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Patent # Description
US-8,138,352 Method for producing asymmetric tetrasubstituted carbon atom-containing compound
The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial...
US-8,138,351 Treatment of duchenne muscular dystrophy
Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d] oxazole useful in the treatment of Duchenne muscular dystrophy.
US-8,138,350 N'-cyano-N-halogenalkylimidamide derivatives
The present application relates to novel substituted N'-cyano-N-halogenalkylimidamide derivatives, to processes for their preparation and to their use for...
US-8,138,349 Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate
The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical...
US-8,138,348 Methods for oligomerizing olefins with chromium pyridine mono-oxazoline catalysts
The present invention provides a method of producing oligomers of olefins, comprising reacting olefins with a chromium based catalyst under oligomerization...
US-8,138,347 Quinoline derivatives as PI3 kinase inhibitors
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease...
US-8,138,346 Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and ...
US-8,138,345 Diamide compounds having muscarinic receptor antagonist and .beta..sub.2 adrenergic receptor agonist activity
This invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor...
US-8,138,344 Process for the preparation of rapamycin derivatives
Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32-hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an...
US-8,138,343 Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
A crystalline polymorph of 7-ethyl-10-hydroxycamptothecin exhibiting an X-ray diffraction pattern having peaks at 10.9.+-.0.2, 13.2.+-.0.2, 23.9.+-.0.2, and...
US-8,138,342 11.beta.-hydroxysteroid dehydrogenase type 1 active spiro compounds
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the...
US-8,138,341 Intermediate compounds useful for the manufacture of dihydropteridinones
Disclosed are processes and intermediate compounds for preparing dihydropteridinones of general formula (I) ##STR00001## wherein the groups L and...
US-8,138,340 Bicyclononene derivatives
The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical...
US-8,138,339 Inhibitors of protein kinases
The present invention is directed to 2-cycloalkylamino-4-arylamino-benzamide compounds of formula I pharmaceutically acceptable salts thereof which are...
US-8,138,338 Aurora kinase inhibitors from an encoded small molecule library
The present invention provides, at least in part, compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z.sub.1, Z.sub.2, Z.sub.3,...
US-8,138,337 Reverse-turn mimetics and method relating thereto
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their...
US-8,138,336 Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said...
US-8,138,335 Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient
A compound represented by formula (I) ##STR00001## wherein the symbols in the formula are the same meanings as those in specification, salts thereof,...
US-8,138,334 Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists
This invention concerns substituted oxa-diaza-spiro-[5.5]-undecanone derivatives having neurokinin antagonistic activity, in particular an NK.sub.1 antagonistic...
US-8,138,333 Sulfonyl-indole derivatives
The present invention relates to novel compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as described...
US-8,138,332 Synthesis of cyclen derivatives
The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic...
US-8,138,331 Water-dispersible polysaccharide derivatives of reduced glyoxal content, and a process for decreasing the...
A description is given of glyoxal-treated polysaccharide derivatives which, to decrease the unbound glyoxal, are treated with an aqueous solution of one or more...
US-8,138,330 Process for the synthesis of oligonucleotides
The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the...
US-8,138,329 siRNA targeting connective tissue growth factor (CTGF)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize...
US-8,138,328 Modulation of apolipoprotein (A) expression
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to...
US-8,138,327 Inducible systems and methods for controlling siRNA expression
An inducible system and methods for controlling expression of siRNA are provided. An inducible system for producing siRNA only in the presence of HIV TAT, and...
US-8,138,326 Method and kit for quantitative and qualitative determination of human papillomavirus
The present invention relates to a method and kit for quantitative and qualitative determination of human papillomavirus, HPV, in a sample. More precisely, for...
US-8,138,325 Promoter variants for expressing genes in a fungal cell
The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the...
US-8,138,324 Expression system for proteins
The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic...
US-8,138,323 Isolated cDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and...
An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve...
US-8,138,322 Human T1R2 nucleic acid sequences and polypeptides
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of...
US-8,138,321 Acetolactate synthase (ALS) selectable marker from Trichoderma reesei
A nucleic acid encoding an acetolactate synthase (ALS) protein that provides resistance to ALS inhibitors, e.g., sulphonylurea and imidazolinone compounds, is...
US-8,138,320 Fluorescent proteins and methods for using same
The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from Entacmaea quadricolor and mutants thereof. Also of interest...
US-8,138,319 Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
The present invention provides an aptamer or pool of aptamers (nucleic acid sequences) that bind(s) to a target molecule on the surface, accessible from the...
US-8,138,318 Hepatitis B pre-S2 nucleic acid
This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a...
US-8,138,317 Purification of pegylated polypeptides
The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation...
US-8,138,316 Feline pancreatic lipase
Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments...
US-8,138,315 Anti-alpha V immunoliposome compositions, methods and uses
An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one...
US-8,138,314 Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations
The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J.alpha.Q.sup.+ T cells, and the...
US-8,138,313 Treatment of tumors using specific anti-L1 antibody
The present invention relates to the anti-L1 monoclonal antibody 9.3 as well as to related antibodies or binding molecules and well as to the uses thereof,...
US-8,138,312 Compositions for regulation of tumor necrosis factor-alpha
The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor...
US-8,138,311 Modified proteins, designer toxins, and methods of making thereof
The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as...
US-8,138,310 Chimeric CD154 polypeptides
The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an...
US-8,138,309 Modified rubisco large subunit n-methyltransferase useful for targeting molecules to the active-site vicinity...
The present invention generally relates to a modified Rubisco large subunit .sup..epsilon.N-Methyltransferase (Rubisco LSMT, or RLSMT). The present invention...
US-8,138,308 Modified peptide substrate
The invention provides novel reagents and methodologies for detecting free versus bound compounds. It is particularly useful to detect thrombin when it is not...
US-8,138,307 Parkin interacting polypeptides and methods of use
The invention provides parkin binding polypeptides and encoding nucleic acids. The invention also provides antibodies specific for the parkin binding...
US-8,138,306 Separation method
The present invention relates to a method of separating a compound from a liquid, which method comprises providing a separation matrix comprising at least one...
US-8,138,305 Analogues of GLP-1
The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such...
US-8,138,304 Neural regeneration peptides and formulations thereof
Neural regeneration peptide consisting of a sequence comprised in the sequence of REGRRAAPGRAGG(SEQ ID NO:1).
US-8,138,303 Polymers
The present invention relates to novel polymers comprising a repeating unit of the formula (I) and their use in electronic devices. The polymers according to...
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