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| Patent # | Description |
|---|---|
| US-8,143,304 |
(3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R.sup.1, R.sup.2, R.sup.3,... |
| US-8,143,303 |
Carbazole derivatives as functional 5-HT.sub.6 ligands Carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT.sub.6 receptor are described. The... |
| US-8,143,302 |
Methods and compositions for diagnostic and therapeutic targeting of COX-2 The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also... |
| US-8,143,301 |
Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical... |
| US-8,143,300 |
Inhibitors of cellular necrosis The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and... |
| US-8,143,299 |
Anti-mitotic anti-proliferative compounds Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a... |
| US-8,143,298 |
Dual-acting antihypertensive agents The invention is directed to compounds of formula I: ##STR00001## wherein Ar, r, R.sup.3, X, and R.sup.5-7 are as defined in the specification, and... |
| US-8,143,297 |
Heterocyclic derivatives as modulators of ion channels The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable... |
| US-8,143,296 |
Thiazole-based compound and inhibitor of T-type calcium channel containing
the same The present invention relates to novel thiazole-based compounds and T-type calcium channel inhibitors containing the compound. The T-type calcium channel... |
| US-8,143,295 |
Compounds having activity in correcting mutant-CFTR processing and uses
thereof The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or... |
| US-8,143,294 |
2-sulfanyl-substituted imidazole derivatives and their use as cytokine
inhibitors The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof. |
| US-8,143,293 |
Kinase inhibitors useful for the treatment of myleoprolific diseases and
other proliferative diseases Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant,... |
| US-8,143,292 |
N-Thio-anthranilamid compounds and their use as pesticides N-Thio-anthranilamid compounds of formula (I) ##STR00001## wherein A is a group selected from A.sup.1 and A.sup.2 ##STR00002## wherein the variables and the... |
| US-8,143,291 |
Indole compounds bearing aryl or heteroaryl groups having
sphingosine-1-phosphate (S1P) receptor biological... The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1-phosphate agonists or antagonists. As such, the... |
| US-8,143,290 |
Chemical compounds 572 Compounds of formula (I): ##STR00001## The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising... |
| US-8,143,289 |
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the
treatment or prevention of diabetes The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme... |
| US-8,143,288 |
Inhibitors of HCV replication Compounds having the structure of formula I are described. ##STR00001## The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can... |
| US-8,143,287 |
Thrombopoietin mimetics The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic... |
| US-8,143,286 |
Polymorphic forms of 3-(4-amino-1-oxo-1,3
dihydro-isoindol-2-yl)-piperidine-2,6-dione) Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of... |
| US-8,143,285 |
Indolecarboxylic acid derivative having PGD2 receptor antagonistic
activity The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said... |
| US-8,143,284 |
Poly(ADP-ribose)polymerase inhibitors Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds... |
| US-8,143,283 |
Methods for treating blood-born tumors with thalidomide The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as... |
| US-8,143,282 |
Heterocyclic compounds The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic... |
| US-8,143,281 |
Indoles The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor... |
| US-8,143,280 |
Glucocorticoid receptor antagonists The present invention relates to compounds of formula I ##STR00001## wherein A, n, R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the... |
| US-8,143,279 |
Benzimidazole-carboxamide compounds as 5-HT.sub.4 receptor agonists The invention relates to benzimidazole-carboxamide 5-HT.sub.4 receptor agonist compounds of formula (I) ##STR00001## wherein R.sup.1 and X are as defined in... |
| US-8,143,278 |
Organic compounds The present invention provides a compound of formula I: ##STR00001## said compound is inhibitor of aldosterone synthase, and/or 11beta-hydroxylase (CYP11B1),... |
| US-8,143,277 |
Method of using compounds having .beta..sub.2 adrenergic receptor agonist
and muscarinic receptor antagonist... This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8a, R.sup.8b, W,... |
| US-8,143,276 |
4-thio substituted quinoline and naphthyridine compounds The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to... |
| US-8,143,275 |
Use of triazolopyrimidine derivatives as microbicides Use of compounds of the formula (I) ##STR00001## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the description for protecting engineered... |
| US-8,143,274 |
1-(2H)-isoquinolone derivative The present invention provides: a compound represented by the following formula (I): ##STR00001## [wherein Y.sup.1 and Y.sup.4 represent a hydrogen atom or a... |
| US-8,143,273 |
Quinolizidine and indolizidine derivatives The present invention relates to a compound of formula I-A or I-B ##STR00001## wherein X, R.sup.1, R.sup.2 and R.sup.3 are defined herein; or to a... |
| US-8,143,272 |
3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the... |
| US-8,143,271 |
Compounds and methods for kinase modulation, and indications therefor Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity... |
| US-8,143,270 |
2-amino 1H-in-imidazo ring systems and methods 1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with... |
| US-8,143,269 |
Inhibitors of store operated calcium release Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels.... |
| US-8,143,268 |
Bicyclic pyrimidinones and uses thereof The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of... |
| US-8,143,267 |
Analgesic combination of oxycodone and nimesulide Disclosed is a pharmaceutical composition, comprising two analgesic compounds and/or pharmaceutically acceptable salts thereof consisting of nimesulide and/or... |
| US-8,143,266 |
Aryl heterocyclic CGRP receptor antagonists Compounds of formula I: ##STR00001## (wherein variables A.sup.1, A.sup.2, B, m, n, J, X, R.sup.4, G.sup.1, G.sup.2, G.sup.3 and Y are as described herein)... |
| US-8,143,265 |
Method of treating atherosclerosis A method of treating atherosclerosis in a subject is carried out by administering the subject 2-aminopurine or a pharmaceutically salt thereof in a treatment... |
| US-8,143,264 |
Xanthine derivatives as selective HM74A agonists The present invention relates to a xanthine compound derivative which is 3-butyl-8-chloro-1-(3-{5-[(4-fluorophenyl)methyl]-2H-tetrazol-2-yl}propyl- ... |
| US-8,143,263 |
Therapeutic agents A compound of Formula (I): ##STR00001## is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK),... |
| US-8,143,262 |
7-(3',4'-Dialkoxyphenyl)[1,2,4]-triazolo[1,5-A]pyrimidine compounds,
process for preparing thereof, and... The present invention relates to novel {7-(3',4'-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a... |
| US-8,143,261 |
Thiazolo (4,5-D) pyrimidine compounds The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes and intermediates... |
| US-8,143,260 |
Tricyclic amine compound A compound represented by the following general formula (I): ##STR00001## [wherein R.sup.1 represents hydrogen atom or a C.sub.1-6 alkyl group, A and B... |
| US-8,143,259 |
Cold menthol receptor antagonists Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are... |
| US-8,143,258 |
Benzothiazole compounds useful for Raf inhibition Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula ##STR00001## wherein each symbol is... |
| US-8,143,257 |
Substituted phenols as active agents inhibiting VEGF production The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods,... |
| US-8,143,256 |
Cyclic amide and ester pyrazinoylguanidine sodium channel blockers The present invention provides compounds represented by formula (I): ##STR00001## where the structural variables are defined herein. The compound of the... |
| US-8,143,255 |
Heteroalkyl linked pyrimidine derivatives The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to... |
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