Nanoparticles for protein/peptide delivery and delivery means thereof
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or...
Biomimetic composition reinforced by a polyelectrolytic complex of
hyaluronic acid and chitosan
The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and...
Polyconjugates for in vivo delivery of polynucleotides
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian...
Immediate release and sustained release ibuprofen dosing regimen
A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage...
Drug delivery nanocarriers targeted by landscape phage
A targeted drug delivery nanocarrier and a method of forming the same is disclosed herein. The targeted drug delivery nanocarrier includes a plurality of...
Solid deodorizer for ostomy pouches
A solid deodorizer (14) for use on the inside surface (12) of an ostomy pouch (10). The solid deodorizer include a deodorizing mixture (24) and a carrier (16)...
Methods of increasing productivity in older sows while decreasing feed
The present invention provides methods for feeding older sows that beneficially reduce feed intake in older sows, yet improve pig survival and weaning weight of...
Taste titration therapies
The teachings provided herein generally relate to formulations, systems, and methods that have the ability to remit deficiencies and imbalances in a subject's...
Transplant/implant device and method for its production
A transplant/implant device for delivering at least one predetermined biologically active compound to a human or animal host system or for another biological...
Hydroxyphenyl cross-linked macromolecular network and applications thereof
A synthetic nucleus pulposus is provided that is useful in treatment of degenerative disc disease, augmentation of a degenerate disc, and alleviation of back...
4-aza-caprolactone-based polymeric compositions useful for the manufacture
of biodegradable medical devices and...
N-substituted 4-aza-caprolactone biodegradable polymers, including derivatives thereof, useful for making implantable medical devices and coatings therefore are...
Nonwoven tissue scaffold
A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus,...
Hyaluronic acid compound, hydrogel thereof and joint treating material
A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and...
Formulations of pharmacological agents, methods for the preparation
thereof and methods for the use thereof
In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble...
Process for the preparation of dispersions
The present invention relates to a process of a dispersion of an active substance or composition in a aqueous phase which comprises dispersing in an aqueous...
Isolated complexes of covalently cross-linked endotoxin and modified MD-2
Applicants have produced and isolated chemically cross-linked complexes of endotoxin and modified MD-2, and have developed methods of using these complexes.
Polyanionic polymer adjuvants for Haemophilus influenzae B saccharide
The present invention relates to the field of vaccines, and in particular vaccines comprising antigens of low isoelectric point at pH 7.0, in particular the...
Analysis of saccharide vaccines without interference
The invention is based on methods that allow analysis of mixed meningococcal saccharides from multiple serogroups even though they share monosaccharide units....
Immunogen adherence inhibitor directed to Lactobacillus organisms and
method of making and using it
A microbial adherence inhibitor specific to lactic acid producing microorganisms, in the form of fowl egg antibodies is disclosed, along with the method of...
Canine lyme disease vaccine
The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective...
Non-protein stabilized clostridial toxin pharmaceutical compositions
A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the...
Genetically engineered equine influenza virus and uses thereof
The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN)...
Bont/a peptides and methodsof predicting and reducing immunoresistance to
botulinum toxin therapy
The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual...
Compositions comprising HPV polypeptides and immunoenhancement peptides
for the treatment and prevention of...
The present invention relates to a fusion protein comprising a fusion polypeptide of E6 and E7 of a human papilloma virus, a signal peptide for secreting the...
Nucleic acids and proteins from Streptococcus groups A & B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid...
Immunostimulatory regimen comprising administering type 1 interferon and
agonistic anti-CD40 antibody
A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these...
This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The...
Method of identifying membrane IgE specific antibodies and use thereof for
targeting IgE producing precursor cells
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored IgE and which bind to these novel epitopes...
Elimination of heterogeneous or mixed cell population in tumors
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by...
Methods and compositions for generating human monoclonal antibodies
The present invention provides a method for generating human monoclonal antibodies, especially those that are specific for surface antigens representative of a...
Fully human antibodies against human 4-1BB
Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one...
Nattokinase for degrading and reducing amyloid fibrils--associated with
alzheimer's disease, prion diseases and...
A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence...
Systemic non-nodular endosymbiotic nitrogen fixation in plants
Non-leguminous crops, e.g. wheat, maize and rice, do not form nodules and are dependant for their nutrition on fixed nitrogen from the soil, or from...
Method and kit for repairing a defect in bone
Methods and devices are provided for the repair of bone defects. The bone defect repair may be accomplished by minimally invasive means. The bone defect repair...
Oncolytic virus therapy
A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition...
Proliferated cell lines and uses thereof
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing...
Controlled release interferon drug products and treatment of HCV
infections using same
The invention relates to controlled release formulations comprising a microparticle comprising a biodegradable polymer and one or more interferon compounds and...
Application of tannins to reduce odor emissions from animal waste
Quebracho tannins are effective for the treatment of animal wastes which contain feces or fecal waste-containing material to inhibit odor emissions therefrom....
Metal oxide composition
A composition comprises a non-ionic surfactant and hydrophobic particles of metal oxide having the mean length of the primary particles in the range from 50 to...
Tooth whitening compositions
A liquid, substantially anhydrous tooth whitener composition for delivery of a tooth-whitening amount of active whitening ingredient onto teeth, with effective...
Carrier particles for use in dry powder inhalers
In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles...
Method and apparatus for synthesis of [.sup.11C]phosgene using
concentrated [.sup.11C] carbon monoxide with UV...
Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled...
Production and conditioning of synthesis gas obtained from biomass
A method of producing and treating synthesis gas in which a biomass-rich material is gasified in a gasifier containing a fluidized bed at a temperature that...
Method of roasting material containing at least one of V, Mo and Ni and
rotary kiln for roasting the same
Provided is a roasting method capable of reducing both C and S components in minerals down to 0.5% or less, respectively, and securing a yield ratio of 90% or...
System and method for producing carbon nanotubes
A method of producing carbon nanotubes, comprising, in a reaction chamber: evaporating at least a partially melted electrode comprising a catalyst by an...
Sidewall-functionalized carbon nanotubes, and methods for making the same
The invention provides a method of functionalizing the sidewalls of a plurality of carbon nanotubes with oxygen moieties, the method comprising: exposing a...
Method for preparing hydrophobic aerogel and hydrophobic aerogel prepared
A method for preparing a silica aerogel in the form of permanently hydrophobic powder in a short time, wherein the silica aerogel has a high specific surface...
Nanoporous carbide derived carbon with tunable pore size
The present invention provides a method for producing a nanoporous carbide-derived carbon composition with a tunable pore structure and a narrow pore size. Also...
Systems and methods for removing gaseous pollutants from a gas stream
Horizontal gas-liquid scrubbing systems and associated gas scrubbing methodologies are provided. In one embodiment, a horizontal duct scrubbing system includes...
Diesel engine exhaust treatment system and method including a platinum
group metal trapping device
A diesel engine exhaust treatment system and method is provided which includes a platinum group metal trapping device (16) comprising cerium oxide or a...