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Patent # Description
US-9,309,306 Anti-MCSP antibodies
The invention provides anti-MCSP antibodies and methods of using the same.
US-9,309,305 Anti-ricin antibodies and uses thereof
The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof...
US-9,309,304 Glycation cross-link breakers to increase resistance to enzymatic degradation
The present invention relates to a method to treat a grafts, implant, scaffold, and constructs, including allografts, xenografts, autografts, and prosthetics...
US-9,309,303 Complexation of fatty acid-conjugated molecules with albumin
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent...
US-9,309,302 Water soluble membrane proteins and methods for the preparation and use thereof
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
US-9,309,301 Glucagon/GLP-1 receptor co-agonists
Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
US-9,309,300 Chromosomal insertion of GFP into bacteria for quality control
An isolated mutated green fluorescent protein (gfp) gene for chromosomal insertion into a bacterium, wherein the gene is capable of being expressed in bacteria...
US-9,309,299 Spider silk fusion protein structures for binding to an organic target
A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural...
US-9,309,298 Anti-bacterial polypeptides and pathogen specific synthetic antibodies
The present invention provides polypeptides, compositions thereof, and methods for use of the polypeptides in treating bacterial infection and for use as...
US-9,309,297 DNA sequence, and recombinant preparation of group 4 major allergens from cereals
The present invention relates to the provision of DNA sequences of group 4 major allergens from cereals. The invention also encompasses fragments, new...
US-9,309,296 Optically-based stimulation of target cells and modifications thereto
Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for...
US-9,309,295 Genetically modified filamentous fungi and uses thereof
The present invention relates to a filamentous fungus comprising a genetic modification in one more hydrophobin genes and the use of the same as host cell for...
US-9,309,294 Haemophilus influenzae type IV pili
The invention described herein relates to a Haemophilus influenzae (H. influenzae) regulon encoding type IV pili. In particular, the invention relates to type...
US-9,309,293 Surface exposed Haemophilus influenzae protein (protein; pE)
The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino...
US-9,309,292 Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery...
US-9,309,291 Broad spectrum influenza A neutralizing vaccines and D-peptidic compounds, and methods for making and using the...
GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using the...
US-9,309,290 Computationally optimized broadly reactive antigens for H1N1 influenza
The generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates is described. The...
US-9,309,289 Replication-defective arenavirus vectors
The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic...
US-9,309,288 Selective .alpha..sub.v.beta..sub.3 receptor peptide antagonist for therapeutic and diagnostic applications
The present invention is related to new peptide antagonists of .alpha..sub.v.beta..sub.3 receptor, designed on the basis of the crystal structure of integrin...
US-9,309,287 Inhibitors of TLR signaling by targeting TIR domain interfaces
TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR)...
US-9,309,286 Compositions and methods for augmenting permeability barriers
Compositions and methods for activating MK2, augmenting permeability barriers, such as epithelial and/or endothelial barriers, and treating diseases,...
US-9,309,285 Macrocyclic broad spectrum antibiotics
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds...
US-9,309,284 Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of...
Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and...
US-9,309,283 Prodrugs of peptide epoxy ketone protease inhibitors
Provided herein are compounds of formula (I): ##STR00001## which are pro-drugs of epoxy ketone protease inhibitors. The compounds disclosed herein include one...
US-9,309,282 Solid phase for mixed-mode chromatographic purification of proteins
Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore...
US-9,309,281 Method of downstream processing for conversion of human insulin precursor molecule into a functional human...
In one aspect, methods relate to the field of recombinant DNA therapeutics. Methods may involve bio-informatics design, synthesis of artificial genes for a...
US-9,309,280 Protein purification
The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange...
US-9,309,279 Macrocyclic hepatitis C serine protease inhibitors
The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said...
US-9,309,278 Method for modification of organic molecules
The present invention is directed to a method of alkylating a thiol group (R--S--H) or seleno group (R--Se--H) in a target molecule wherein the method...
US-9,309,276 Synthetic lipid A derivative
The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for...
US-9,309,275 3'-deoxy nucleosides for the treatment of HCV
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments,...
US-9,309,274 Redox-active structures and devices utilizing the same
A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive...
US-9,309,273 Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
US-9,309,272 Metal oxide particles aftertreated with organic phosphorus compounds
The invention relates to metal oxide particles and/or metal hydroxide particles, aftertreated with an organic phosphorus compound, process for the preparation...
US-9,309,271 Preparation of isocyanato silanes
A process for the preparation of alkoxysilyl group-containing isocyanate compounds which includes the step of reacting carbonyl chloride ClC(.dbd.O)Cl with an...
US-9,309,270 Process for the silylation of 2-amino-1,3,5-triazines
The present invention relates to a method for silylating 2-amino-1,3,5-triazines of the general formula (I) ##STR00001## in which R.sup.1 and R.sup.2 are...
US-9,309,269 Transition-metal-free silylation of aromatic compounds
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one...
US-9,309,268 Borate moiety-contained linker and bio-sensing element containing the same
A borate moiety-contained linker and a bio-sensing element containing the same are disclosed. The borate moiety-contained linker can be used to modify a sensing...
US-9,309,267 Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients,...
US-9,309,266 High-performing stable green replacements for ammonium perchlorate
A highly energetic, high-oxygen carrier suitable as high-performing green replacement for ammonium perchlorate includes halogen-free ionic salts consisting of...
US-9,309,265 Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically...
US-9,309,264 Method for adsorbing carbon dioxide onto porous metal-organic framework materials, method for cooling porous...
The present invention provides a method for adsorbing carbon dioxide onto porous metal-organic framework materials, a method for cooling porous metal-organic...
US-9,309,263 Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula...
US-9,309,262 Thienylindole azepines as serotonin 5-HT.sub.2C receptor ligands and uses thereof
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and...
US-9,309,261 Spirooxindole derivative and process for producing the same
Disclosed is a compound of formula I: wherein R.sup.1?, R.sup.2?, R.sup.3?, R.sup.4?, R.sup.5?, n and m are defined herein. The compound of formula I is...
US-9,309,260 Inhibitors of hepatitis C virus
A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition...
US-9,309,259 Process for ixabepilone, and intermediates thereof
The present invention relates to a novel process of making ixabepilone, ixabepilone derivatives and analogues, and intermediates thereof.
US-9,309,258 Process for N-dealkylation of tertiary amines
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which...
US-9,309,257 Preparation of oxycodone base form 14-hydroxycodeinone sulfate
Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone...
US-9,309,256 Pharmaceutically active dimers linked through phenolic hydroxyl groups
Pharmaceutically active homo-dimers of opioid and other pharmaceutically active agents characterized by a single phenolic hydroxyl group wherein the respective...
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