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Patent # Description
US-8,076,329 Histamine H3-receptor ligands and their therapeutic applications
The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or...
US-8,076,328 Use of fungicides for the treatment of fish mycoses
Process for the protection of fish and invertebrates and all their stages of development against or for the treatment of mycoses caused by fungi of the genera...
US-8,076,327 Condensed imidazole derivatives as aldosterone synthase inhibitors
The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferable pharmaceutically acceptable salts, thereof, in which R,...
US-8,076,326 N-phenyl- (piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenl-(piperazine or...
The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine)...
US-8,076,325 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions...
Compounds of formula (I): ##STR00001## wherein: R.sub.1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted...
US-8,076,324 Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, ##STR00001## in which Ar.sup.1, Ar.sup.2, R.sup.1 and R.sup.2 have...
US-8,076,323 Anti-inflammatory agents
The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a...
US-8,076,322 [6,6] and [6,7]-bicyclic GPR119 G protein-coupled receptor agonists
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating,...
US-8,076,321 Compositions for treatment of systemic mastocytosis
The present invention relates to the use of the combination of tyrosine phosphate inhibitors AMN107 and PKC412 for the preparation of a drug for the treatment...
US-8,076,320 Crystalline forms of a pharmaceutical compound
Described are crystalline forms of the pharmaceutical compound "[9S-(9.alpha.,10.beta.,12.alpha.)]-5,16-Bis[(ethylthio)methyl]-2,3,9,10,- ...
US-8,076,319 Treatment of conditions relating to hormone deficiencies by administration of progestins
The present invention includes methods for preventing endometrial hyperplasia associated with estrogen therapy through the administration of a progestin agent....
US-8,076,318 Caged ligands and uses thereof
Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand...
US-8,076,317 Contraception process and administration form for the same
Process for hormonal contraception, in which in a plurality of substantially time-unlimited, linked taking periods and optionally having a sequence lasting...
US-8,076,316 Steroid compounds and formulations
The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for...
US-8,076,315 Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists
This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need...
US-8,076,314 Topical compositions for anti-aging and methods of using same
A pharmaceutical composition for treatment of skin aging including a pharmaceutically effective amount of estriol; a pharmaceutically effective amount of...
US-8,076,313 Composition containing fermentable polysaccharides
The present invention relates to a composition to a nutritional composition comprising 0.1 to 15 gram fermentable e partially hydrolysed gum having a degree of...
US-8,076,312 Use of lipid conjugates in the treatment of disease
This invention provides a method of preventing asthma, allergic rhinitis, or chronic obstructive pulmonary disease in a subject comprising the step of...
US-8,076,311 Compositions and methods for modulating the immune system
The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and...
US-8,076,310 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral...
Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted...
US-8,076,309 USP47 inhibtors and methods to induce apoptosis
The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain...
US-8,076,308 Inhibition of autophagy genes in cancer chemotherapy
There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or...
US-8,076,307 Formation/elongation of axon by inhibiting the expression or function of Singar and application to nerve...
Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating...
US-8,076,306 Compositions and their uses directed to hepcidin
Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or...
US-8,076,305 Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated...
US-8,076,304 Methods and compositions for the diagnosis and treatment of cyclin A-1 associated conditions
The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for...
US-8,076,303 Nucleotide and oligonucleotide prodrugs
The present invention discloses compounds of formula (I): ##STR00001## which exhibit antiviral properties. The present invention further relates to...
US-8,076,302 Pyrimidine nucleoside derivatives and salts thereof
A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the...
US-8,076,301 10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment...
US-8,076,300 FGF2-binding peptides and uses thereof
FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region....
US-8,076,299 Method for producing peptide thioester
It is an object of the present invention to provide a novel method for producing a peptide thioester. In the present invention, general peptide synthesis is...
US-8,076,298 Treating acute renal failure with soluble thrombomodulin variants
The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises...
US-8,076,297 Pharmaceutical composition containing polypeptide fragments of serralysins
The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated...
US-8,076,296 Cosmetic compositions
A topical composition having (i) an isolated polypeptide having the sequence of SEQ ID NO: 1 or a functional equivalent thereof, and (ii) a cosmetically...
US-8,076,295 Peptide amphiphiles having improved solubility and methods of using same
Disclosed herein are novel peptide amphiphile molecules and compositions discovered to possess improved solubility in aqueous buffers which, in turn,...
US-8,076,294 Collagen-related peptides and uses thereof
The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent...
US-8,076,293 Use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the...
The present invention relates to the use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the prevention or...
US-8,076,292 Factor VIII: remodeling and glycoconjugation of factor VIII
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a...
US-8,076,291 Treatment for obesity
The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin...
US-8,076,290 Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,...
US-8,076,289 Fibrosis inhibitor for implanted organ
A pharmaceutical preparation comprising a hepatocyte growth factor or a DNA molecule encoding the same and the like according to the present invention can...
US-8,076,288 Hybrid polypeptides having glucose lowering activity
The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and...
US-8,076,287 Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals
The present invention provides cyclic hexadepsipeptides and their pharmaceutically acceptable salts, solvates and prodrugs, and methods for obtaining the...
US-8,076,286 Antimicrobial peptides and use thereof
The invention relates to a molecule comprising at least the amino acid sequence X.sub.1 X.sub.2 X.sub.3 X.sub.4 X.sub.5 X.sub.6 W X.sub.8 X.sub.9 X.sub.10...
US-8,076,285 Lysobactin amides
The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or...
US-8,076,284 Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5
Antimicrobial and anticancer peptides engineered using Gaegurin 5 isolated from Korean frog (Rana rugosa), which have a smaller structure compared with...
US-8,076,283 Methods for treating congestive heart failure
The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like...
US-8,076,282 Composition for improving membrane composition and functioning of cells
It has now been found that after administration to a diseased person or person that is at risk for developing such disease of a neutraceutical or pharmaceutical...
US-8,076,281 Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by...
US-8,076,280 Emulsions containing encapsulated fragrances and personal care compositions comprising said emulsions
The present invention provides an emulsion comprising an organic discontinuous phase which is distributed throughout a continuous aqueous phase, wherein the...
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