The present invention intends to provide a solid preparation which contains an insulin sensitizer and an active ingredient other than an insulin sensitizer, and...
Disclosed are novel pharmaceutical compositions containing 3'-[(2Z)-[1-(3,4-dimethylphenyl) ...
Intrabuccally rapidly disintegrating tablet and a production method of the
An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the...
Dual action, inhaled formulations providing both an immediate and
sustained release profile
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical...
Percutaneous absorption type patch
A percutaneous absorption type patch adapted to be applied to a skin surface of a patient. The percutaneous absorption type patch comprises: a stratum-corneum...
Transdermal patch containing isosorbide dinitrate and bisoprolol
This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically...
Methods of using expandable foam-like biomaterials
Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like...
Process for producing edible orally administered agent of laminate film
form and compression bonding apparatus
Two resin films each provided with an orally administrable edible agent layer are joined so that administrable agent layers face each other, drawn into a nip...
Compositions and methods for increasing lean muscle mass and/or reducing
Compositions and methods for increasing lean muscle mass and/or reducing fat gain in growing animals by feeding the animals a composition having a total lysine...
Dispersions of microemulsions in hydrogels for drug delivery
An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically...
Methods for treating neovascularization and intravitreal implants
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and...
Controlled release implantable dispensing device and method
A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is "hyper-compressed" to...
Method of inducing cell proliferation using fibroin
A bioactive material is made using fibroin solutions and suspensions designed to support the constructions, repair, regeneration or augmentation of bone and...
The apple leaf midge and raspberry cane midge pheromones have been found to be acetoxyheptadecenone and acetoxyundecanone, respectively, and uses for these and...
Combination product for controlling parasites on animals
The invention relates to novel compositions for controlling parasites on animals, comprising an N-arylpyrazole and also a pyrethroid in a formulation comprising...
Cosmetics containing an active component comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria; a skin...
Compositions containing quaternary ammonium compounds
This invention relates to compositions containing quaternary ammonium compounds in which the nitrogen atom is substituted by at least one alkyl group having at...
Live, oral vaccine for protection against Shigella dysenteriae serotype 1
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O...
Compositions and methods of use of ORF-1358 from beta-hemolytic
The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also...
Virulence of Streptococci
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci....
Activatable clostridial toxins
Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such...
VMP-like sequences of pathogenic Borrelia
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to...
Pestivirus mutant for use in a vaccine
The present invention comprises new pestivirus mutants, characterized in that the mutants are based on a cp strain of the virus wherein part of the gene...
Nucleic acids encoding modified human immunodeficiency virus type 1
(HIV-1) group M consensus envelope...
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV...
Topical formulation containing latex of fraction thereof, and cosmetic
The present invention refers to a topical formulation containing natural latex or fraction thereof, for topical application, aiming to provide skin...
Reishi F3 sub fraction polysaccharides and methods of using same
The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to...
Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and...
Pharmaceutical composition comprising a human GLP-1 mimetibody
The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at...
Methods to clear meningitis causing agents using antibodies to peptides
representing epitopic sites for...
Novel vaccines include polypeptides that comprise regions corresponding to a chemokine and a hapten. The hapten can be an amino acid sequence corresponding to...
Antibody therapy for treatment of diseases associated with gluten
The present invention includes a pharmaceutical compositions and methods for treating diseases associated with gluten intolerance in a patient, comprising:...
Monoclonal antibodies that neutralize anthrax toxins
The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA)....
The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention...
Method of preventing cerebral vasospasm with anti-HMGB1 antibody
An objective of the present invention is to provide a cerebral vasospasm inhibitor which is effective on cerebral vasospasm occurring after subarachnoid...
Apoptotic anti-IgE antibodies
The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the...
Anti-C5aR antibodies and uses thereof
The present invention relates to antibodies which bind to C5aR and which are useful in diagnostic and therapeutic methods. The antibodies of the present...
Immunosuppressive polypeptides and nucleic acids
The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4...
Anti-idiotypic antibody neutralizing the inhibitor activity of a factor
VIII inhibitor antibody
The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the domain A2 of Factor...
Fully human anti-epidermal growth factor receptor antibodies
Disclosed are fully human anti-epidermal growth factor receptor (EGFR) antibodies, fragments thereof, and nucleic acid sequences encoding for the same. Further...
Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which...
Non-neurotoxic plasminogen activating factors for treating stroke
The invention pertains to the use and production of non-neurotoxic plasminogen activating factors e.g. of Desmodus rotundus (DSPA) for the therapeutic treatment...
Stabilized thrombin compositions
Stabilized thrombin compositions, processes for preparing them, and kits comprising them are disclosed. The compositions comprise thrombin, a bacteriostatically...
Composition with a fungal (yeast) lipase and method for treating lipid
malabsorption in cystic fibrosis as well...
The invention provides compositions and methods for treating pancreatic enzyme insufficiency, such as the pancreatic enzyme insufficiency associated with cystic...
Compositions and methods for reducing the pathogen content of meat and
Compositions and methods useful for reducing or eliminating the presence of pathogens in meat and meat products are disclosed. Administration of one or more...
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so...
Bacterial composition and its use
The subject of the present invention is a bacterial composition having immunomodulation properties comprising at least one strain selected from the group...
Primary cultured adipocytes for gene therapy
The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is...
Vaccine for protection against Shigella sonnei disease
Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for...
The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded...
End-modified poly(beta-amino esters) and uses thereof
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is...
Reduction of airborne malodors using hydrogen peroxide and a
Compositions, methods and apparatuses for reducing or eliminating malodors from indoor air are described. The method utilizes vapor phase hydrogen peroxide...