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Patent # Description
US-8,137,950 Bacteriophage resistant lactic acid bacteria
A lactic acid bacterium (LAB) wherein an YjaE protein is essentially inactive and the LAB thereby get improved resistance to bacteriophages, a starter culture...
US-8,137,949 Biosynthesis of commodity chemicals
Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting suitable monosaccharides or oligosaccharides, such as those...
US-8,137,948 Methods for producing preparations of recombinant AAV virions substantially free of empty capsids
Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography...
US-8,137,947 Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by...
The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other...
US-8,137,946 Recombinant GRAS strains expressing thermophilic arabinose isomerase as an active form and method of preparing...
The present invention relates to a recombinant GRAS (Generally Recognized As Safe) strains expressing thermophilic arabinose isomerase as an active form and...
US-8,137,945 Thermostable cellulase having increased enzyme activity
A thermostable cellulase having increased enzyme activity is disclosed. The cellulase comprises a modified amino acid sequence of SEQ ID NO: 2, wherein the...
US-8,137,944 Modified amylases from pseudomonas species, methods of making and uses thereof
Variant polypeptides derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the variant polypeptides comprise an amino acid...
US-8,137,943 Heat-resistant DNA ligase with high reactivity
Thermostable DNA ligases with enhanced DNA binding activity and reaction activity are obtained. These modified thermostable DNA ligases having enhanced DNA...
US-8,137,942 Method of preparing a modified surface
Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density...
US-8,137,941 Chondroitin polymerase and DNA encoding the same
A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and...
US-8,137,940 Method for production of biomass using a gluconobacter oxydans comprising an inactivated NADP dependent glucose...
The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as...
US-8,137,939 Method of recovering L-threonine from L-threonine fermentation broth using nonsolvent
Provided are a method of recovering L-threonine from the fermentation broth of an L-threonine producing microorganism, comprising: separating microbial bodies...
US-8,137,938 Method for producing an L-amino acid
An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so...
US-8,137,937 Method for bisulfite treatment
The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid via treatment of the...
US-8,137,936 Selected amplification of polynucleotides
The invention provides methods and compositions for selectively amplifying one or more target polynucleotides in a sample. In one aspect, a plurality of...
US-8,137,935 Method for isolating endotoxins
The invention concerns a novel method for extracting endotoxins from bacteria, and the use of said method for preparing compositions comprising endotoxins or...
US-8,137,934 Regeneration and neogenesis of retinal photoreceptor cell using Otx2 gene
The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2...
US-8,137,933 Mammalian expression vector pUHAB
The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS),...
US-8,137,932 Method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-EGP-2...
The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a...
US-8,137,931 Fusion proteins of HIV regulatory/accessory proteins
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or...
US-8,137,930 Attenuated Salmonella enterica serovar paratyphi A and uses thereof
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression...
US-8,137,929 Basic protein purification tags from thermophilic bacteria
The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for...
US-8,137,928 Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms
The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an...
US-8,137,927 Molded protein material in form of pellet for sensor
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and...
US-8,137,926 Kit for assaying EphA4 processing by gamma-secretase
The present invention provides a kit for assaying the processing of EphA4 by .gamma.-secretase.
US-8,137,925 Methods and compositions for protein labeling using lipoic acid ligases
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic...
US-8,137,924 Method and compositions for detecting botulinum neurotoxin
A molecular construct capable of fluorescent resonance energy transfer (FRET), comprising a linker peptide, a donor fluorophore moiety and an acceptor...
US-8,137,923 Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved...
US-8,137,922 Method for diagnosing the metabolic syndrome (MS)
The present invention discloses a method for diagnosing the metabolic syndrome by determination of the afamin content in a sample of a body fluid or a tissue...
US-8,137,921 Homogeneous time resolved fluorescence based test system for Paramyxoviridae
The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the RSV F1 six-helix...
US-8,137,920 Multi-wavelength analyses of sol-particle specific binding assays
The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the...
US-8,137,919 Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and...
A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by...
US-8,137,918 Sperm-specific cation channel, CatSper4, and uses therefor
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be...
US-8,137,917 Droplet actuator devices, systems, and methods
The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via...
US-8,137,916 Susceptibility gene for alzheimer's disease
The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of...
US-8,137,915 Genes involved in intestinal inflammatory diseases and use thereof
The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and...
US-8,137,914 Variants of alpha-fetoprotein coding and expression sequences
The invention discloses the sequences of variant forms of alpha-fetoprotein transcripts that have been identified in human hemopoietic progenitors but not in...
US-8,137,913 Methods for nucleic acid manipulation
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination...
US-8,137,912 Methods for the diagnosis of fetal abnormalities
The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention...
US-8,137,911 Preparation and use of single-stranded transcription substrates for synthesis of transcription products...
The present invention provides methods, compositions and kits for using an RNA polymerase for making transcription products corresponding to a target sequence...
US-8,137,910 Method of regulating gene expression
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs...
US-8,137,908 Mesothelin vaccines and model systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are...
US-8,137,907 Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof
This invention provides a genetically tractable in situ non-human animal model for hepatocellular carcinoma. The model is useful, inter alia, in understanding...
US-8,137,906 Method for the synthesis of DNA fragments
The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a)...
US-8,137,905 Apparatus and method for determining an analyte in a fluid
The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally...
US-8,137,904 Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or...
Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal,...
US-8,137,903 Method for magnetic separation of red blood cells from a patient sample
A method for separating components from a patient sample is provided. In particular, the present invention provides a method for the separation of red blood...
US-8,137,902 Method of manufacturing mechanical and micromechanical parts
A method of manufacturing parts of a first material able to be etched from a substrate including at least one superficial layer of the first material, includes...
US-8,137,901 Method for fabricating an image sensor
A method for fabricating an image sensor is disclosed. First, a semiconductor substrate is provided, in which a photosensitive region is defined on the...
US-8,137,900 Electrophoretic display device
An electrophoretic display device includes a multiplicity of individual reservoirs containing a display medium between conductive substrates, at least one of...
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