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Patent # Description
US-8,158,810 ALDH-2 inhibitors in the treatment of addiction
Disclosed are novel isoflavone derivatives having the structure of Formula I ##STR00001## which are useful as ALDH-2 inhibitors for treating mammals for...
US-8,158,809 Podophyllotoxin derivatives
4-O esters of podophyllotoxin and 4'-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and...
US-8,158,808 Synthesis and preparations of duloxetine salts
The invention relates to an improved process for the preparation of duloxetine, duloxetine intermediates, and duloxetine hydrochloride.
US-8,158,807 Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds utilizing bisulfite intermediate
The present invention provides for a process for preparing 6,6-Dimethyl-3-aza-bicyclo[3.1.0]hexane-2-sulfonate, an intermediate useful in the efficient...
US-8,158,806 DAT1
A synthetic diaminoketothiazole, its process of preparation and its use as a microtubule inhibitor, a probe for tubulin-microtubule system and a cytotoxic...
US-8,158,805 Azapeptide derivatives
This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel...
US-8,158,804 Chelating agents
The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as...
US-8,158,803 Heterocyclic antiviral compounds
Compounds having the formula I wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c and R.sup.6 are as defined herein are Hepatitis C virus...
US-8,158,802 Arthropodicidal anthranilamides
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4a,...
US-8,158,801 Violet laser excitable dyes and their method of use
The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection...
US-8,158,800 4-{3-[4-(3-{4-[amino (butoxycarbonylimino) methyl] phenoxy} propyl)-1-piperidinyl] propoxy}-N'-(butoxycarbonyl)...
To provide novel crystals of 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperid- inyl]propoxy}-N'-(butoxycarbonyl)benzamidine. Means for...
US-8,158,799 Hydroxyquinoline derivatives
Compounds of the formula I in which X, Y, R.sup.1, R.sup.1', R.sup.2, R.sup.3 have the meanings indicated in Claim 1, are inhibitors of cell proliferation and...
US-8,158,798 Coupling process for preparing quinolone intermediates
Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxy- lic acids. Borate ester compounds suitable for use in such process.
US-8,158,797 Oxazolidinone-quinolone hybrid antibiotics
The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant...
US-8,158,796 Process for the preparation of Rho-kinase inhibitor compounds
The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV,...
US-8,158,795 Process for the purification of neuromuscular blocking agents
A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium...
US-8,158,794 Hydroxyalkyl substituted imidazoquinoline compounds and methods
Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position,...
US-8,158,793 Demethylation of 14-hydroxy substituted alkaloid derivatives
The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of ...
US-8,158,792 Spiropiperidines for use as tryptase inhibitors
The present invention is directed to a compound of Formula (I): ##STR00001## or a form thereof, wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, R.sub.1, R.sub.2...
US-8,158,791 Aza-substituted spiro derivatives
A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: ##STR00001## [wherein X, Y, Z and W each independently represent...
US-8,158,790 Cyclic amine compound
The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula...
US-8,158,789 Arginine derivatives with NP-I antagonistic activity
The present invention is a compound of formula (I) or formula (II) which are suitable as NP-1 antagonists. ##STR00001##
US-8,158,788 Method for the nitration of 4,6-dihydroxy-2-methylpyrimidine
Disclosed is a method for the nitration of 4,6-dihydroxy-2-methylpyrimidine for the synthesis of ...
US-8,158,787 Process for producing trichloropyrimidine compound
A process for producing a trichloropyrimidine compound represented by the formula (2): ##STR00001## wherein R represents a hydrogen atom etc., comprising...
US-8,158,786 Inhibitors of Bruton's tyrosine kinase
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the...
US-8,158,785 5,7-disubstituted[1.3]thiazolo [4,5-D] pyrimidin-2(3H)-amine derivatives and their use in therapy
There are disclosed novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are...
US-8,158,784 Quinuclidine derivative useful in the preparation of mequitazine
The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for...
US-8,158,783 MTP inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant...
US-8,158,782 Biomolecule labeling reactants based on azacycloalkanes and conjugates derived thereof
This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said...
US-8,158,781 Polymorphic forms .alpha., .beta. and .gamma. of rifaximin
Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin .alpha. and rifaximin .beta., and a poorly crystalline form named rifaximin...
US-8,158,780 Processes for the preparation of ciclesonide and its crystal modification
Improved processes for the synthesis of ciclesonide, chemically termed as [11.beta.,16.alpha.(R)]-16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-- ...
US-8,158,779 Antiviral nucleosides
4-Amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxymethyl-3-methyl-tetra- hydrofuran-2-yl)-1H-pyrimidin-2-one (22) and prodrugs thereof are hepatitis C (HCV)...
US-8,158,778 Method for the desalting of saccharide solution and an anion exchanger
The present invention provides the means for suppressing the production of decomposition reactant, isomerization reactant, colored material, and so on when a...
US-8,158,777 Cellulose esters and their production in halogenated ionic liquids
Ionic liquids and cellulose ester compositions and processes for producing ionic liquids and cellulose esters. Cellulose esters can be produced by esterifying...
US-8,158,776 P2Y.sub.6 receptor agonists for treating lung diseases
This invention is directed to a method of enhancing or facilitating the clearance or the lung mucus secretions in a subject. This invention is also directed to...
US-8,158,775 Method for detaching protecting group on nucleic acid
The present invention provides a method for removing a 2-cyanoethoxymethyl (CEM) group, which substitutes the 2'-hydroxyl group of each ribose of an...
US-8,158,774 Method for introducing a nucleic-acid protecting group
The present invention relates to a simple, economical method for introducing substituent (I) at the 2'-hydroxyl group of the ribose of a ribonucleic acid...
US-8,158,773 RNAi modulation of RSV and therapeutic uses thereof
The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral...
US-8,158,772 Oligonucleotide sequences that identify species of animal
Methods for identifying animal species involving amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a...
US-8,158,771 Host cell protein knock-out cells for production of therapeutic proteins
The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein...
US-8,158,770 Content dependent inhibitors of cytidine deaminases and uses thereof
This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof.
US-8,158,769 Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the...
US-8,158,768 Immunostimulatory sequence oligonucleotides and methods of using the same
The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.
US-8,158,767 Polypeptides and methods for making the same
An isolated protein having at least 90% homology with the dimeric protein having the following amino acid sequence ##STR00001## with the proviso that at the...
US-8,158,766 Genes with ES cell-specific expression
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1,...
US-8,158,765 Water-treatment particle and a method of manufacturing thereof
A method of manufacturing water-treatment particles comprises respectively preparing a particle-fabricating solution that comprises chitinous composition and a...
US-8,158,764 Morphine derivatives
The present invention relates to new morphine-6-glucuronide derivatives, to pharmaceutical compositions thereof and uses thereof.
US-8,158,763 Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these
An asparagine-linked .alpha.2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked .alpha.2,6-oligosaccharide having undeca- to...
US-8,158,762 Anti-factor B antibodies and their uses
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular...
US-8,158,761 Wnt proteins and detection and treatment of cancer
The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and...
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