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Patent # Description
US-8,143,254 Methods for modulating ion channels
In one embodiment, the invention provides an ion having the formula: (I) In another embodiment, the invention provides a method for modulating potassium,...
US-8,143,253 Organic compounds
Compounds of formula I ##STR00001## in free or salt or solvate form, where R1, R2 and R5 have the meanings as indicated in the specification, are useful for...
US-8,143,252 Tetrahalogenated compounds useful as inhibitors of angiogenesis
Methods for inhibiting a neoplasm in a subject and methods of inhibiting undesired angiogenesis that include administering to a subject a therapeutically...
US-8,143,251 Triazolotriazines as kinase inhibitors
The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as...
US-8,143,250 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders
In view of the great potential the quinazoline class of compounds offer, we started the synthesis and screening of a large number of new chemical entities with...
US-8,143,249 Prodrugs of A.sub.2B adenosine receptor antagonists
Disclosed are prodrugs of A.sub.2B adenosine receptor antagonists of the formula: ##STR00001## wherein R.sup.1 and R.sup.2 are independently lower alkyl;...
US-8,143,248 Tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and...
The invention concerns tricyclic N-heteroarylcarboxamide derivatives containing a benzimidazole unit of general formula (I): ##STR00001## Wherein A, P, Y,...
US-8,143,247 Combinations for the treatment of diseases involving cell proliferation
Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said...
US-8,143,246 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives
The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula I ##STR00001## wherein R.sub.1 is H,...
US-8,143,245 Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine for the preparation of a drug having a...
This invention relates to the use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine as well as its pharmaceutically acceptable salts for the...
US-8,143,244 Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
US-8,143,243 Compounds for the treatment of hepatitis C
The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C...
US-8,143,242 Malonamide derivatives with antithrombotic activity
The present invention relates to compounds of formula I, ##STR00001## The compounds of formula I are valuable pharmacologically active compounds. They exhibit...
US-8,143,241 DNA damage repair inhibitors for treatment of cancer
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR...
US-8,143,240 17.alpha., 21-dihydroxypregnene esters as antiandrogenic agents
17.alpha.,21-Dihydroxypregna-4,9-diene-3,20-dione and 17.alpha.,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters of having remarkable antiandrogenic...
US-8,143,239 Composition for inhalation
The invention relates to a formulation comprising formoterol and budesonide for use in the treatment of respiratory diseases. The composition further contains...
US-8,143,238 Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin D compound
Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an...
US-8,143,237 Anti-cancer drugs, and uses relating for malignant melanoma and other cancers
Selenopheno triazene analogs, their compositions, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, and pharmaceutically acceptable salts and...
US-8,143,236 Chemoprotective methods
Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of,...
US-8,143,235 Use of dietary fibres against muscle wasting
A composition nutritional containing dietary fibres is useful for the treatment of muscle wasting, if the dietary fibre comprise at least 30 wt. % of...
US-8,143,234 Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function...
US-8,143,233 RNA aptamers and methods for identifying the same
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and...
US-8,143,232 Gene fusion targeted therapy
The present invention relates to compositions and methods for cancer therapy, including but not limited to, targeted inhibition of cancer markers. In...
US-8,143,231 Method of reducing HIV-replication in human body tissue
Mononuclear phagocytes are reservoirs, vehicles of dissemination, and targets for persistent HIV infection. However, not all MP population equally support viral...
US-8,143,230 Compounds and methods for modulating expression of PCSK9
The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in...
US-8,143,229 Method for production of a transformed cell
A method for incorporating a biomolecule into a cell including the steps: i) production of a complex from a biomolecule and a polymer which may be obtained by...
US-8,143,228 Agents capable of downregulating an MSF-A dependent HIF-1.alpha. and use thereof in cancer treatment
Methods and pharmaceutical compositions for the treatment of cancer or acute ischemia are provided. Also provided are methods of identifying agents capable of...
US-8,143,227 Azithromycin for treatment of skin disorders
Azithromycin has increased efficacy in treating acne and other skin conditions when administered systemically at low doses, below those previously known to...
US-8,143,226 Tyrosine kinase receptor antagonists and methods of treatment for breast cancer
A method of treatment is disclosed whereby cancer cells are brought into contact with a formulation comprising an inhibitor of tyrosine kinase receptors. The...
US-8,143,225 Pharmaceutical compositions including low dosages of desmopressin
The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 .mu.g desmopressin and a pharmaceutically acceptable carrier. The...
US-8,143,224 Oxidant resistant apolipoprotein A-1 and mimetic peptides
A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation.
US-8,143,223 Cytoprotection by means of phosphotyrosine
The present invention relates to a method for protecting biological material from cell damaging factors, a method for producing a pharmaceutical composition for...
US-8,143,222 Modular platform for targeted therapeutic delivery
Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free...
US-8,143,221 Use of ADNF polypeptides for treating peripheral neurotoxicity
This invention relates to the use of ADNF polypeptides in the treatment of neurotoxicity induced by chemical agents or by disease processes. The ADNF...
US-8,143,220 Dosing regimens for neural stem cell proliferating agents and differentiating agents for the treatment of...
Effective dosing regimens for neural stem cell proliferating and differentiating agents, kits comprising effective dosing regimens for neural stem cell...
US-8,143,219 Methods for prevention and treatment of acute renal injury
The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood...
US-8,143,218 Treatment of skin, and wound repair, with thymosin beta 4
Compositions and methods for treatment of skin utilizing thymosin .beta.4.
US-8,143,217 Use of DPP-IV inhibitor to reduce hypoglycemic events
The invention relates to a method to reduce the hypoglycemic events, especially sever hypoglycemic events resulting from insulin treatment, wherein the patient...
US-8,143,216 Modified human growth hormone
Modified growth hormone polypeptide and uses thereof are provided.
US-8,143,215 Method of promoting weight loss
Compositions for enhancing satiety and weight loss in an individual, assays for assessing a tastant for enhancing satiety and weight loss, and methods of using...
US-8,143,214 Protein-polymer conjugates
Protein-polymer conjugates are described. Also described are a method for preparing a protein-polymer conjugate and its use in treating hepatitis B virus or...
US-8,143,213 Effect of TULA on HIV
A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a...
US-8,143,212 Dalbavancin compositions for treatment of bacterial infections
The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A.sub.0,...
US-8,143,211 Bioactive peptides
The present invention provides a cytotoxic 7 to 25-mer peptide with three or more cationic residues which has one or more non-generic bulky and lipophilic amino...
US-8,143,210 Enzyme treatment of foodstuffs for celiac sprue
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating...
US-8,143,209 Cleaning compositions with amphiphilic graft polymers based on polyalkylene oxides and vinyl esters
Laundry detergent and cleaning compositions comprising amphiphilic graft polymers based on water-soluble polyalkylene oxides (A) as a graft base and side chains...
US-8,143,208 Alkyl-capped alkoxylated esters and compositions comprising same
Process of making alkyl-capped alkoxylated esters. More specifically, a process of making alkyl-capped alkoxylated esters that are comprised substantially of...
US-8,143,207 Biocidal textile treatment agent
Textile treatment agent containing a biocidal compound, a perfume composition and a non-ionic surfactant, wherein the non-ionic surfactant has an HLB value of...
US-8,143,206 Cleaning composition having high self-adhesion and providing residual benefits
A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter; (b) at least one surfactant selected from the group...
US-8,143,205 Cleaning composition having high self-adhesion and providing residual benefits
A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter; (b) at least one surfactant selected from the group...
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