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Patent # Description
US-8,133,911 (R)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them
The present invention relates to a novel class of (R)-4-(heteroaryl)phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic...
US-8,133,910 Thiophene derivatives as S1P1/EDGE1 receptor agonists
The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as...
US-8,133,909 Heteroaromatic monoamides as orexinin receptor antagonists
The present invention is concerned with novel sulfonamides of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Ar, Ar.sup.1, Ar.sup.2,...
US-8,133,908 Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methy- l}-2-amine
Disclosed are N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methy- l}-2-heteroarylamine derivatives having the following formula: ...
US-8,133,907 Pyridine derivatives as dipeptedyl peptidase inhibitors
The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (1); X is selected from CH, CF and N;...
US-8,133,906 Method of treating amblyopia
The present invention relates to a method of treating or alleviating the symptoms of amblyopia. It is based on the discovery that repeated administration of a...
US-8,133,905 Biphenyl compounds useful as muscarinic receptor antagonists
The invention provides compounds of formula I: ##STR00001## wherein a, b, c, m, n, q, r, W, Z.sup.1, Ar.sup.1, Z.sup.2, Y, R.sup.1, R.sup.2, and R.sup.3 are...
US-8,133,904 Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using...
US-8,133,903 Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and...
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis,...
US-8,133,902 Ammosamides as anticancer agents
A compound having the general the general structure I is provided: (Formula I), wherein Z is a substituent selected from a group consisting of S and O; X is a...
US-8,133,901 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor...
The invention relates to piperidine compounds of formula (I): ##STR00001## wherein X--R.sup.1 represents --N(H)-pyrimidinyl, wherein said pyrimidinyl is...
US-8,133,900 Use of bi-aryl meta-pyrimidine inhibitors of kinases
The invention provides methods of treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, and chronic eosinophilic leukemia...
US-8,133,899 Pyrrolo[2,3-d]pyrimidine compounds
Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and...
US-8,133,898 Renin inhibitors
The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9...
US-8,133,897 Phenylimidazole derivatives as PDE10A enzyme inhibitors
This invention is directed to phenylimidazole compounds, which are PDE10A enzyme inhibitors useful for the treatment of neurological and psychiatric disorders.
US-8,133,896 Pyrimidine derivatives which are antagonist of the vitronectin receptor
A subject of the invention is the compounds of formula (I); ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R have the meanings indicated in...
US-8,133,895 Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
Novel fused pyrazine compounds are disclosed that have a formula represented by the following: ##STR00001## The compounds may be prepared as pharmaceutical...
US-8,133,894 N-benzyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I) ##STR00001## are effective in the treatment of a microbial infection.
US-8,133,893 Trazodone and trazodone hydrochloride in purified form
A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one...
US-8,133,892 Compounds that are useful for improving pharmacokinetics
Novel compounds of formula 1 ##STR00001## or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
US-8,133,891 Tricyclic anilide spirolactam CGRP receptor antagonists
The present invention is directed to compounds of Formula I: I (where A.sup.1, A.sup.2, B.sup.1, B.sup.2, B.sup.3, B.sup.4, D.sup.1, D.sup.2, J, K, T, U, V, W,...
US-8,133,890 Combination of brimonidine and timolol for topical ophthalmic use
Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering...
US-8,133,889 Dihydroindolone compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein: m and n represent 1 or 2, A represents a pyrrolyl group, X represents a C(O), S(O) or SO.sub.2 group,...
US-8,133,888 Hydrazide containing taxane conjugates
The present invention relates to compounds of formula I or salts thereof, wherein, R.sub.1 is selected from the group consisting of hydrogen and R.sub.4;...
US-8,133,887 Oxaphenanthrene derivatives
The invention relates to compounds of the formula (I), in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and A have the meanings indicated, and to processes for...
US-8,133,886 Heterobicyclic carboxamides as inhibitors for kinases
The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a...
US-8,133,885 Non steroidal glucocorticoid receptor modulators
The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to...
US-8,133,884 Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C...
US-8,133,883 Compositions containing piperacillin and tazobactam useful for injection
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in...
US-8,133,882 Quinolone derivative or pharmaceutically acceptable salt thereof
Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; --N(R.sup.0)C(O)-lower alkylene-CO.sub.2R.sup.0, lower ...
US-8,133,881 Carbohydrate conjugates to prevent abuse of controlled substances
The invention provides a "street-safe" version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or...
US-8,133,880 Purine derivatives and methods of use thereof
The invention relates to Purine Derivatives having the formula; ##STR00001## The invention also relates to pharmaceutical compositions comprising an effective...
US-8,133,879 Myocardial perfusion imaging methods and compositions
The present disclosure provides 2-adenosine N-pyrazole compounds of structural formula shown below that are potent and selective agonists for A.sub.2A adenosine...
US-8,133,878 Methods for treating restenosis
Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a...
US-8,133,877 Composition comprising an antisense sequence implicated in the regulation of angiogenesis
Therapeutic compositions used in the field of angiogenesis include nucleotide sequences of genes, the involvement of the genes in the angiogenesis mechanism...
US-8,133,876 Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric...
US-8,133,875 Method for inhibiting scavenger receptor-A and increasing immune response to antigens
Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent...
US-8,133,874 Oligonucleotide or its functional homologue, a composition comprising the same and a method of treating B cell...
The invention provides an oligonucleotide with a sequence of SEQ ID NO: 1 or its functional homolgue, a composition comprising the same and a method for...
US-8,133,873 Recombinant chemokine-antigen vaccine
A recombinant gene sequence that comprises human SLC gene, antigen gene, and IgG1-Fc fragment gene, wherein the SLC gene is linked upstream to the antigen gene,...
US-8,133,872 Use of nicotinic acid adenine dinucleotide phosphate or derivative thereof as agent for treating type-2 diabetes
The administration of nicotinic acid adenine dinucleotide phosphate (NAADP) or a pharmaceutically acceptable salt thereof to a host in need thereof for the...
US-8,133,871 Dihydropseudoerythromycin derivatives
A compound represented by the formula [I] wherein each symbol is as defined in the specification or a pharmacologically acceptable salt thereof, and a...
US-8,133,870 Therapeutic furopyrimidines and thienopyrimidines
The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic...
US-8,133,869 Compositions containing poly[beta(1,4)-2-amino-2-deoxyglucopyranose] oligomers in a solution of modified lignin...
The present invention refers to biocidal mixtures with disinfecting and microbicidal activity which also enhance root growth, containing as active ingredients...
US-8,133,868 Dipeptides for prevention of muscle breakdown and microbial infection
The subject invention provides dipeptides useful in promoting healthy muscle tissues as well as effective immune responses. The dipeptides of the subject...
US-8,133,867 Method for treating rheumatoid arthritis with an antibody that binds to a hepatocyte growth factor receptor
A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid...
US-8,133,866 Method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury
This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which...
US-8,133,865 von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making...
US-8,133,864 PAR-2 agonist
The present invention relates to a pharmaceutical composition for preventing/treating conditions associated with PAR-2. The present invention also relates to a...
US-8,133,863 Stabilizing alkylglycoside compositions and methods thereof
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity,...
US-8,133,862 Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency
The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients...
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