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| Patent # | Description |
|---|---|
| US-8,133,911 |
(R)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions
containing them The present invention relates to a novel class of (R)-4-(heteroaryl)phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic... |
| US-8,133,910 |
Thiophene derivatives as S1P1/EDGE1 receptor agonists The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as... |
| US-8,133,909 |
Heteroaromatic monoamides as orexinin receptor antagonists The present invention is concerned with novel sulfonamides of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Ar, Ar.sup.1, Ar.sup.2,... |
| US-8,133,908 |
Heteroaryl derivatives of
N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methy-
l}-2-amine Disclosed are N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methy- l}-2-heteroarylamine derivatives having the following formula: ... |
| US-8,133,907 |
Pyridine derivatives as dipeptedyl peptidase inhibitors The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (1); X is selected from CH, CF and N;... |
| US-8,133,906 |
Method of treating amblyopia The present invention relates to a method of treating or alleviating the symptoms of amblyopia. It is based on the discovery that repeated administration of a... |
| US-8,133,905 |
Biphenyl compounds useful as muscarinic receptor antagonists The invention provides compounds of formula I: ##STR00001## wherein a, b, c, m, n, q, r, W, Z.sup.1, Ar.sup.1, Z.sup.2, Y, R.sup.1, R.sup.2, and R.sup.3 are... |
| US-8,133,904 |
Cannabinoid receptor antagonists/inverse agonists useful for treating
obesity The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using... |
| US-8,133,903 |
Methods of use of inhibitors of phosphodiesterases and modulators of
nitric oxide, reactive oxygen species, and... The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis,... |
| US-8,133,902 |
Ammosamides as anticancer agents A compound having the general the general structure I is provided: (Formula I), wherein Z is a substituent selected from a group consisting of S and O; X is a... |
| US-8,133,901 |
3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl)
carbonylpiperidine derivatives as orexin receptor... The invention relates to piperidine compounds of formula (I): ##STR00001## wherein X--R.sup.1 represents --N(H)-pyrimidinyl, wherein said pyrimidinyl is... |
| US-8,133,900 |
Use of bi-aryl meta-pyrimidine inhibitors of kinases The invention provides methods of treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, and chronic eosinophilic leukemia... |
| US-8,133,899 |
Pyrrolo[2,3-d]pyrimidine compounds Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and... |
| US-8,133,898 |
Renin inhibitors The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9... |
| US-8,133,897 |
Phenylimidazole derivatives as PDE10A enzyme inhibitors This invention is directed to phenylimidazole compounds, which are PDE10A enzyme inhibitors useful for the treatment of neurological and psychiatric disorders. |
| US-8,133,896 |
Pyrimidine derivatives which are antagonist of the vitronectin receptor A subject of the invention is the compounds of formula (I); ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R have the meanings indicated in... |
| US-8,133,895 |
Fused pyrazine compounds useful for the treatment of degenerative and
inflammatory diseases Novel fused pyrazine compounds are disclosed that have a formula represented by the following: ##STR00001## The compounds may be prepared as pharmaceutical... |
| US-8,133,894 |
N-benzyl-4-methyleneamino-3-hydroxy-2-pyridones Compounds of Formula (I) ##STR00001## are effective in the treatment of a microbial infection. |
| US-8,133,893 |
Trazodone and trazodone hydrochloride in purified form A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one... |
| US-8,133,892 |
Compounds that are useful for improving pharmacokinetics Novel compounds of formula 1 ##STR00001## or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase. |
| US-8,133,891 |
Tricyclic anilide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where A.sup.1, A.sup.2, B.sup.1, B.sup.2, B.sup.3, B.sup.4, D.sup.1, D.sup.2, J, K, T, U, V, W,... |
| US-8,133,890 |
Combination of brimonidine and timolol for topical ophthalmic use Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering... |
| US-8,133,889 |
Dihydroindolone compounds, a process for their preparation and
pharmaceutical compositions containing them Compounds of formula (I): ##STR00001## wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO.sub.2 group,... |
| US-8,133,888 |
Hydrazide containing taxane conjugates The present invention relates to compounds of formula I or salts thereof, wherein, R.sub.1 is selected from the group consisting of hydrogen and R.sub.4;... |
| US-8,133,887 |
Oxaphenanthrene derivatives The invention relates to compounds of the formula (I), in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and A have the meanings indicated, and to processes for... |
| US-8,133,886 |
Heterobicyclic carboxamides as inhibitors for kinases The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a... |
| US-8,133,885 |
Non steroidal glucocorticoid receptor modulators The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to... |
| US-8,133,884 |
Compounds for the treatment of hepatitis C The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C... |
| US-8,133,883 |
Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in... |
| US-8,133,882 |
Quinolone derivative or pharmaceutically acceptable salt thereof Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; --N(R.sup.0)C(O)-lower alkylene-CO.sub.2R.sup.0, lower ... |
| US-8,133,881 |
Carbohydrate conjugates to prevent abuse of controlled substances The invention provides a "street-safe" version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or... |
| US-8,133,880 |
Purine derivatives and methods of use thereof The invention relates to Purine Derivatives having the formula; ##STR00001## The invention also relates to pharmaceutical compositions comprising an effective... |
| US-8,133,879 |
Myocardial perfusion imaging methods and compositions The present disclosure provides 2-adenosine N-pyrazole compounds of structural formula shown below that are potent and selective agonists for A.sub.2A adenosine... |
| US-8,133,878 |
Methods for treating restenosis Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a... |
| US-8,133,877 |
Composition comprising an antisense sequence implicated in the regulation
of angiogenesis Therapeutic compositions used in the field of angiogenesis include nucleotide sequences of genes, the involvement of the genes in the angiogenesis mechanism... |
| US-8,133,876 |
Oligomeric compounds and compositions for use in modulation of small
non-coding RNAs Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric... |
| US-8,133,875 |
Method for inhibiting scavenger receptor-A and increasing immune response
to antigens Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent... |
| US-8,133,874 |
Oligonucleotide or its functional homologue, a composition comprising the
same and a method of treating B cell... The invention provides an oligonucleotide with a sequence of SEQ ID NO: 1 or its functional homolgue, a composition comprising the same and a method for... |
| US-8,133,873 |
Recombinant chemokine-antigen vaccine A recombinant gene sequence that comprises human SLC gene, antigen gene, and IgG1-Fc fragment gene, wherein the SLC gene is linked upstream to the antigen gene,... |
| US-8,133,872 |
Use of nicotinic acid adenine dinucleotide phosphate or derivative thereof
as agent for treating type-2 diabetes The administration of nicotinic acid adenine dinucleotide phosphate (NAADP) or a pharmaceutically acceptable salt thereof to a host in need thereof for the... |
| US-8,133,871 |
Dihydropseudoerythromycin derivatives A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a... |
| US-8,133,870 |
Therapeutic furopyrimidines and thienopyrimidines The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic... |
| US-8,133,869 |
Compositions containing poly[beta(1,4)-2-amino-2-deoxyglucopyranose]
oligomers in a solution of modified lignin... The present invention refers to biocidal mixtures with disinfecting and microbicidal activity which also enhance root growth, containing as active ingredients... |
| US-8,133,868 |
Dipeptides for prevention of muscle breakdown and microbial infection The subject invention provides dipeptides useful in promoting healthy muscle tissues as well as effective immune responses. The dipeptides of the subject... |
| US-8,133,867 |
Method for treating rheumatoid arthritis with an antibody that binds to a
hepatocyte growth factor receptor A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid... |
| US-8,133,866 |
Method for inhibiting new tissue growth in blood vessels in a patient
subjected to blood vessel injury This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which... |
| US-8,133,865 |
von Willebrand factor- and factor VIII-polymer conjugates having a
releasable linkage The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making... |
| US-8,133,864 |
PAR-2 agonist The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a... |
| US-8,133,863 |
Stabilizing alkylglycoside compositions and methods thereof The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,... |
| US-8,133,862 |
Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients... |
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