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Patent # Description
US-8,143,455 Process for preparing 2-hydroxyacetals and the corresponding 2-hydroxyalkanals
What is described is a process for preparing 2-hydroxyacetals of the general formula in which R.sup.1 is hydrogen, a branched or unbranched ...
US-8,143,454 Method for synthesis of acrolein from glycerol
The invention provides a technology for producing acrolein from glycerol while maintaining high reagent partial pressures, which leads to higher yield. The...
US-8,143,453 Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
.alpha.,.beta.-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: ##STR00001## wherein Ar.sup.1, Ar.sup.2, X, n, * and R are...
US-8,143,452 Salts having alkoxytris(fluoroalkyl)borate anions
The invention relates to salts having alkoxytris(fluoroalkyl)borate anions which on the one hand are used for the synthesis of ionic liquids, but on the other...
US-8,143,451 Methods of preparing tertiary carbinamine compounds
The present invention relates to a method for the preparation of tertiary carbinamine compounds from diastereoselective allylation and crotylation of...
US-8,143,450 Process for the preparation of derivatives of tetraaminobenzene
A process is provided for preparing complexes of 1,2,4,5-tetraminobenzene with an aromatic diacid. The process design eliminates costly intermediate drying and...
US-8,143,449 Process for the synthesis of agomelatine
Process for the industrial synthesis of the compound of formula (I) ##STR00001##
US-8,143,448 Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives
The present invention relates to a process for the preparation of (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamides as well as novel compounds prepared or used...
US-8,143,447 Treatment of cancer
The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides...
US-8,143,446 Substituted acrylamide derivative and pharmaceutical composition comprising the same
A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: ##STR00001## ...
US-8,143,445 HDAC inhibitors
This invention provides the compound having the structure ##STR00001## wherein n is 1-10; X is C--R.sub.11 or N, wherein R.sub.11 is H, OH, SH, F, Cl,...
US-8,143,444 Recovery of organic acids
A method is disclosed for the recovery of an organic acid from a dilute salt solution in which the cation of the salt forms an insoluble carbonate salt. An...
US-8,143,443 Process for preparing gabapentin
A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile;...
US-8,143,442 Preparation for a cyclohexanecarboxylic acid derivative and intermediates
A process for the preparation of a compound of formula (Ia): ##STR00001## which are useful as intermediates in the preparation of i.a. pharmaceutically active...
US-8,143,441 Deeply reduced oxidation catalyst and its use in preparing N-(phosphonomethyl) glycine compounds
This invention relates to an improved catalyst, comprising a carbon support having a noble metal at its surface, for use in catalyzing liquid phase oxidation...
US-8,143,440 Method for separation of olefin-alcohol azeotropic mixture
There is provided a method for separating and collecting at least alcohol with a high purity from an azeotropic mixture of olefin and alcohol. The method...
US-8,143,439 Zeolite-catalyzed preparation of alpha-hydroxy carboxylic acids and esters thereof
A process for the production of lactic acid and 2-hydroxy-3-butenoic acid or esters thereof by conversion of glucose, fructose, sucrose, xylose and ...
US-8,143,438 Hydrogenation processes
The present invention is directed to a process for hydrogenating one or more organic compounds especially unsaturated organic compounds by bringing the compound...
US-8,143,437 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds...
US-8,143,436 Process for preparing alkyl alkoxybenzoates in one step
Process for preparing a compound of the formula ##STR00001## by contacting, in an organic solvent in the presence of an aqueous solution of a base, hydroxy...
US-8,143,435 One pot process for the preparation of candesartan
Present invention is to provide one pot synthesis of candesartan without isolating the ester intermediate.
US-8,143,434 Production by distillation of acetone cyanhydrin and method for producing methacrylic ester and subsequent products
The present invention relates in general terms to a process for preparing acetone cyanohydrin, comprising as steps: A. contacting acetone and hydrocyanic acid...
US-8,143,433 Low triphenylphosphate, high phosphorous content isopropyl phenyl phosphates with high ortho alkylation
The present invention relates to low triphenyl phosphate, high phosphorous content aryl phosphates with high ortho alkylation that are suitable for use as flame...
US-8,143,432 Process for regioselective mono-tosylation of diols
The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present...
US-8,143,431 Low temperature thermal conductive inks
Novel copper alkoxide compound based ink formulations and their chemical syntheses are disclosed. The method of using the ink formulations to print conducting...
US-8,143,430 Nano-linked heteronuclear metallocene catalyst compositions and their polymer products
The present invention provides polymerization catalyst compositions employing novel heterodinuclear metallocene compounds. Methods for making these new...
US-8,143,429 Process for producing organic transition metal complex compound, metathesis catalyst produced by using the...
A process for synthesizing an organic transition metal complex compound with an atom group having an electron-donor ability, in an industrially and economically...
US-8,143,428 Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
Compounds of Formula I: ##STR00001## wherein R.sup.1, R.sup.2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for...
US-8,143,427 Method for producing aminoacetylpyrrolidinecarbonitrile derivative
It is to provide a method for efficiently producing an aminoacetylpyrrolidinecarbonitrile derivative which is useful as a DPP-IV inhibitor. It is a method for...
US-8,143,426 IAP inhibitors
Smac mimetics that inhibit IAPs.
US-8,143,425 Heterocyclic aromatic compounds useful as growth hormone secretagogues
Novel heterocyclic aromatic compounds are provided that are useful in stimulating endogenous production or release of growth hormone, said compounds having the...
US-8,143,424 Thyroid like compounds
A novel thyroid like compounds of formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Z are as defined in the specification, method for its preparation,...
US-8,143,423 N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids
A process for preparing hydroxamic acids is provided. The process comprises reacting an aldehyde with a nitroso compound in the presence of a N-heterocyclic...
US-8,143,422 Benzimidazole derivatives
The invention is concerned with novel benzimidazole derivatives of formula (I) ##STR00001## wherein R.sup.1 to R.sup.6 are as defined in the description and...
US-8,143,421 Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors
The present invention concerns the compounds having the formula ##STR00001## N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and...
US-8,143,420 Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof
Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and...
US-8,143,419 Trisubstituted 1,2,4-triazoles
The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them,...
US-8,143,418 Dimeric small molecule potentiators of apoptosis
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric...
US-8,143,417 Method for the preparation of zolmitriptan
In the preparation of zolmitriptan of formula III the reduction of the diazonium salt to (5)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one of formula IV is...
US-8,143,416 Alternative synthesis of renin inhibitors and intermediates thereof
The present invention relates to synthetic routes to prepare a compound of the formula ##STR00001## wherein R.sub.1 is halogen, C.sub.1-6halogenalkyl,...
US-8,143,415 Processes for making epothilone compounds and analogs
A process for making epi-epothilone compounds according to formula A.1, ##STR00001## by reacting a compound according formula C ##STR00002## with at least one...
US-8,143,414 Hepatitis C virus inhibitors
This disclosure concerns novel compounds of Formula (I) or Formula (II) as defined in the specification and compositions comprising such novel compounds. These...
US-8,143,413 Polycationized phospholipid derivatives
The present invention provides novel phospholipid derivatives. Furthermore, the present invention provides lipid membrane structures excellent in gene/nucleic...
US-8,143,412 Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs)
Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease...
US-8,143,411 Substituted 6-phenylnicotinic acids and their use
The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment...
US-8,143,410 Kinase inhibitors
The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal...
US-8,143,409 Crystalline form of rabeprazole sodium
Rabeprazole sodium in the monohydrate crystalline form, pharmaceutical compositions thereof, the use thereof in therapy, a process for its preparation, and the...
US-8,143,408 N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the...
The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in...
US-8,143,407 Process for production of heteroaryl-type boron compounds with iridium catalyst
The present invention provides an economically and industrially superior simple process that enables the selective production of an aromatic heterocyclic...
US-8,143,406 Process for the manufacture of HI-6 dimethanesulfonate
The invention provides a process for the manufacture of HI 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with...
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