Pirfenidone therapy and inducers of cytochrome P450
The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
Compounds of formula (I) wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric...
Heterocyclic compounds with affinity to muscarinic receptors
The present invention relates to heterocyclic compounds of the formula (I) ##STR00001## or a pharmaceutically acceptable salt, a solvate or hydrate thereof.
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases...
Proteomimetic compounds as inhibitors of the interaction of nuclear
receptor with coactivator peptides
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors,...
Substituted nicotinamide compounds and uses thereof
Substituted nicotinamide compounds corresponding to formula I ##STR00001## a process for their preparation, pharmaceutical compositions containing these...
The invention relates to compounds of the formula (I) ##STR00001## to processes for the preparation thereof, and to the use thereof for the treatment of...
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein R.sup.1, R.sup.2, A, G,...
Pyrazole derivatives as cannabinoid receptor antagonists
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole...
Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine
Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H.sub.4 receptor modulators. Such compounds may be used in pharmaceutical...
Derivatives of pryidone and use thereof
The present invention provides N-substituted-2(1H) pyridones or the pharmaceutical acceptable salts thereof, and the pharmaceutical preparations containing the...
This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides...
Quinuclidine derivatives and their use as muscarinic M3 receptor
Compounds of Formula (I); in salt or zwitterionic form wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings as indicated in the specification, are...
3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
The present invention relates to the pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs),...
Albuterol and ipratropium inhalation solution, system, kit and method for
relieving symptoms of chronic...
The present invention relates to a dual bronchodilator inhalation solution, system, kit and method for relieving bronchospasm in patients suffering from chronic...
6,7-unsaturated-7-carbamoyl substituted morphinan derivative
A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): ...
Substituted quinazolinones for treating neurological conditions
Compounds of the formula ##STR00001## or salts, tautomers or isomers thereof, are useful for treating neurological conditions, especially neurodegenerative...
Synthesis of locked nucleic acid derivatives
Methods are described for the synthesis of Locked Nucleic Acid (LNA) derivatives using certain nitrogen-containing nucleophiles.
Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as
modulators of protein kinases
The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as...
Pyrazine-based tubulin inhibitors
A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A...
Use of a kinase inhibitor for the treatment of particular resistant tumors
The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine...
Compounds with anti-cancer activity
Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or...
Alkyl substituted indoloquinoxalines
Novel substituted indoloquinoxalines of formula (I ##STR00001## wherein R.sup.1 is hydrogen or represents one or more similar or different substituents in...
Substituted enaminocarbonyl compounds used as insecticides
The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal...
Heteropyrrole analogs acting on cannabinoid receptors
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the...
3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment...
Dual pharmacophores--PDE4-muscarinic antagonistics
The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, ##STR00001## pharmaceutical compositions and...
Compounds of the formula ##STR00001## are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions...
Pharmaceutical composition comprising gabapentin or an analogue thereof
and an .alpha.-aminoamide and its...
There is disclosed a pharmaceutical composition comprising gabapentin or an analogue thereof (pregabalin or tiagabine) and an .alpha.-aminoamide and its...
Use of DHEA derivatives for enhancing physical performance
A method is disclosed for administering a DHEA derivative or a physiologically acceptable salt, ester or ether thereof for one of decreasing body weight,...
Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a...
Treatment of dermatitis with dehydroepiandrosterone-glucocorticoid
Dermatitis can be effectively treated with the combined administration of dehydroepiandrosterone (DHEA) and a glucocorticoid. Systemic, topical and prepackaged...
Biological specimen collection and transport system and methods of use
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using...
N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake
The present invention provides a pyrrolidine compound of General Formula (1) ##STR00001## or a salt thereof, wherein R.sup.101 and R.sup.102 are each...
Cystitis treatment with high dose chondroitin sulfate
Interstitial cystitis and related GAG-deficient conditions of the bladder and urinary tract are treated by instillation of high dose chondroitin sulfate, such...
Method for improving the fertility of animals
This invention is in the field of animal food, in particular food for female animals in their reproductive phase. Food according to the invention improves the...
Methods for identifying compounds for the treatment of type 1 diabetes
The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes and also provides methods for treating patients...
Compositions and methods of sphingosine kinase inhibitors in radiation
therapy of various cancers
The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and...
Methods for treating hypercholesterolemia
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds...
Modulation of SGLT2 expression
Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid...
Biodegradable linkers for molecular therapies
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable...
Runx2 isoforms in angiogenesis
The present invention relates to RUNX2 and RUNXdelta8, and their use in modulating conditions and diseases associated with angiogenesis and cell proliferation....
Antisense antiviral compound and method for treating ssRNA viral infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae,...
Compositions and methods for treatment of pouchitis
The present invention relates methods of treating pouchitis by administering a pharmaceutical formulation suitable for rectal use, such as an enema or...
Method for inhibiting activation of macrophages, inhibiting formation of
osteoclasts, inhibiting function of...
A method for inhibiting the activation of macrophages, inhibiting the formation of osteoclasts, inhibiting the function of osteoclasts, and/or activating...
ENT-kaurene diterpene compound and its derivatives, their preparation and
Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used...
Compounds and their analgesic applications
Provided are compounds represented by: ##STR00001## wherein R.sub.1 is a D-alanine, D-serine, D-threonine, D-methionine, D-leucine, D-asparagine or...
Method of repairing meniscal tears
A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face...
Subcutaneous implants containing a degradation-resistant polylactide
The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a ...
Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method
FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is...