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Patent # Description
US-8,134,011 Oxazolidinium compounds and use as hydrate inhibitors
Oxazolidinium compounds are formed by the reaction of a halohydrin or an epoxide with a secondary amine and an aldehyde or a ketone. The oxazolidinium compounds...
US-8,134,010 Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is...
US-8,134,009 Process for the oxidation of secondary amines into the corresponding nitroxides
The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic...
US-8,134,008 Preparation of amorphous hydrous esomeprazole magnesium
A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the...
US-8,134,007 Pyridine derivatives
The present invention relates to compounds of the formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, to processes for the preparation of,...
US-8,134,006 Dialkylphenyl compounds having .beta..sub.2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention relates to compounds of formula I: ##STR00001## wherein R.sup.1 and R.sup.2 are as defined in the specification, or a pharmaceutically...
US-8,134,005 Preparation and use of magnesium amides
The present application relates to mixed Mg/Li amides of the general formula R1R2N--Mg(NR3R4)mX,.m zLiY (II) wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are,...
US-8,134,004 Substituted N-bicyclicalkyl bicycliccarboxyamide compounds
This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such...
US-8,134,003 Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of...
US-8,134,002 Process for preparing oxymorphone
Methods are provided which include converting oripavine to other opiates, including converting oripavine to 14-hydroxymorphinone and/or converting ...
US-8,134,001 Spiroindolinone derivatives
There are provided compounds of the formula ##STR00001## and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R' are as...
US-8,134,000 Imidazolyl pyrimidine inhibitor compounds
A compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition...
US-8,133,999 Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one
6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl ...
US-8,133,998 Bicyclic pyrimidine derivatives as calcium channel blockers
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel...
US-8,133,997 2,4-dioxopyrimidine-based mesoionic pigments
The invention relates to the dimeric compound of formula (II) ##STR00001## wherein the two monomer-units are linked with each other either via R.sup.3 or via...
US-8,133,996 Process for the preparation of ethyl-N-(2,3-dichloro-6-nitrobenzyl)glycine hydrochloride
The invention relates to a process for the preparation of anagrelide, and for the preparation of intermediates for use in preparing anagrelide. The invention...
US-8,133,995 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases...
This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and...
US-8,133,994 Preparation of aprepitant
A process for preparing aprepitant.
US-8,133,993 Hydrogenolytic denitration of polynitro compounds: pentanitrohexaazaisowurtzitane
A method for synthesizing pentanitrohexaazaisowurtzintane under neutral reaction conditions. Which synthesis involves treating a solution of ...
US-8,133,992 Azepinoindole and pyridoindole derivatives as pharmaceutical agents
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating...
US-8,133,991 Allergen inactivating agent
An allergen inactivating agent is provided which has no adverse effects on the human body and which does not cause problems such as color development. An...
US-8,133,990 6-position highly acetylated cellulose diacetate and process for producing the same
Disclosed is a cellulose diacetate comprising a 6-position highly acetylated cellulose diacetate having a 6-percent viscosity of 40 to 600 mPas, and having a...
US-8,133,989 Nucleic acid primer/construct compositions
This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear...
US-8,133,988 Tissue specific promoters
The invention relates to tissue specific promoters which can be used in plants for one or more of the following purposes: a. altering carbohydrate metabolism b....
US-8,133,987 Primer array synthesis and validation
Methods are presented for generating large sets for polymers. The methods employ high density oligonucleotide array.
US-8,133,986 Methylated CpG island amplification (MCA)
The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive...
US-8,133,985 Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same
The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof....
US-8,133,984 Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of...
The invention relates to novel oligonucleotides comprising a signalling pair and at least two hydrophobic nucleotides. The oligonucleotide analogues are useful...
US-8,133,983 Agonistic binding molecules to the human OX40 receptor
The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also...
US-8,133,982 Fc.gamma.RIIB specific antibodies and methods of use thereof
The present invention relates to humanized Fc.gamma.RIIB antibodies, fragments, and variants thereof that bind human Fc.gamma.RIIB with a greater affinity than...
US-8,133,981 Therapeutic use of anti-CS1 antibodies
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a...
US-8,133,980 Antibodies and functional fragments thereof that specifically bind an RF-amide peptide or a precursor thereof
The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention...
US-8,133,979 Antibodies against human angiopoietin 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions...
US-8,133,978 Humanised anti-interleukin-18 antibody
The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are...
US-8,133,977 Polymer-factor VIII moiety conjugates
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a...
US-8,133,976 Methods of use of the TACI/TACI-L interaction
The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate...
US-8,133,975 Coagulation factor VII polypeptides
The present invention relates to novel coagulation Factor VII polypeptides, polynucleotide constructs encoding such polypeptides, as well as vectors and host...
US-8,133,974 Ferroportin1 nucleic acids, proteins, antibodies and methods
Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1,...
US-8,133,973 Immunogenic compositions for Chlamydia trachomatis
The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the Chlamydia trachomatis serovars. Such changes in...
US-8,133,972 IgE antigenic peptides
Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with...
US-8,133,971 Polypeptide specifically bound to phosphatidylserine and the use thereof
The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino...
US-8,133,970 Oxidized and maleated derivative compositions
Oxidized and maleated derivative compositions, such as chemically modified oxidized and maleated tall oil fatty acid compositions, can be prepared and used in a...
US-8,133,969 Method for removing a carbonization catalyst from a graphene sheet and method for transferring the graphene sheet
A method for removing a carbonization catalyst from a graphene sheet, the method includes contacting the carbonization catalyst with a salt solution, which is...
US-8,133,968 Poly(orthoester) polymers, and methods of making and using same
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for...
US-8,133,967 Restaurant smallware comprising polyester compositions formed from 2,2,4,4-tetramethyl-1,3-cyclobutanediol and...
Described are restaurant smallware, comprising polyester based composition, comprising dicarboxylic acid component as terephthalic acid residues and optionally,...
US-8,133,966 Oxymethylene copolymers and the use thereof and process for the preparation of oxymethylene copolymers
Oxymethylene copolymers having a high proportion of terminal alkyl ether groups and having terminal hydroxyalkylene groups are described. These polymers are...
US-8,133,965 High silicon content siloxane polymers for integrated circuits
Thin films are disclosed that are suitable as thin films in IC's and for other similar applications. In particular, the invention concerns thin films comprising...
US-8,133,964 Single-component coating having alkoxysilane-terminated N-substituted urea resins
The coating described herein attempts to provide this solution by synthesizing alkoxysilane-terminated N-substituted urea resins, then formulating them into...
US-8,133,963 Polypropylene composition for air quenched blown films
The invention is directed to a polypropylene resin, which is suitable for manufacturing an air quenched blown film. The resin has a melt flow rate of greater...
US-8,133,962 Ink composition for color filter and color filter
A heat-curable ink composition and a color filter produced using the ink composition are provided. The ink composition and the color filter are highly resistant...
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