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Oxazolidinium compounds and use as hydrate inhibitors
Oxazolidinium compounds are formed by the reaction of a halohydrin or an epoxide with a secondary amine and an aldehyde or a ketone. The oxazolidinium compounds...
Thiazole-based nitric oxide donors having aryl substituent(s) and uses
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is...
Process for the oxidation of secondary amines into the corresponding
The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic...
Preparation of amorphous hydrous esomeprazole magnesium
A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the...
The present invention relates to compounds of the formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, to processes for the preparation of,...
Dialkylphenyl compounds having .beta..sub.2 adrenergic receptor agonist
and muscarinic receptor antagonist activity
This invention relates to compounds of formula I: ##STR00001## wherein R.sup.1 and R.sup.2 are as defined in the specification, or a pharmaceutically...
Preparation and use of magnesium amides
The present application relates to mixed Mg/Li amides of the general formula R1R2N--Mg(NR3R4)mX,.m zLiY (II) wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are,...
Substituted N-bicyclicalkyl bicycliccarboxyamide compounds
This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such...
Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of...
Process for preparing oxymorphone
Methods are provided which include converting oripavine to other opiates, including converting oripavine to 14-hydroxymorphinone and/or converting ...
There are provided compounds of the formula ##STR00001## and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R' are as...
Imidazolyl pyrimidine inhibitor compounds
A compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition...
Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one
6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl ...
Bicyclic pyrimidine derivatives as calcium channel blockers
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel...
2,4-dioxopyrimidine-based mesoionic pigments
The invention relates to the dimeric compound of formula (II) ##STR00001## wherein the two monomer-units are linked with each other either via R.sup.3 or via...
Process for the preparation of ethyl-N-(2,3-dichloro-6-nitrobenzyl)glycine
The invention relates to a process for the preparation of anagrelide, and for the preparation of intermediates for use in preparing anagrelide. The invention...
Substituted 4-amino-pyrrolotriazine derivatives useful for treating
hyper-proliferative disorders and diseases...
This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and...
Preparation of aprepitant
A process for preparing aprepitant.
Hydrogenolytic denitration of polynitro compounds:
A method for synthesizing pentanitrohexaazaisowurtzintane under neutral reaction conditions. Which synthesis involves treating a solution of ...
Azepinoindole and pyridoindole derivatives as pharmaceutical agents
Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating...
Allergen inactivating agent
An allergen inactivating agent is provided which has no adverse effects on the human body and which does not cause problems such as color development. An...
6-position highly acetylated cellulose diacetate and process for producing
Disclosed is a cellulose diacetate comprising a 6-position highly acetylated cellulose diacetate having a 6-percent viscosity of 40 to 600 mPas, and having a...
Nucleic acid primer/construct compositions
This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear...
Tissue specific promoters
The invention relates to tissue specific promoters which can be used in plants for one or more of the following purposes: a. altering carbohydrate metabolism b....
Primer array synthesis and validation
Methods are presented for generating large sets for polymers. The methods employ high density oligonucleotide array.
Methylated CpG island amplification (MCA)
The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive...
Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid
detecting device using the same
The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof....
Oligonucleotides comprising signalling pairs and hydrophobic nucleotides,
stemless beacons, for detection of...
The invention relates to novel oligonucleotides comprising a signalling pair and at least two hydrophobic nucleotides. The oligonucleotide analogues are useful...
Agonistic binding molecules to the human OX40 receptor
The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also...
Fc.gamma.RIIB specific antibodies and methods of use thereof
The present invention relates to humanized Fc.gamma.RIIB antibodies, fragments, and variants thereof that bind human Fc.gamma.RIIB with a greater affinity than...
Therapeutic use of anti-CS1 antibodies
The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a...
Antibodies and functional fragments thereof that specifically bind an
RF-amide peptide or a precursor thereof
The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention...
Antibodies against human angiopoietin 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions...
Humanised anti-interleukin-18 antibody
The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are...
Polymer-factor VIII moiety conjugates
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a...
Methods of use of the TACI/TACI-L interaction
The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate...
Coagulation factor VII polypeptides
The present invention relates to novel coagulation Factor VII polypeptides, polynucleotide constructs encoding such polypeptides, as well as vectors and host...
Ferroportin1 nucleic acids, proteins, antibodies and methods
Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1,...
Immunogenic compositions for Chlamydia trachomatis
The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the Chlamydia trachomatis serovars. Such changes in...
IgE antigenic peptides
Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with...
Polypeptide specifically bound to phosphatidylserine and the use thereof
The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino...
Oxidized and maleated derivative compositions
Oxidized and maleated derivative compositions, such as chemically modified oxidized and maleated tall oil fatty acid compositions, can be prepared and used in a...
Method for removing a carbonization catalyst from a graphene sheet and
method for transferring the graphene sheet
A method for removing a carbonization catalyst from a graphene sheet, the method includes contacting the carbonization catalyst with a salt solution, which is...
Poly(orthoester) polymers, and methods of making and using same
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for...
Restaurant smallware comprising polyester compositions formed from
Described are restaurant smallware, comprising polyester based composition, comprising dicarboxylic acid component as terephthalic acid residues and optionally,...
Oxymethylene copolymers and the use thereof and process for the
preparation of oxymethylene copolymers
Oxymethylene copolymers having a high proportion of terminal alkyl ether groups and having terminal hydroxyalkylene groups are described. These polymers are...
High silicon content siloxane polymers for integrated circuits
Thin films are disclosed that are suitable as thin films in IC's and for other similar applications. In particular, the invention concerns thin films comprising...
Single-component coating having alkoxysilane-terminated N-substituted urea
The coating described herein attempts to provide this solution by synthesizing alkoxysilane-terminated N-substituted urea resins, then formulating them into...
Polypropylene composition for air quenched blown films
The invention is directed to a polypropylene resin, which is suitable for manufacturing an air quenched blown film. The resin has a melt flow rate of greater...
Ink composition for color filter and color filter
A heat-curable ink composition and a color filter produced using the ink composition are provided. The ink composition and the color filter are highly resistant...