US-8,071,582 Substituted aniline derivatives
The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.
US-8,071,581 Triazolopyridazine protein kinase modulators
The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by...
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