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Medium-chain length fatty alcohols as stimulators of hematopoiesis
Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem...
DNA damage repair inhibitors for the treatment of cancer
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR...
Tazarotene and corticosteroid treatment for psoriasis
The present invention provides a method for treating proliferative skin diseases comprising the administration of an effective amount of tazarotene and an...
Multi-phase contraceptive preparation based on a natural estrogen
The multiphase preparation having higher contraceptive safety and reduced side effects is based on a combination of a natural oestrogen with dienogest or...
Method of preventing or treating benign gynaecological disorders
The present invention relates to a method of preventing or treating benign estrogen sensitive gynecological disorders in a female mammal, wherein the method...
Methods and compounds for the targeted delivery of agents to bone for
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (R.sub.T), having an affinity for bone; a Bone Active Portion...
Implant improving local bone formation
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a...
Bisphosphonate compounds and methods for bone resorption diseases, cancer,
bone pain, immune disorders, and...
Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity...
Preventive/remedy for obesity
The present invention relates to a preventive/remedy for obesity, which has a hydroxypropylated starch as its active ingredient. Provided are materials for...
A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
Mixtures of polysaccharides derived from heparin, their preparation and
pharmaceutical compositions containing them
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa...
Oxidized heparin fractions and their use in inhibiting angiogenesis
The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from...
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA
The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral...
4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication
The present invention relates to the use of nucleoside derivatives of formula Ia ##STR00001## wherein the symbols are as defined in the specification, and of...
Methods of coronary imaging
The present invention provides methods of myocardial perfusion imaging and increasing coronary blood flow of a mammal that are accomplished by administering...
Purine derivatives as a2a agonists
Compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, R.sup.1, R.sup.2 and R.sup.3 have the meanings as indicated...
Regulation of angiogenesis with zinc finger proteins
Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications...
Glutamic acid decarboxylase (GAD) chimera and methods of use
The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the...
MiR-124 regulated genes and pathways as targets for therapeutic
The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-124, using miR-124 to modulate a gene or gene...
Aspects of the present invention relate to chimeric polypeptides including HCV NS3/4A sequences and T-cell epitopes. Embodiments include nucleic acids encoding...
Materials and methods for reducing inflammation by inhibition of the
atrial natriuretic peptide receptor
This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the...
Compositions and methods for cancer diagnosis and treatment
The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans,...
Application of D-psicose to suppression of abnormal circadian increase in
blood glucose level
A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active...
Treatment of pulmonary hypertension with carbonic anhydrase inhibitors
This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the...
Peptide substance revealing a stress protective effect, pharmaceutical
composition on its base, and the method...
Disclosed is a peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence 1 [SEQ ID NO:1], having a stress protective effect. Also...
Protective skin care peptides
The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or...
Tissue protective peptides and uses thereof
The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor...
Method and peptide for regulating cellular activity
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular...
Peptides and peptidomimetics binding to CD23
The present invention describes compounds comprising new and useful peptides and peptidomimetics that can bind to CD23. They are capable of reducing...
Methods and compositions for treating diabetes
The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically...
Methods for treating uterine disorders
A method for treating uterine disorders, including hyperplasic, hypertonic, cystic and/or neoplastic uterine gland tissue by local administration of a botulinum...
Compounds capable of affecting differentiation, proliferation,
regeneration, plasticity and survival cells
The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth...
Method of reducing injury to mammalian cells
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to...
Compositions of alpha-fetoprotein and inducers of apoptosis for the
treatment of cancer
The invention relates to novel compositions comprising alpha-fetoprotein (AFP) and methods for preventing, treating or inhibiting a malignant neoplasm...
Uses of pegylated albumin
The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume,...
Therapies and compositions for controlling the stress mechanism and for
stabilizing hemostasis in an organism
A method for treating skin malignancies, malignant tumors, metastatic malignancies and abnormal skin growths in an organism by treating the organism to inhibit...
Crystallized recombinant human growth factor formulations
Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins.
Methods of treating neurological conditions with hematopoeitic growth
The present invention relates to a method of treating a neurological condition in a mammal by administering at least one hematopoietic growth factor.
Use of ferritin to treat iron deficiency disorders
The present inventors have demonstrated the presence of H-ferritin receptors on endothelial cells in culture and on rat brain rat brain microvasculature,...
Methods for preparing internally constrained peptides and peptidomimetics
The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3.sub.10-helical,...
Virus derived antimicrobial peptides
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of...
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by...
Method of increasing muscle mass by administering a myostatin binding
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent...
Implantable device for the sustained release of a polypeptide
Described herein are implantable devices, formulations and methods of making implantable devices for the release of a polypeptide from an implantable device,...
Mutant DNA polymerases with improved pyrophosphorolysis activated
polymerization (PAP) ability
Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a...
Guanidinium derivatives for improved cellular transport
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the...
Material for facilitating thermal treatments of biological tissues and
method of energy targeting leading to...
A method includes positioning an effective amount of a thermal target material at a treatment site of a patient. The treatment site, that is, the location of...
Compositions and methods for modulating store-operated calcium entry
Compositions and methods for modulating activity of store-operated calcium entry in cells or tissues are provided. The compositions comprise the P311 protein,...
Use of C1 inhibitor for the prevention of ischemia-reperfusion injury
The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The...
Flavor and fragrance composition
A flavor and fragrance composition with a cooling sensation effect comprising 1-(2-hydroxy-4-methylcyclohexyl)ethanone represented by the formula (1). The...