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Patent # Description
US-8,138,201 Treatment of progressive neurodegenerative disease with ibudilast
Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast ...
US-8,138,200 Compositions and methods for double-targeting virus infections and targeting cancer cells
The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at...
US-8,138,199 Use of bi-aryl meta-pyrimidine inhibitors of kinases
The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting...
US-8,138,198 Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y have defined meanings, having histone...
US-8,138,197 Spirochromanon derivatives
The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of...
US-8,138,196 Antifungal wallboards and building materials and methods for the production thereof
The present invention relates to, inter alia, methods for the treatment of wallboards and the treated wallboards. In particular, the invention relates to the...
US-8,138,195 Inhibitors of human phosphatidylinositol 3-kinase delta
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and...
US-8,138,194 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors
Fused bicyclic pyrimidine compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.3, R.sub.4, X.sub.1, X.sub.2, Y, Z, A, B, C, D, n, and the two bonds...
US-8,138,193 Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
Novel fused pyrazine compounds are disclosed that have a formula represented by the following: ##STR00001## with Z, R.sup.1, R.sup.2, R.sup.8 and R.sup.9 as...
US-8,138,192 Injectable meclizine formulations and methods
Methods of treating or preventing a vertigo, nausea, or vomiting condition comprising injecting a subject with a pharmaceutically acceptable formulation...
US-8,138,191 Inhibitor compounds and cancer treatment methods
A synergistically effective combination of an anti-cancer agent and a therapeutic compound, such as an mTOR-Rictor complex inhibitor, a Serine 473...
US-8,138,190 Diaza heterocyclic amide compounds and their uses
Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related...
US-8,138,189 Substituted benzene compounds as modulators of the glucocorticoid receptor
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and...
US-8,138,188 Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) ##STR00001## wherein the variables and substituents are as...
US-8,138,187 Substituted heteroaryl derivatives
The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of...
US-8,138,186 Pyrazole derivatives as sigma receptors antagonists
The present invention relates to compounds of formula (I), ##STR00001## methods for their preparation, medicaments comprising these compounds as well their use...
US-8,138,185 Urea glucokinase activators
This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of...
US-8,138,184 Isoxazole derivatives and pharmaceutical compositions comprising the same
An isoxazole derivative is provided. The isoxazole derivative has following formula: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5,...
US-8,138,183 Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K
A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their...
US-8,138,182 Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the...
US-8,138,181 Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
Compounds of Formula I: in which A, B, R.sup.1, R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5 R.sup.6, R.sup.7 and R.sup.8 have the meanings given in the...
US-8,138,180 Exo-selective synthesis of himbacine analogs
This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by...
US-8,138,179 Spiro-imidazo compounds
Novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R.sup.1, R.sup.1', Q, m...
US-8,138,178 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
Disclosed is a compound represented by Formula (Im.sup.1) ##STR00001## or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Also...
US-8,138,177 Benzimidazolone derivatives as CB2 receptor ligands
This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R.sup.1, R.sup.2 and R.sup.3 are each as...
US-8,138,176 Imidazo compounds
Heterocyclic compounds of the formula (I) and salts, preferably pharmaceutically acceptable salts thereof, are provided in which R, R.sup.1, R.sup.2, Q, m and n...
US-8,138,175 Heterocyclyl compounds
The invention is concerned with novel heterocyclyl compounds of formula (I): ##STR00001## wherein A, X, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
US-8,138,174 Compounds with a combination of cannabinoid CB.sub.1 antagonism and serotonin reuptake inhibition
Compounds with a combination of cannabinoid CB.sub.1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds,...
US-8,138,173 Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods
Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical...
US-8,138,172 8-oxoadenine derivatives acting as modulators of TLR7
The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy....
US-8,138,171 Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
US-8,138,170 Immunosuppressive Ningalin compounds
The present invention provides compositions and methods comprising ningalins for use in modulating immune responses to infection, injury, allergy and/or...
US-8,138,169 Combination therapy for bipolar disorder
Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are...
US-8,138,168 Renin inhibitors
The invention relates to compounds having the formulae: ##STR00001## wherein the variables are as defined herein. The invention further relates to methods of...
US-8,138,167 Methods for treating lung cancers
The present invention provided methods for treating lung cancers using therapeutic agents for lung cancers comprising erbB receptor inhibitors as active...
US-8,138,166 Method to induce fatty liver in animal
The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and...
US-8,138,165 Chromones and chromone derivatives and uses thereof
Certain 2- and/or 3-substituted 5,6,7 substituted chromones are of use in treatment of treating diseases associated with overproduction of TNF-.alpha., diseases...
US-8,138,164 HCV NS3 protease inhibitors
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their...
US-8,138,163 Aldehyde conjugated flavonoid preparations
There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer...
US-8,138,162 Natural sweetener
The invention relates to extracts, in particular non-nutrient phytochemicals, form sugar cane or sugar beet waste products, such as molasses, sugar mud and...
US-8,138,161 Modified small interfering RNA molecules and methods of use
The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also...
US-8,138,160 Reagents, methods and systems to suppress pro-inflammatory cytokines
The present invention relates to reagents, methods and systems to treat inflammation and pain in a subject using small interfering RNA (siRNA) molecules...
US-8,138,159 Composition for inhibiting function of human Flt3
To provide a means of controlling the function of Flt3. A composition for inhibiting the function of human Flt3, a method of inducing apoptosis by using the...
US-8,138,158 Compositions and methods for therapy for diseases characterized by defective chloride transport
Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The...
US-8,138,157 Antibiotic formulation and method of treatment
A formulation comprised of particles which may be in groups and are comprised of a biocompatible polymer and an antimicrobial drug for controlled release of the...
US-8,138,156 Ophthalmic compositions containing diglycine
Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the...
US-8,138,155 Compounds for intracellular delivery of therapeutic moieties to nerve cells
A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent...
US-8,138,154 Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of...
US-8,138,153 Potassium channel modulator peptide
A novel 13-residue peptide Mo1659 is isolated from the venom of a the cone snail, Conus monile. HPLC fractions of the venom extract yielded an intense UV...
US-8,138,152 Methods of treatment using WISP polypeptides
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous...
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