Modified vitamin K-dependent polypeptides
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in...
Human cytokine receptor
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides polynucleotides, vectors, cells,...
Schizophrenia-related isoform of KCNH2 and development of antipsychotic
The invention is related to a novel primate specific brain isoform of the potassium channel KCNH2 and genetic association with risk for schizophrenia.
Preparation of low bleeding anticoagulant fusion protein and its use
Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa....
Dual expression vector system and screening methods
The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect...
Protein hydrolysates and method of making
Methods of making protein hydrolysates are described. The methods may include the steps of providing a solution comprising protein, and adjusting a pH of the...
Swatch for testing the washing performance of an enzyme
The present invention relates to a swatch comprising a pH-indicator substance and a substrate for an enzyme for testing the washing performance of the enzyme,...
Compositions and methods for detecting phosphomonoester
The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound...
Oxidative chromogenic compound or salt thereof and production method
thereof, and reagent composition and test...
It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity....
.beta.-galactosidase donor fragments
Truncated fragments of the small fragment of .beta.-galactosidase are provided that have low affinity for the large fragment of .beta.-galactosidase and provide...
Diagnosis and therapy of cancer using SGP28-related molecules
The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding...
Methods for the diagnosis of genitourinary cancer
Methods for the diagnosis of genitourinary (GU) cancer are provided. In particular, urine has been found to contain significant levels of thromboxane receptor...
Genes from the 20q13 amplicon and their uses
The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in...
Diagnose device for measuring the ratio of proteins with similar structure
The present invention relates to a diagnostic device for measuring the ratio of similar structural proteins among the proteins secreted in a liquid test sample...
Quantitation of cellular DNA and cell numbers using element labeling
Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element...
Antibodies specific to antigens of Bartonella henselae and use of these
antigens in immunoassays
Disclosed are antibodies that bind to the antigenic proteins GroES, RpIL, GroEL, SodB, UbiG, the ABC transporter, and an expressed antigenic protein of unknown...
Assessment of patients with sepsis to determine a requirement for
therapeutic intervention with an...
Methods of selecting patients with sepsis for treatment with an anti-inflammatory and/or anticoagulatory agent are provided.
Anti-EphB4 antibodies and methods using same
The invention provides anti-EphB4 antibodies, and compositions comprising and methods of using these antibodies.
Fragments of fluorescent proteins for protein fragment complementation
The present invention is directed to Protein-fragment Complementation Assays (PCAs) and assay compositions based on fluorescent proteins. The invention provides...
Inflammatory markers as tools in the detection and prevention of diabetes
mellitus and as tools to aid in the...
The invention involves methods for characterizing an individual's risk profile of developing future diabetes or complications of diabetes by obtaining a level...
Detection of Clostridium difficile
The invention provides methods to detect C. difficile in biological samples using real-time PCR. Primers and probes for the detection of C. difficile are...
Markers for diagnosis of pulmonary inflammation and methods related
The present invention is related to the novel discovery of a number of genes that were identified as systemic markers of pulmonary inflammation. This discovery...
IL-1 gene cluster, insulin resistance and coronary artery disease
associated polymorphisms and haplotypes and...
The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster--including the structure...
Method for determining risk of relapse of breast cancer following
tamoxifen adjuvant therapy
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of...
Method of profiling gene expression in a subject having disease
The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of...
Method for inhibiting telomerase reaction using an anionic phthalocyanine
An object of the present invention is to provide a method for inhibiting a DNA extension reaction by telomerase. More specifically, the present invention...
Nucleic acid hybridization assay method
A cleavable signal element applicable to quantitative and qualitative assay devices, using a cleavable technique specifically responsive to a complementary...
Method for cloning and expressing target gene by homologous recombination
A method for cloning and expressing a target gene by homologous recombination, and more particularly a method for cloning and expressing a target gene by...
Method for screening for a tobiano coat color genotype
A method for screening for a Tobiano genotype includes obtaining a nucleic acid from an equine animal, and analyzing the nucleic acid for the presence of an...
System and method for nucleotide sequence profiling for sample
The invention includes a method of sample profiling for identification. The method includes the steps of performing less than four nucleotide-specific chemical...
Detection of ESR1 amplification in breast cancer
The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative breast disease as responsive to anti-estrogen...
Process for typing of HCV isolates
The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for...
Modulation of exportin 5 expression
Compounds, compositions and methods are provided for modulating the expression of exportin 5. The compositions comprise oligonucleotides, targeted to nucleic...
Gene products differentially expressed in cancerous cells and their
methods of use II
The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These ...
RNA-interference by single-stranded RNA molecules
The present invention relates to sequence and structural features of single-stranded (ss) RNA molecules required to mediate target-specific nucleic acid...
Method and compositions for immunization with the Pseudomonas V antigen
A method of inhibiting, moderating or diagnosing Pseudomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient...
Identifier and nucleic acid amplification method of verification using the
There is provided an identification technique that can consistently maintain a set of information specifying a specimen through all the processes from the...
Proinflammatory nucleic acids
The present invention provides compositions and methods for identifying and utilizing proinflammatory nucleic acids. In particular, this invention relates to...
Device and method for high-throughput quantification of mRNA from whole
Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More...
Delivery of dsRNA to arthropods
The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the...
DNA vaccine for treating or preventing cervical cancer comprising a gene
encoding HPV protein
Disclosed herein is a DNA vaccine for treating cervical cancer including an E5 gene of human papillomavirus (HPV). Also, disclosed is a combination DNA vaccine...
A pattern is formed by coating a chemically amplified positive resist composition comprising a resin comprising acid labile group-containing recurring units and...
Method of inhibiting photoresist pattern collapse
A method of inhibiting photoresist pattern collapse which includes the steps of providing a substrate; providing a photoresist layer on the substrate; exposing...
Photosensitive resin composition, photosensitive element comprising the
same, method of forming resist pattern,...
A photosensitive resin composition according to the invention comprises (A) a binder polymer, (B) a photopolymerizing compound with an ethylenic unsaturated...
Method of forming micro pattern of semiconductor device
The present invention relates to a method of forming a micro pattern of a semiconductor device. According to an aspect of the present invention, a first...
Method of synthesizing ITO electron-beam resist and method of forming ITO
pattern using the same
Provided is a method of synthesizing an ITO electron beam resist and a method of forming an ITO pattern. The ITO electron beam resist is synthesized by...
Photocurable and thermosetting resin composition, cured product thereof,
and printed circuit board
The present invention provides a photocurable and thermosetting resin composition having excellent surface curability and deep curability, allowing pattern...
Resist composition and patterning process
A copolymer of an alkali-soluble (.alpha.-trifluoromethyl)-acrylate and a norbornene derivative is useful as an additive to a resist composition. When processed...
Image processing method and image processing apparatus
To provide an image processing method including at least one of recording an image onto a thermoreversible recording medium in which transparency or color tone...
Method for formation of miniaturized pattern and resist substrate
treatment solution for use in the method
The present invention provides a method for miniaturizing a pattern without seriously increasing the production cost or impairing the production efficiency....