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Patent # Description
US-9,315,548 Peptoid oligomers, pharmaceutical compositions and methods of using the same
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: ##STR00001## The peptoids demonstrate antimicrobial activity...
US-9,315,547 Nuclear targeting sequences
Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides...
US-9,315,546 Growth hormone secretatogue receptor antagonists and uses thereof
The present invention provides novel peptides that can modulate the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and sub-types, isoforms and...
US-9,315,545 Hepcidin mimetic peptides and uses thereof
Compounds and methods are described herein that can be used to treat subjects for conditions related to hepcidin activity, such as but not limited diseases of...
US-9,315,544 Method of treating eosinophilia by administering an immunomodulating peptide
A method of treating or preventing inflammatory related diseases in a subject in need thereof comprising administering to said subject a pharmaceutically...
US-9,315,543 Tyrosine based linkers for the releasable connection of peptides
The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g....
US-9,315,542 Prodrugs of peptide epoxy ketone protease inhibitors
This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
US-9,315,541 Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
Disclosed is a method for the conversion of a compound of formula 3 to a compound ##STR00001## of formula 4, wherein R is an acetyl group or an...
US-9,315,540 Process for the preparation of fulvestrant
The present invention relates to an improved process for the preparation of Fulvestrant (I). Also, provided is novel intermediate of Fulvestrant and a process...
US-9,315,539 11 beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and...
The present invention relates to novel 11-.beta. estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of...
US-9,315,538 Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a...
US-9,315,537 Multiple orthogonal labelling of oligonucleotides
In summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably RNA or DNA, by simultaneously performing...
US-9,315,536 Self-assembling oligonucleotides and methods
A composition comprising individual single-stranded oligonucleotides capable of self assembling to form a pair of complementary, substantially contiguous single...
US-9,315,535 Nucleoside and nucleotide having nitrogen-containing heterocycle structure
The present invention provides compounds shown by the formula: ##STR00001## wherein Y.sup.1 is CR.sup.6 or N, Y.sup.2 is CR.sup.7 or N, Y.sup.3 is CR.sup.8 or...
US-9,315,534 Radiologic agents for monitoring alzheimer's disease progression and Evaluating a Response to Therapy and...
Disclosed are certain cycloSalingenyl pyrimidine nucleoside monophosphates comprising positron emitters or gamma-emitting radiohalides, uses thereof for...
US-9,315,533 Lactose crystallisation
The invention relates to a method of crystallizing lactose from a lactose-containing liquid comprising the steps of providing a lactose-containing liquid...
US-9,315,532 Fatty acid carbohydrate hybrid molecules as therapeutic agents and methods thereof
Described herein are fatty acid carbohydrate hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using...
US-9,315,531 Titanocene-gold derivatives comprising thiolato ligands
Titanocene-gold compounds are provided that are useful for treating cancers. The disclose compounds generally have a formula given by: ##STR00001##
US-9,315,530 Adsorption of immunopotentiators to insoluble metal salts
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention...
US-9,315,529 Methods of forming single source precursors, methods of forming polymeric single source precursors, and single...
Methods of forming single source precursors (SSPs) include forming intermediate products having the empirical formula ...
US-9,315,528 Method for the manufacture of phosphonoalkyl iminodiacetic acid
An improved method for the manufacture of phosphonoalkyl iminodiacetic acid M.sub.2PO.sub.3--X--N--(CH.sub.2COOM).sub.2 wherein X is a C.sub.1-6 linear or...
US-9,315,527 Synthesis and applications of peripherally asymmetric aryl POSS compounds
A method of synthesizing peripherally asymmetric aryl polyhedral oligomeric silsesquioxane (ArPOSS) compounds. The method comprises: ##STR00001## wherein Ph is...
US-9,315,526 Pyridyldiamido transition metal complexes, production and use thereof
Pyridyldiamido transition metal complexes are disclosed for use in alkene polymerization to produce high melting point polyolefins.
US-9,315,525 Synthetic route for the preparation of .alpha.-amino boronic acid derivatives via substituted alk-1-ynes
A process for producing bortezomib N-(pyrazin-2-yl)carbonyl-L-phenylalanine-L-leucine boronic acid) comprising the step of deprotecting the compound of formula...
US-9,315,524 Magnetic resonance imaging agents for calcification
The present invention discloses magnetic resonance compatible contrast agents for water-poor structures, such as bone and tissue calcification. In particular,...
US-9,315,523 Cyclic dinucleosides
Provided herein are compounds of formula Ia: ##STR00001## and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula...
US-9,315,522 Antibacterial compounds
The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of...
US-9,315,521 Pyrimidines as novel therapeutic agents
The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers,...
US-9,315,520 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,- 3-thiazol-4-yl amides
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have...
US-9,315,519 Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as...
US-9,315,518 Imidazopyridin-2-one derivatives
The present invention is directed to imidazopyridin-2-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR.sup.2...
US-9,315,517 Imidazol-piperidinyl derivatives as modulators of kinase activity
The invention provides novel imidazol-piperidinyl derivatives of formula (I) ##STR00001## in which R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3, X.sup.4 and n...
US-9,315,516 Benzodithiophene derivatives and their use as photoluminescent compounds
Compound comprising a benzoetherodiazole group of formula (I) and at least one benzodithiophene group or a mixture of compounds comprising a benzoetherodiazole...
US-9,315,515 Method of making internal dehydration products of sugar alcohols
A process is provided for making isohexides such as isosorbide with reduced color and/or improved color stability on storage, wherein ionic species in the crude...
US-9,315,514 1,3-dioxanomorphides and 1,3-dioxanocodides
The application is directed to compounds of Formula I ##STR00001## and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein G,...
US-9,315,513 Benzimidazole derivatives and their pharmaceutical compositions and uses
The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula...
US-9,315,512 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the...
US-9,315,511 Methods for preparing functional tetraazacycloalkane compounds using a specific cyclic bisaminal compound
Special C-functionalized cyclic bisaminal compounds having formula (I) or (II), their salts or solvates, methods for their preparation, their uses, and methods...
US-9,315,510 Method and application of unsymmetrically meso-substituted porphyrins and chlorins for PDT
Biologically active compounds are provided that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer,...
US-9,315,509 Diamine derivatives as inhibitors of leukotriene A4 hydrolase
This invention is directed to compounds of formula (I): ##STR00001## where r, q, R, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c, R.sup.6a,...
US-9,315,508 Treating diabetes with dipeptidyl peptidase-IV inhibitors
The present invention is directed to novel substituted dihydropyrrolopyrazoles of structural Formula I which are inhibitors of the dipeptidyl peptidase-N enzyme...
US-9,315,507 Compounds as HIF-1alphainhibitors and manufacturing process thereof
The present invention relates to novel compounds as HIF-1.alpha. inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds...
US-9,315,506 18F-labelled folates
The present invention is directed towards new .sup.18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety,...
US-9,315,505 Heterocyclic compounds and uses thereof
Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the isoquinolone entities, and methods of using these chemical...
US-9,315,504 Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3',4':4,5]pyrrolo ...
The present invention provides methods for the preparation of 4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido-[3',4':4,5]-pyrrolo[1,2,3- ...
US-9,315,503 Kinase inhibitors
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR00001## wherein R.sup.2, W, A, Y and R.sup.1 are as defined in the specification,...
US-9,315,502 Imidazopyridine derivatives
The present invention relates to compounds of general formula ##STR00001## wherein Ar is phenyl or pyridinyl; X.sup.1 is N or CH, X.sup.2 is N or CH, with the...
US-9,315,501 Bicyclic heterocycles as BET protein inhibitors
The present invention relates to bicyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment...
US-9,315,500 Bicyclic heteroaryl cycloalkyldiamine derivatives
The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as SYK inhibitors and to...
US-9,315,499 Cytomegalovirus inhibitor compounds
Compounds of Formula (I) wherein n, m, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R5 and R6 are defined herein, are useful for the treatment of cytomegalovirus disease...
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