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Patent # Description
US-8,084,475 Pirfenidone therapy and inducers of cytochrome P450
The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
US-8,084,474 Insecticides
Compounds of formula (I) wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric...
US-8,084,473 Heterocyclic compounds with affinity to muscarinic receptors
The present invention relates to heterocyclic compounds of the formula (I) ##STR00001## or a pharmaceutically acceptable salt, a solvate or hydrate thereof.
US-8,084,472 Fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases...
US-8,084,471 Proteomimetic compounds as inhibitors of the interaction of nuclear receptor with coactivator peptides
The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors,...
US-8,084,470 Substituted nicotinamide compounds and uses thereof
Substituted nicotinamide compounds corresponding to formula I ##STR00001## a process for their preparation, pharmaceutical compositions containing these...
US-8,084,469 Substituted piperidines
The invention relates to compounds of the formula (I) ##STR00001## to processes for the preparation thereof, and to the use thereof for the treatment of...
US-8,084,468 Fungicidal amides
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein R.sup.1, R.sup.2, A, G,...
US-8,084,467 Pyrazole derivatives as cannabinoid receptor antagonists
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole...
US-8,084,466 Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H.sub.4 receptor
Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H.sub.4 receptor modulators. Such compounds may be used in pharmaceutical...
US-8,084,465 Derivatives of pryidone and use thereof
The present invention provides N-substituted-2(1H) pyridones or the pharmaceutical acceptable salts thereof, and the pharmaceutical preparations containing the...
US-8,084,464 Tetrahydroisoquinoline derivatives
This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides...
US-8,084,463 Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists
Compounds of Formula (I); in salt or zwitterionic form wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings as indicated in the specification, are...
US-8,084,462 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
The present invention relates to the pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs),...
US-8,084,461 Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic...
The present invention relates to a dual bronchodilator inhalation solution, system, kit and method for relieving bronchospasm in patients suffering from chronic...
US-8,084,460 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): ...
US-8,084,459 Substituted quinazolinones for treating neurological conditions
Compounds of the formula ##STR00001## or salts, tautomers or isomers thereof, are useful for treating neurological conditions, especially neurodegenerative...
US-8,084,458 Synthesis of locked nucleic acid derivatives
Methods are described for the synthesis of Locked Nucleic Acid (LNA) derivatives using certain nitrogen-containing nucleophiles.
US-8,084,457 Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as...
US-8,084,456 Pyrazine-based tubulin inhibitors
A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A...
US-8,084,455 Use of a kinase inhibitor for the treatment of particular resistant tumors
The invention provides low molecular weight compounds, namely tetrahydropyrrolo[3,4-c]pyrazoles, showing a high affinity for the ATP pocket of ABL tyrosine...
US-8,084,454 Compounds with anti-cancer activity
Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or...
US-8,084,453 Alkyl substituted indoloquinoxalines
Novel substituted indoloquinoxalines of formula (I ##STR00001## wherein R.sup.1 is hydrogen or represents one or more similar or different substituents in...
US-8,084,452 Substituted enaminocarbonyl compounds used as insecticides
The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal...
US-8,084,451 Heteropyrrole analogs acting on cannabinoid receptors
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the...
US-8,084,450 Organic compounds
3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment...
US-8,084,449 Dual pharmacophores--PDE4-muscarinic antagonistics
The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, ##STR00001## pharmaceutical compositions and...
US-8,084,448 Organic compounds
Compounds of the formula ##STR00001## are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions...
US-8,084,447 Pharmaceutical composition comprising gabapentin or an analogue thereof and an .alpha.-aminoamide and its...
There is disclosed a pharmaceutical composition comprising gabapentin or an analogue thereof (pregabalin or tiagabine) and an .alpha.-aminoamide and its...
US-8,084,446 Use of DHEA derivatives for enhancing physical performance
A method is disclosed for administering a DHEA derivative or a physiologically acceptable salt, ester or ether thereof for one of decreasing body weight,...
US-8,084,445 Pharmaceutical formulation
Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a...
US-8,084,444 Treatment of dermatitis with dehydroepiandrosterone-glucocorticoid combinations
Dermatitis can be effectively treated with the combined administration of dehydroepiandrosterone (DHEA) and a glucocorticoid. Systemic, topical and prepackaged...
US-8,084,443 Biological specimen collection and transport system and methods of use
Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using...
US-8,084,442 N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
The present invention provides a pyrrolidine compound of General Formula (1) ##STR00001## or a salt thereof, wherein R.sup.101 and R.sup.102 are each...
US-8,084,441 Cystitis treatment with high dose chondroitin sulfate
Interstitial cystitis and related GAG-deficient conditions of the bladder and urinary tract are treated by instillation of high dose chondroitin sulfate, such...
US-8,084,440 Method for improving the fertility of animals
This invention is in the field of animal food, in particular food for female animals in their reproductive phase. Food according to the invention improves the...
US-8,084,439 Methods for identifying compounds for the treatment of type 1 diabetes
The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes and also provides methods for treating patients...
US-8,084,438 Compositions and methods of sphingosine kinase inhibitors in radiation therapy of various cancers
The present invention relates to Sphingosine kinase inhibitors that are useful for treating various cancers. The invention further relates to compositions and...
US-8,084,437 Methods for treating hypercholesterolemia
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds...
US-8,084,436 Modulation of SGLT2 expression
Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid...
US-8,084,435 Biodegradable linkers for molecular therapies
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable...
US-8,084,434 Runx2 isoforms in angiogenesis
The present invention relates to RUNX2 and RUNXdelta8, and their use in modulating conditions and diseases associated with angiogenesis and cell proliferation....
US-8,084,433 Antisense antiviral compound and method for treating ssRNA viral infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae,...
US-8,084,432 Compositions and methods for treatment of pouchitis
The present invention relates methods of treating pouchitis by administering a pharmaceutical formulation suitable for rectal use, such as an enema or...
US-8,084,431 Method for inhibiting activation of macrophages, inhibiting formation of osteoclasts, inhibiting function of...
A method for inhibiting the activation of macrophages, inhibiting the formation of osteoclasts, inhibiting the function of osteoclasts, and/or activating...
US-8,084,430 ENT-kaurene diterpene compound and its derivatives, their preparation and their use
Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used...
US-8,084,429 Compounds and their analgesic applications
Provided are compounds represented by: ##STR00001## wherein R.sub.1 is a D-alanine, D-serine, D-threonine, D-methionine, D-leucine, D-asparagine or...
US-8,084,428 Method of repairing meniscal tears
A method of repairing a meniscal tear of a subject includes providing a sheet of collagen membrane material having on one side thereof a smooth barrier face...
US-8,084,427 Subcutaneous implants containing a degradation-resistant polylactide polymer
The present invention refers to compositions comprising a LH-RH-analogue and/or pharmaceutically acceptable salts thereof in a low-dose and a ...
US-8,084,426 Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
FGF18 is known to stimulate the proliferation of chondrocytes, bone, and nervous tissue, resulting in repair of diseased tissue. When an IL-1 antagonist is...
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