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Patent # Description
US-8,084,625 Crosslinking agent, crosslinking method, method of controlling gene expression, and method of examining gene...
The present invention provides a crosslinking agent which have photodegradable protective groups at two ends to crosslink double-stranded nucleic acid, a...
US-8,084,624 Condensed polycyclic aromatic compound and use thereof
The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of...
US-8,084,623 Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof
Compounds of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R.sup.1, R.sup.2, R.sup.a and R.sup.b are defined...
US-8,084,622 Process for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof
An industrially advantageous process for the production of (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine or an enantiomer thereof that is useful as an...
US-8,084,621 3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof
3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of...
US-8,084,620 Carbazole carboxamide compounds useful as kinase inhibitors
Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, ##STR00001## are useful as kinase...
US-8,084,619 Gas generant compositions
A novel compound, used for example, as a gas generating fuel, is defined as a compound having the structural formula of R.sub.3--R.sub.1--R.sub.2, wherein R1 is...
US-8,084,618 Heterocyclic compounds and methods of use
Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic...
US-8,084,617 Ionic liquids having fluoroalkyltrifluoroborate anions
The invention relates to compounds of the formula (I), in which X, -Q.sup.1-Q.sup.2- and R.sup.F have the meaning indicated in Claim 1, as ionic liquids, and to...
US-8,084,616 TRPV1 antagonists
The present invention relates to compounds of formula (I) ##STR00001## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, m, and n are defined in the...
US-8,084,615 Antibacterial agents
Antibacterial compounds of formula I are provided: ##STR00001## As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof;...
US-8,084,614 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds...
US-8,084,613 Tetrazoyloxime derivative and plant disease control agent
The present invention provides a tetrazoyloxime derivative or salt thereof, represented by the following formula (1): ##STR00001## [wherein, R.sup.1 represents...
US-8,084,612 Proline analogs as ligands for cannabinoid receptors
The invention relates to compounds of Formulae I(a) to XI ##STR00001## ##STR00002## ##STR00003## ##STR00004## and pharmaceutically acceptable salts and...
US-8,084,611 Process for preparing tetrahydroquinoline derivatives
The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or...
US-8,084,610 Compositions and methods for detecting and treating tumors containing acidic areas
Improved compositions have been developed which are selectively sequestered in acidic areas of tumors. When the compositions contain a radioisotope effective to...
US-8,084,609 Spiropiperidine derivatives
The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions...
US-8,084,608 2,2' -bipyridine derivative having a reactive silyl group, its production method, and transition metal complex
A 2,2'-bipyridine derivative having a reactive silyl group represented by the following general formula (1): ##STR00001## wherein R.sup.1 and R.sup.2...
US-8,084,607 Apoptosis promoters
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for...
US-8,084,606 Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of...
The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of...
US-8,084,605 Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin- ...
Compositions comprising the succinate salt of 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin- -1-ylmethyl]-4-fluoro-benzonitrile...
US-8,084,604 Process for the preparation of dihydroquinazolines
The present invention relates to a process for the preparation of dihydroquinazolines, for example ...
US-8,084,603 Naphthalenetetracarboxylic acid derivatives and their use as semiconductors
The present invention relates to naphthalenetetracarboxylic acid derivates, to a process for their preparation and to their use, especially as an n-type...
US-8,084,602 Porphyrin derivatives and their use in photodynamic therapy
A compound of formula I: ##STR00001## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4 and Z have meanings given in the...
US-8,084,601 Oligomers
Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be...
US-8,084,600 Short interfering ribonucleic acid (siRNA) with improved pharmacological properties
Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at...
US-8,084,599 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as...
US-8,084,598 Bioionformality detectable group of novel regulatory oligonucleotides and uses thereof
The present invention relates to a first group of novel oligonucleotides, here identified as genomic address messenger or GAM oligonucleotides, and a second...
US-8,084,597 Artificial entropic bristle domain sequences and their use in recombinant protein production
Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides,...
US-8,084,596 Regulated apoptosis
We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials...
US-8,084,595 Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as...
US-8,084,594 H2N3 influenza A viruses and methods of use
The present invention provides influenza A viruses that include a hemagglutinin subtype H2, a neuraminidase subtype N3, or the combination thereof. Included in...
US-8,084,593 Polynucleotide encoding a TRIM-Cyp polypeptide, compositions thereof, and methods of using same
The invention provides an isolated nucleic acid encoding a TRIM--cyclophilin A fusion sequence encoding a TRIMcyp fusion protein which is active as an...
US-8,084,592 Multivalent entrain-and-amplify immunotherapeutics for carcinoma
The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic...
US-8,084,591 Factor VII or VIIA-like molecules
Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing...
US-8,084,590 Labelled nucleotides
The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable...
US-8,084,589 Phosphoramidite nucleoside analogs
Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be...
US-8,084,588 Fluorescence quenching azo dyes, their methods of preparation and use
Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the...
US-8,084,587 Method for the production of proteins
The present invention relates to a process for the purification of a protease.
US-8,084,586 Doxorubicin immunoassay
Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these...
US-8,084,585 Anti-ILT7 antibody
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The...
US-8,084,584 Methods for stabilizing proteins
The present inventors revealed that deamidation of an antibody can be suppressed without influencing its activity by substituting a glycine that is located...
US-8,084,583 RS7 antibodies
This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these...
US-8,084,582 Optimized anti-CD20 monoclonal antibodies having Fc variants
The present invention relates to optimized CD20 antibodies having Fc variants, methods for their generation, and method for their application, such as methods...
US-8,084,581 Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin...
A method heat treatment of cross-linked hemoglobin solutions including polymeric hemoglobin is disclosed. The method involves contacting the hemoglobin solution...
US-8,084,580 Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them
The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterized in...
US-8,084,579 Composition comprising a purified collagen-like polypeptide suitable as a peptizer
A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y] repeats, wherein Gly stands for...
US-8,084,578 Monoclonal antibody against human scavenger receptor SRCL-P1
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of...
US-8,084,577 Crystal of human glycoprotein VI collagen binding domain
A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on...
US-8,084,576 Cancer associated glucose transporter 8 variant
The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific...
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