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Patent # Description
US-8,129,404 Compounds and uses thereof
N-[3-(4-Cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-- 4-trifluoromethyl-benzenesulfonamide, ...
US-8,129,403 Chemical compounds
This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds...
US-8,129,402 Screening molecules with anti-prion activity: kits, methods and screened molecules
The invention concerns screening molecules with anti-prion activity. More particularly, it concerns kits for screening molecules with anti-prion activity...
US-8,129,401 Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their...
The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers,...
US-8,129,400 Condensation compound between fluorinated cyclopentane ring and aromatic ring, and process for producing the same
A condensation compound of a fluorinated cyclopentane ring and an aromatic ring, which is useful, for example, for electronic materials, and a process for...
US-8,129,399 Aminopyrimidines useful as kinase inhibitors
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions...
US-8,129,398 HIV integrase inhibitors
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into...
US-8,129,397 Substituted thieno[2,3-d]pyrimidines as AMPA modulators
The present invention relates to a heterocyclic derivative according to formula I ##STR00001## wherein the variables are defined as in the specification, or...
US-8,129,396 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and ...
2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase...
US-8,129,395 4,5-disubstituted-2-aryl pyrimidines
4,5-disubstituted-2-arypyrimidines of Formula I and Formula II are provided: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.8, R.sub.9, A and Ar are...
US-8,129,394 Heteroaryl-substituted imidazole compounds and uses thereof
Novel imidazole compounds of the general formula ##STR00001## are disclosed, wherein R.sup.1 and R.sup.2 comprise heteroaryl groups. These compounds and...
US-8,129,393 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
Compounds of general formula: ##STR00001## as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They...
US-8,129,391 N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpipera- zin-1-yl)benzamide and salts thereof
There is provided a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture...
US-8,129,390 Carboxamide, sulfonamide and amine compounds and methods for using the same
Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the...
US-8,129,389 Substituted oxindole derivatives, medicaments containing the latter and use thereof
The invention relates to novel oxindole derivatives of general formula (I), in which the substituents A, B, R.sup.1, R.sup.2 and R.sup.3 are defined as cited in...
US-8,129,388 Therapeutic agents useful for treating pain
The present invention discloses compounds of formula: ##STR00001## where Ar.sub.1, Ar.sub.2, X, R.sub.3, and m are as disclosed herein or a pharmaceutically...
US-8,129,387 Substituted 5,6-dihydroimidazo[1,5-F]pteridines useful as protein kinase inhibitors
The present invention relates to substituted 5,6-dihydroimidazo[1,5-f]pteridines of formula I: ##STR00001## which are useful as inhibitors of protein kinase....
US-8,129,386 Fused azole-pyrimidine derivatives
The present invention relates to novel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The...
US-8,129,385 Substituted 5-hydroxy-3,4,6,9,9a, 10-hexanhydro-2h-1-oxa04a,8a-diaza-anthracene-6,10-dioness
The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-di- ones useful as anti-HIV...
US-8,129,384 Imidazo[1,2-a]pyrazines as orexin receptor antagonists
This invention relates to imidazopyrazine substituted piperidine derivatives and their use as pharmaceuticals.
US-8,129,383 Aminopterin dosage forms and methods for inflammatory disorders
There is disclosed dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a...
US-8,129,382 Compounds, methods and pharmaceutical compositions for inhibiting PARP
The present invention provides compounds which inhibit poly(ADP-ribose) polymerase ("PARP"), compositions containing these compounds and methods for using these...
US-8,129,381 Caspase inhibitors and uses thereof
The present invention relates to compounds of formula I: ##STR00001## useful as inhibitors of caspases. The present invention also provides pharmaceutically...
US-8,129,380 Phthalazinone derivatives
A compound of the formula (I): ##STR00001## wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH...
US-8,129,379 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases...
This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or...
US-8,129,378 Substituted oxazolidinones and their use in the field of blood coagulation
The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) ##STR00001## processes for their...
US-8,129,377 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: ##STR00001## wherein R.sup.1...
US-8,129,376 Piperidine derivatives as inhibitors of stearoyl-CoA desaturase
The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing...
US-8,129,375 Isoindoline compounds and methods of their use
Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating,...
US-8,129,374 Method of using imidazolothiazole compounds for the treatment of disease
Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or...
US-8,129,373 Carbonyl compounds
Novel compounds of the formula (I), in which D, E, G, W, X, Y, T, R.sup.1 and R.sup.2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa...
US-8,129,372 Compounds having NPY Y5 receptor antagonistic activity
This invention provides a compound of the formula (I): ##STR00001## a pharmaceutically acceptable salt or solvate thereof, wherein R.sup.1 is substituted or...
US-8,129,371 Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors
The invention relates to thienopyrimidine and pyrazolopyrimidine compounds of the Formulas (Ia) and (IIa), ##STR00001## or a pharmaceutically acceptable salt...
US-8,129,370 Use of oxicam compounds
The invention relates to the use of lornoxicam or analogues thereof which inhibit cyclo-oxygenase 1 and cyclo-oxygenase 2 (COX 1 and COX 2), cannot penetrate...
US-8,129,369 Antifungal compounds containing benzothiazinone, benzoxazinone or benzoxazolinone and process thereof
The present invention discloses novel compounds of the Formula (1), comprising benzothiazinone, benzoxazinone or benzoxazolinone moieties having antifungal...
US-8,129,368 5,6-dihydro-1H-pyridin-2-one compounds
The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of formula: ##STR00001## wherein R is C.sub.1-C.sub.6 alkyl or (Aryl)CH.sub.2-,and...
US-8,129,367 Compounds for the treatment of Hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C...
US-8,129,366 VLA-4 inhibitory drug
There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally. A...
US-8,129,365 Water-soluble, fluorescent compounds for detection of potassium ions
The invention provides chromoionophore compounds comprising a triazacryptand (TAC) K.sup.+ ionophore conjugated to at least a first chromophoric moiety (e.g.,...
US-8,129,364 Formulations and methods for treating rhinosinusitis
The invention involves methods and formulations for treating or preventing rhinosinusitis, including fungus-induced rhinosinusitis in mammals. In one...
US-8,129,363 Method for obtaining conjugated estrogen mixtures from pregnant mare urine and use of a macroporous resin in...
The present invention relates to a method for obtaining a natural mixture of conjugated estrogens from urine of pragnant mares (PMU) and use of a macroporous...
US-8,129,362 Combination/association of adapalene and benzoyl peroxide for treating acne lesions
Acne lesions, whether of inflammatory and/or non-inflammatory type, are simultaneously or sequentially treated and their number reduced, via daily topical...
US-8,129,361 Amine compound and pharmaceutical use thereof
Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the...
US-8,129,360 Utilization of phosphatidylserine in the treatment of attention deficit syndrome (ADHS)
The invention concerns the use of phosphatidylserine (PS), lyso-phosphatidylserine or/and a physiologically acceptable salt thereof for the treatment of the...
US-8,129,359 Composition and method for treating post-surgical pain
A composition for reducing pain at a surgical wound site or trauma site comprising oxidized regenerated cellulose and a non-steroidal anti-inflammatory drug or...
US-8,129,358 Substituted pyrazole and triazole compounds as KSP inhibitors
Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of...
US-8,129,357 Method of making and using an adenosine analogue
This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic...
US-8,129,356 Bmx mediated signal transduction in irradiated vascular endothelium
Provided are methods for modulating the proliferation of cells and tissues. In some embodiments, the methods include administering to a subject an effective...
US-8,129,355 Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand...
US-8,129,354 Treatment of neurological disorders by dsRNA administration
The present invention relates to methods to treat neurological disorders comprising intrathecal injection of an effective amount of a double-stranded (ds) RNA...
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