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Patent # Description
US-8,143,405 Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
The present invention is directed to compounds of formula (I) ##STR00001## which are inhibitors of the beta-secretase enzyme and that are useful in the...
US-8,143,404 Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: ##STR00001## (wherein each symbol is as...
US-8,143,403 CGRP receptor antagonists
The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to...
US-8,143,402 Polymorphic forms of a macrocyclic inhibitor of HCV
Provided are crystalline forms of the compound of formula (I), which is a macrocyclic inhibitor of HCV, processes for the preparation thereof, and ...
US-8,143,400 Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine hydrochloride
An industrially acceptable process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine from a cis/trans mixture of...
US-8,143,399 Photosensitizer dye
A photosensitizer dye is provided. The photosensitizer dye is a ruthenium (Ru) complex represented by the following general formula (1). ##STR00001##
US-8,143,398 Activity of new N-acylated ciprofloxacin derivatives against faculative intracellular bacteria
Bartonella species are facultative intracellular pathogens responsible for a range of diseases in animals and in humans. A selection of N-acyl ciprofloxacin...
US-8,143,397 Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
The present invention relates to an improved process for preparation of Voriconazole and Voriconazole (1R)-(-)-10-camphorsulfonate.
US-8,143,396 1-[2', 3' -dideoxy-3' C- (hydroxymethyl)--beta-D-erythro-pentofuranosyl] cytosine derivatives as HIV inhibitors
Novel bicyclic tetrahydrofuran compounds and derivatives, and pharmaceutically acceptable salts thereof, according to the formula: ##STR00001## These compounds...
US-8,143,395 Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines
5-Substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines are manufactured from 2-substituted-4-amino-5-methoxypyrimidines in a process that avoids...
US-8,143,394 Pyrido(3,2-d)pyrimidines useful for treating viral infections
2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or...
US-8,143,393 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases...
This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or...
US-8,143,392 Method for the extraction of starch from corn
A method of extracting starch from corn. The method comprises steeping ground corn in a mixture of ammonium hydroxide and water, for a period of between 45...
US-8,143,391 Process for producing water-soluble hyaluronic acid modification
The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a...
US-8,143,390 Compositions and methods for inhibiting expression of anti-apoptotic genes
The present invention relates to an isolated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of bcl-2, where the antisense strand...
US-8,143,389 Inhibiton of metallo-.beta.-lactamase by double-stranded DNA
Compositions and methods for identifying double stranded DNA molecules that bind with high affinity to metallo-.beta.-lactamase. Methods for inhibiting the...
US-8,143,388 Method and test kit for quantitative determination of polynucleotides in a mixture
The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The...
US-8,143,387 Engineered antibody-stress protein fusions
Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic,...
US-8,143,386 Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins...
US-8,143,385 Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R)....
US-8,143,384 Mutation of PRPS1 gene causing CMTX5 disease and the use thereof
Disclosed is a gene mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy. More specifically, disclosed...
US-8,143,383 .DELTA.-6 desaturase and uses thereof
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., ...
US-8,143,382 Pyrazole disazo dye and ink containing the dye
The invention provides a specific pyrazole disazo dye which is a yellow dye having excellent solubility in nonpolar solvents, in particular, hydrocarbon...
US-8,143,381 Use of ionic liquids for membrane protein extraction
The present invention relates to the use of ionic liquids or of mixtures comprising at least one ionic liquid and at least one further solvent for the...
US-8,143,380 Therapeutic peptides
The invention relates to compounds that exhibit improved bioefficacy in multidose administration. More specifically, the invention relates to polypeptides or...
US-8,143,379 Human monoclonal antibodies to CTLA-4
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4)....
US-8,143,378 Polymer factor VIII moiety conjugates
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a...
US-8,143,377 Muscle lamin A/C interacting protein, gene encoding same, and uses therefor
Peptide sequences of human and murine muscle lamin A/C interacting protein and nucleotide sequences encoding same and are provided. Uses of the muscle lamin A/C...
US-8,143,376 High affinity NY-ESO T cell receptor
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being...
US-8,143,375 Aziridine aldehydes, aziridine-conjugated amino derivatives, aziridine-conjugated biomolecules and processes...
The present invention relates to unprotected amino aldehydes and applications for same. More particularly, the present invention relates to novel aziridine...
US-8,143,374 Polypeptide derivatives of parathyroid hormone (PTH)
The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as...
US-8,143,373 Carbohydrate-containing pan cancer marker
The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be...
US-8,143,372 Synthetic regulators of ferritin protein nanocage pores and methods of use thereof
The present invention provides synthetic regulators of ferritin pores, and compositions comprising the regulators. The regulators function to reduce ferritin...
US-8,143,371 Preparation of polytrimethylene ether glycol or copolymers thereof
This invention relates to a process for preparing polytrimethylene ether glycols or copolymers thereof having a number-average molecular weight of at least...
US-8,143,370 One-part moisture curable sealant and method of making the same
One-part moisture curable sealant compositions and methods of making the same are provided. The composition includes a silane-terminated polythioether component...
US-8,143,369 Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds...
US-8,143,368 Disposable medical supplies from hydrolytically biodegradable plastics
Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes,...
US-8,143,367 Method for the esterification of terephtalic acid with butanediol, method for the manufacture of polybutylene...
The present invention relates to an improved method for the esterification of terephthalic acid with 1,4-butanediol, an improved method for the manufacture of...
US-8,143,366 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same
The present invention provides a compound having a formula: where R.sup.1 is selected from the group consisting of alkyl, CH.sub.2(OC.sub.2H.sub.4)OCH.sub.3,...
US-8,143,365 Formulations for reaction injection molding and for spray systems
This invention provides articles made by reaction injection molding and spray coatings, and processes for forming such articles and coatings. The coatings and...
US-8,143,364 Composition made from a diisocyanate and a monoamine and process for preparing it
Process for preparing a composition by reacting a polyisocyanate, a monoalkoxy polyoxyalkylene monoamine and water. The composition and its use in making...
US-8,143,363 Polymerizable composition
The present invention relates to a polymerizable composition comprising, as a component A, at least one silicon-organic compound having at least two...
US-8,143,362 Composition containing unsaturated silicone compounds, dental materials containing them and use thereof
The invention relates to a curable composition comprising addition curable silicone component (A) having a linear siloxane backbone at least one unsaturated,...
US-8,143,361 EVM in solar modules
The present invention relates to a solar module containing at least one layer made up of at least one .alpha.-olefin-vinyl acetate copolymer which has a vinyl...
US-8,143,360 Aqueous developable benzocyclobutene-based polymer composition and method of use of such compositions
The invention is a composition comprising a curable arylcyclobutene based oligomer or polymer and a dissolution inhibitor which comprises a compound comprising...
US-8,143,359 Organic silicone compound
The purpose of the present invention is to provide an organic silicon compound which has a vinyl group more reactive than those of the conventional organic...
US-8,143,358 Installation for gas-phase polymerisation
Installation for the gas-phase polymerization of at least one olefinic monomer, comprising a horizontal stirred reactor (1) consisting of an undivided space,...
US-8,143,357 Phosphorus-containing compounds useful for making halogen-free, ignition-resistant polymers
Phosphorus-containing compounds useful for flame retardant epoxy resins are disclosed. The flame retardant epoxy resins may be used to make electrical...
US-8,143,356 Polyester resin composition, process for producing the same and molding thereof
A method for producing a polyester resin composition C), which comprises melt-kneading a polyester resin (A) which satisfies the following formulae (1), (2) and...
US-8,143,355 Polymer compound and method of synthesizing the same
Provided is a polymer compound having a furan ring having a degree of polymerization of 185 or more and 600 or less. This polymer compound has excellent...
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