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Patent # Description
US-8,148,400 Thiazolyl compounds useful as kinase inhibitors
The invention provides compounds of formula II: ##STR00001## and pharmaceutically acceptable salts thereof. The formula II thiazolyl compounds inhibit...
US-8,148,399 Macrocyclic inhibitors of hepatitis C virus
Inhibitors of HCV replication of formula (I) ##STR00001## and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double...
US-8,148,398 Intermediate duration neuromuscular blocking agents and antagonists thereof
The invention provides novel neuromuscular blocking agents, methods of using the neuromuscular blocking agents as well as reagents, methods and kits for...
US-8,148,397 5-HT7 receptor antagonists
The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl...
US-8,148,396 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful...
US-8,148,395 Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
The present invention relates to azolopyridin-3-one derivatives of the general formula I with the meanings indicated in the description, their pharmaceutically...
US-8,148,394 Azaindoles having serotonin receptor affinity
Described herein are compounds with affinity for the 5-HT.sub.6 receptor, which have the general formula I: ##STR00001## wherein A, B, D, E, R.sub.1 to...
US-8,148,393 Zolpidem tablets
A zolpidem tablet having modified release is designed as a tablet-in-tablet dosage form.
US-8,148,392 2-indolyl imidazo [4,5-d] phenanthroline derivatives and their use in the treatment of cancer
2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula (I) and methods of using same in the treatment of cancer, in particular, solid cancers and leukemia...
US-8,148,391 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
US-8,148,390 Monocyclic anilide spirolactam CGRP receptor antagonists
The present invention is directed to compounds of Formula I: ##STR00001## (where variables A.sup.1, A.sup.2, B, J, K, m, n, R.sup.4, R.sup.5a, R.sup.5b and...
US-8,148,389 Pharmaceutical comprising PPAR agonist
An object of the present invention is to provide an agent for promoting proliferation of a meibomian gland epithelial cell and a corneal epithelial cell, as...
US-8,148,388 2,4 (4,6) pyrimidine derivatives
The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The...
US-8,148,387 AKT and P70 S6 kinase inhibitors
The present invention provides AKT and p70 S6 kinase inhibitors of the formula: ##STR00001## The present invention also provides pharmaceutical compositions...
US-8,148,386 Agent for the prevention and treatment of prostatic hyperplasia comprising pyrazolopyrimidinone compound
The present invention relates to an agent for preventing and treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with...
US-8,148,385 Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Y.sub.12 receptor antagonists
The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: ##STR00001## wherein X.sub.1, X.sub.2,...
US-8,148,384 Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics
Compounds of formula I ##STR00001## wherein A.sup.1, A.sup.2, and A.sup.3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are...
US-8,148,383 Fused ring compound and use thereof
Provided is a novel compound represented by the following formula ##STR00001## Wherein each symbol is as defined in the specification, or a salt thereof, which...
US-8,148,382 Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity...
US-8,148,381 Potentiator of radiation therapy
A radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects,...
US-8,148,380 Antibacterial amide and sulfonamide substituted heterocyclic urea compounds
The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds...
US-8,148,379 Therapeutic agent for senile dementia
A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the following formula [1]: ...
US-8,148,378 Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal
A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): ...
US-8,148,377 Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side...
US-8,148,376 3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors
The present invention discloses 3,4-dihydroquinoxalin-2(1H)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or...
US-8,148,375 (Cyclopropylphenyl)phenyloxamides, method for the production thereof, and use of same as a medicament
The invention relates to (cyclopropylphenyl) phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
US-8,148,374 Modulators of pharmacokinetic properties of therapeutics
The present application provides for a compound of Formula IV, ##STR00001## or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions...
US-8,148,373 Compounds
The present invention relates to spirocyclic amide derivatives of the formula I, ##STR00001## pharmaceutically acceptable salts thereof, a process for their...
US-8,148,372 Metabotropic glutamate receptor isoxazole ligands and their use as potentiators--286
Compounds in accord with Formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, pharmaceutically...
US-8,148,371 Adenine compound and use thereof
A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an...
US-8,148,370 Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
Compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as defined in the disclosure, or an acid addition salt thereof,...
US-8,148,369 Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
Novel fused pyrazine compounds are disclosed that have a formula represented by the following: ##STR00001## The compounds may be prepared as pharmaceutical...
US-8,148,368 7-nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one or derivatives thereof for treating or preventing antiviral...
Surprising antiviral activity of 7-Nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one (Compound 1) was reported in the treatment or prevention of viral...
US-8,148,367 Renin inhibitors
Disclosed are compounds, pharmaceutical compositions, kits, articles of manufacture, methods of using, and methods of preparing compounds having the formula: ...
US-8,148,366 Substituted pyrazolo[3,4-E][diazepin-6-5(H)ones and analogues thereof, their preparation and their use as...
The invention relates to nitrogenous heterocyclic compounds of formula (I): ##STR00001## in which: R.sub.1 represents hydrogen, --(CH.sub.2).sub.m--NH.sub.2,...
US-8,148,365 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The...
US-8,148,364 Substituted bicyclic pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: ##STR00001## Wherein Y, Z, R1, R2, R3, R4,...
US-8,148,363 Heterocyclic compounds as factor IXA inhibitors
The present invention relates to novel heterocyclic compounds of Formulae I-III; as disclosed herein or a pharmaceutically acceptable salt, solvate, ester,...
US-8,148,362 Compound having heterocyclic ring
The invention provides a novel oxazolidinone derivative represented by the formula (I): ##STR00001## wherein Ring A is optionally substituted or fused and...
US-8,148,361 Kinase inhibitors
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof. The Formula (I) compounds inhibit the tyrosine kinase...
US-8,148,360 Supramolecular metallic complexes exhibiting both DNA binding and photocleavage
Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light...
US-8,148,359 Chelating agents of metal ions, their methods of preparation and their applications
The present invention relates to compounds that can be used as metal-ion-chelating agents or as depolluting agents, corresponding to general formula (I) below: ...
US-8,148,358 Blue colour filters with enhanced contrast
The invention relates to a process for enhancing the contrast of color filters comprising .alpha. copper phthalocyanine or .epsilon. copper phthalocyanine,...
US-8,148,357 Method for the production of resin particles
Resin particles are produced by adding a liquid material having a boiling point of 100.degree. C. or higher to an aqueous dispersion of resin particles to yield...
US-8,148,356 Acetylcysteine composition and uses therefor
This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents,...
US-8,148,355 Phophylactic and therapeutic use of hydroxysteroids
3-Hydroxy-7-hydroxy steroids and 3-oxo-7-hydroxy steroids, especially the 7.beta.-isomers thereof, and pharmaceutically acceptable esters thereof are useful for...
US-8,148,354 Use of 20(S)-protopanaxadiol in manufacture of antidepressants
The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The...
US-8,148,353 Polymorphs of fluticasone furoate and process for preparation thereof
Provided are polymorphs of fluticasone furoate and processes for preparation thereof.
US-8,148,352 Antimicrobial therapy for bacterial infections
The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential...
US-8,148,351 Enteropathy ameliorating composition
The present invention relates to a composition for preventing, ameliorating or treating a bowel disease, comprising galactomannan and/or arabinogalactan; a...
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