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Preparation of protective antigen
A polynucleotide sequence is provided comprising a nucleic acid sequence encoding recombinant Protective Antigen (rPA). Also provided are expression vectors and...
Ghrelin binding nucleic acids
The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises a first stretch Box A, and a second...
Methods of evaluating mixtures of polysaccharides
Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of...
Methods of producing validamycin A analogs and uses thereof
This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular...
Yellow anionic disazo dyes
The present invention relates to novel yellow anionic dyes, a process for their preparation, certain novel intermediates necessary for their preparation and the...
Method for synthesizing rare-earth oxo isopropoxide
Provided is a method for synthesizing a rare-earth oxo isopropoxide safely with a high yield, using a rare-earth metal, which is more inexpensive than anhydrous...
Pegylated amino acid derivatives and the process to synthesize the same
The present invention is a series of novel pegylated amino acid derivatives containing branched polyethylene glycols, which are either the same or different...
The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.
Compositions and methods of use for antibodies of c-Met
Antibodies and fragments that bind to the protein target c-Met, particularly to epitopes located in the c-Met extracellular domain, are provided, as are methods...
Ligands binding the complex of urokinase-type plasminogen activator (uPA)
and its receptor (uPAR) that inhibit...
Antibodies or other ligands specific for the binary uPA-uPAR complexes, for ternary complexes comprising uPA-uPAR and for complexes of uPAR and proteins other...
Monoclonal antibodies to basic fibroblast growth factor
The present invention is directed toward a neutralizing monoclonal antibody to basic fibroblast growth factor, a pharmaceutical composition comprising same, and...
High-affinity human antibodies to human protease-activated receptor-2
The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the...
Monoclonal antibodies to fibroblast growth factor receptor 2
The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods...
Less immunogenic binding molecules
The present invention provides a bispecific binding molecule, wherein said molecule comprises or consists of at least two domains whereby one of said at least...
Antibodies blocking fibroblast growth factor receptor activation and
methods of use thereof
The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other...
Immunoglobulin insertions, deletions and substitutions
An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more Fc.gamma.Rs, wherein said Fc variant comprises at...
Humanized anti-CD47 antibody
The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between...
Methods of administering porcine B-domainless fVIII
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more...
Use of tropoelastin for repair or restoration of tissue
The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic...
Human interferon-beta mutein
The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or...
Ryanodine receptor polypeptides
The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis...
Teleost derived antimicrobial polypeptides
The invention is directed to an isolated polypeptide which (a) is obtainable from a teleost; (b) has antimicrobial activity; (c) binds to oligoguanosine and/or...
Prostate cancer diagnosis and treatment
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis...
Purification processes for echinocandin-type compounds
The present invention provides a method of preparing and purifying echinocandin-type compounds, such as pneumocandin Bo, WF 11899A, and echinocandin B. These...
Process to modify polymeric materials and resulting compositions
Disclosed is a method for modifying a polymer by carrying out a thermally-induced reaction in a mixing apparatus having a high shear environment and...
Membrane separation process for removing residuals from
This invention relates to a process for preparing polyamine-epihalohydrin resins having reduced levels of residuals. The process comprises (a) charging a...
Synthesis of conducting polymer nanofibers using an oligomer of a monomer
as an initiator
The present invention involves synthesizing conducting polymer nanofibers by mixing an oxidant solution with a monomer solution, which includes a monomer and an...
Solvent resistant polymers
What is disclosed relates to polymers that resist dissolution in organic solvents, are vasodilators, and are tunable explosives. These polymers also form...
Process for the direct manufacture of polyglycerol polyricinoleate
A process for manufacturing polymers of glycerin and hydroxyl fatty acids, for example, polyglycerol polyricinoleates, which mix a polyglycerol with a hydroxyl...
Multifunctional forms of polyoxazoline copolymers and drug compositions
comprising the same
The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically...
Polyester compositions containing cyclobutanediol having a certain
combination of inherent viscosity and...
Described are articles, comprising polyester based composition, comprising dicarboxylic acid component as terephthalic acid residues and optionally, aromatic...
Continuous polymer-analogous reaction of reactive silane monomers with
Functional polymers having silyl end groups are prepared in a continuous process by polymer analogous reaction of a reactive polymer and inter-reactive silane....
Precursor solution for polyimide/silica composite material, its
manufacture method, and polyimide/silica...
A process for preparing a precursor solution for polyimide/silica composite material and a process for forming a polyimide/silica composite material film on a...
A silicone-containing composition comprises the reaction product of a first component and an excess of an isocyanate component relative to the first component...
Fumaric acid derivatives and ophthalmic lenses using the same
Fumaric acid derivatives and ophthalmic lenses using them are disclosed. More specifically, a fumaric acid derivative having a hydrophilic group and a...
Phosphonic polymers having a phosphinate backbone and methods of making
and using thereof
Described herein are new phosphonic polymers and methods of making and using the same. The polymers are prepared by the polymerization of phosphonic acid...
The invention relates to polymers useful in optoelectronic devices and comprising structural unit of formula I: ##STR00001## wherein R.sup.1 and R.sup.2 are...
Surface active prepolymers with both fluorine-containing groups and
Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having polymerizable functionality that is...
Multi-functionalized high-trans elastomeric polymers
A method for preparing multi-functional high-trans elastomeric polymers that have various applications such as in vulcanizable rubber compositions, moisture...
Polyolefin solution polymerization process and polymer
A catalyst composition comprising a zirconium complex of a polyvalent aryloxyether and a polymerization processes employing the same, especially a continuous,...
Propylene based terpolymers
A propylene-based terpolymer comprising: a) from 10.0% by mol to 79.0% by mol of propylene derived units; b) from 89.5% by mol to 20.5% by mol of 1-butene...
Multi reactor process
This invention relates to the polymerization of ethylene polymers using a continuously stirred tank reactor (CSTR) that is connected in series to a tubular...
Slurry phase polymerisation process
A process comprising polymerising in a loop reactor of continuous tubular construction an olefin monomer optionally together with an olefin comonomer in the...
Systems and methods for fabricating polymers
Disclosed herein are various methods and systems for gas and liquid phase polymer production. In certain embodiments, the methods comprise manipulating...
Amine functional adducts and curable compositions comprising same
An amine functional adduct is obtained by admixing a stoichiometric excess of a cycloaliphatic diamine and a compound having an epoxide group and an alpha, beta...
Shape memory epoxy copolymer
The shape memory polymers disclosed are a reaction product of at least one reagent containing two active amino-hydrogen or two active phenolic-hydrogen with at...
Polylactic acid fiber yarn package, and textile products
Polylactic acid fibers excellent in wearing resistance and in the ability to smoothly pass through processing steps. The polylactic acid fibers contain a fatty...
Multimodal polyethylene material
The present invention relates to a polyethylene resin having a multimodal molecular weight distribution, said resin being further characterized in that it has a...
Interpolymer resin particles
Interpolymer resin particles comprised of 20% to 60% by weight of uncross-linked polyolefin e.g. polyethylene, polypropylene, and from 40% to 80% by weight...
Thermoplastic elastomer polyolefin in-reactor blends and molded articles
This invention relates to an in-reactor polymer blend comprising: (a) a first ethylene-containing polymer having a density of greater than 0.90 g/cm.sup.3 and a...