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Patent # Description
US-8,143,304 (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives
The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R.sup.1, R.sup.2, R.sup.3,...
US-8,143,303 Carbazole derivatives as functional 5-HT.sub.6 ligands
Carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT.sub.6 receptor are described. The...
US-8,143,302 Methods and compositions for diagnostic and therapeutic targeting of COX-2
The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also...
US-8,143,301 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-8,143,300 Inhibitors of cellular necrosis
The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and...
US-8,143,299 Anti-mitotic anti-proliferative compounds
Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a...
US-8,143,298 Dual-acting antihypertensive agents
The invention is directed to compounds of formula I: ##STR00001## wherein Ar, r, R.sup.3, X, and R.sup.5-7 are as defined in the specification, and...
US-8,143,297 Heterocyclic derivatives as modulators of ion channels
The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable...
US-8,143,296 Thiazole-based compound and inhibitor of T-type calcium channel containing the same
The present invention relates to novel thiazole-based compounds and T-type calcium channel inhibitors containing the compound. The T-type calcium channel...
US-8,143,295 Compounds having activity in correcting mutant-CFTR processing and uses thereof
The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or...
US-8,143,294 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors
The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof.
US-8,143,293 Kinase inhibitors useful for the treatment of myleoprolific diseases and other proliferative diseases
Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant,...
US-8,143,292 N-Thio-anthranilamid compounds and their use as pesticides
N-Thio-anthranilamid compounds of formula (I) ##STR00001## wherein A is a group selected from A.sup.1 and A.sup.2 ##STR00002## wherein the variables and the...
US-8,143,291 Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological...
The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1-phosphate agonists or antagonists. As such, the...
US-8,143,290 Chemical compounds 572
Compounds of formula (I): ##STR00001## The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising...
US-8,143,289 Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme...
US-8,143,288 Inhibitors of HCV replication
Compounds having the structure of formula I are described. ##STR00001## The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can...
US-8,143,287 Thrombopoietin mimetics
The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic...
US-8,143,286 Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione)
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of...
US-8,143,285 Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said...
US-8,143,284 Poly(ADP-ribose)polymerase inhibitors
Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds...
US-8,143,283 Methods for treating blood-born tumors with thalidomide
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as...
US-8,143,282 Heterocyclic compounds
The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic...
US-8,143,281 Indoles
The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor...
US-8,143,280 Glucocorticoid receptor antagonists
The present invention relates to compounds of formula I ##STR00001## wherein A, n, R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the...
US-8,143,279 Benzimidazole-carboxamide compounds as 5-HT.sub.4 receptor agonists
The invention relates to benzimidazole-carboxamide 5-HT.sub.4 receptor agonist compounds of formula (I) ##STR00001## wherein R.sup.1 and X are as defined in...
US-8,143,278 Organic compounds
The present invention provides a compound of formula I: ##STR00001## said compound is inhibitor of aldosterone synthase, and/or 11beta-hydroxylase (CYP11B1),...
US-8,143,277 Method of using compounds having .beta..sub.2 adrenergic receptor agonist and muscarinic receptor antagonist...
This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8a, R.sup.8b, W,...
US-8,143,276 4-thio substituted quinoline and naphthyridine compounds
The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to...
US-8,143,275 Use of triazolopyrimidine derivatives as microbicides
Use of compounds of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the description for protecting engineered...
US-8,143,274 1-(2H)-isoquinolone derivative
The present invention provides: a compound represented by the following formula (I): ##STR00001## [wherein Y.sup.1 and Y.sup.4 represent a hydrogen atom or a...
US-8,143,273 Quinolizidine and indolizidine derivatives
The present invention relates to a compound of formula I-A or I-B ##STR00001## wherein X, R.sup.1, R.sup.2 and R.sup.3 are defined herein; or to a...
US-8,143,272 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the...
US-8,143,271 Compounds and methods for kinase modulation, and indications therefor
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity...
US-8,143,270 2-amino 1H-in-imidazo ring systems and methods
1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with...
US-8,143,269 Inhibitors of store operated calcium release
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels....
US-8,143,268 Bicyclic pyrimidinones and uses thereof
The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of...
US-8,143,267 Analgesic combination of oxycodone and nimesulide
Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or...
US-8,143,266 Aryl heterocyclic CGRP receptor antagonists
Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, B, m, n, J, X, R.sup.4, G.sup.1, G.sup.2, G.sup.3 and Y are as described herein)...
US-8,143,265 Method of treating atherosclerosis
A method of treating atherosclerosis in a subject is carried out by administering the subject 2-aminopurine or a pharmaceutically salt thereof in a treatment...
US-8,143,264 Xanthine derivatives as selective HM74A agonists
The present invention relates to a xanthine compound derivative which is 3-butyl-8-chloro-1-(3-{5-[(4-fluorophenyl)methyl]-2H-tetrazol-2-yl}propyl- ...
US-8,143,263 Therapeutic agents
A compound of Formula (I): ##STR00001## is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK),...
US-8,143,262 7-(3',4'-Dialkoxyphenyl)[1,2,4]-triazolo[1,5-A]pyrimidine compounds, process for preparing thereof, and...
The present invention relates to novel {7-(3',4'-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a...
US-8,143,261 Thiazolo (4,5-D) pyrimidine compounds
The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes and intermediates...
US-8,143,260 Tricyclic amine compound
A compound represented by the following general formula (I): ##STR00001## [wherein R.sup.1 represents hydrogen atom or a C.sub.1-6 alkyl group, A and B...
US-8,143,259 Cold menthol receptor antagonists
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are...
US-8,143,258 Benzothiazole compounds useful for Raf inhibition
Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula ##STR00001## wherein each symbol is...
US-8,143,257 Substituted phenols as active agents inhibiting VEGF production
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods,...
US-8,143,256 Cyclic amide and ester pyrazinoylguanidine sodium channel blockers
The present invention provides compounds represented by formula (I): ##STR00001## where the structural variables are defined herein. The compound of the...
US-8,143,255 Heteroalkyl linked pyrimidine derivatives
The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to...
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