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Patent # Description
US-9,321,759 Methods and use of bifunctional enzyme-building clamp-shaped molecules
This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for inhibiting cell proliferative disorders,...
US-9,321,758 Amorphous salt of a macrocyclic inhibitor of HCV
The amorphous form of the sodium salt of the macrocyclic inhibitor of HCV of formula: ##STR00001## as well as processes for manufacturing this salt.
US-9,321,757 Heterocyclic compound
The present invention provides a heterocyclic compound having an IRAK-4 inhibitory action, which is useful for the prophylaxis or treatment of inflammatory...
US-9,321,756 Azole compounds as PIM inhibitors
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of...
US-9,321,755 Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl- ...
US-9,321,754 Gelatinase inhibitors and prodrugs
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix...
US-9,321,753 Inhibitors of Flaviviridae viruses
Provided are compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided...
US-9,321,752 Pyrazole derivative
Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): ...
US-9,321,751 Piperine derivatives and uses thereof
The present invention provides novel piperine derivatives. The present pharmaceutical or food composition containing a piperine derivative as an active...
US-9,321,750 ROR modulators and their uses
The invention relates to ROR modulators; compositions comprising an effective amount of a ROR modulator; and methods for treating or preventing diseases...
US-9,321,749 Heterocyclic compounds and uses thereof
Disclosed herein are novel heterocyclic compounds, their salts, pharmaceutical compositions comprising such compounds and salts, and their uses in modulating...
US-9,321,748 Aminopyridine derived compounds as LRRK2 inhibitors
The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases...
US-9,321,747 Acid addition salt of substituted pyridine compound
The present invention provides a salt of a substituted pyridine compound which has excellent CETP inhibition activity and is useful as a medicament. The present...
US-9,321,746 Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
The present invention relates to compounds of formula I: in which n, m, X, Y.sub.1, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the Summary of...
US-9,321,745 Inhibition of neovascularization by inhibition of prostanoid IP receptors
There are provided inter alia methods and compounds useful for decreasing choroidal neovascularization in a subject in need thereof.
US-9,321,744 Method for preparing 2,5-furan dicarboxylic acid
Method for preparing 2,5-furan dicarboxylic acid is provided, which includes contacting a furan composition with an oxidant in the presence of a catalyst...
US-9,321,743 Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of...
US-9,321,742 N1-cyclic amine-N5-substituted biguanide derivatives, methods of preparing the same and pharmaceutical...
A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a...
US-9,321,741 Copper plating bath containing a tertiary amine compound and use thereof
Provided is a copper plating technique that enables the filling of high aspect-ratio via-holes and through-holes in semiconductor substrates such as silicon...
US-9,321,740 Tetrazole compounds and methods of making and using same
Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various...
US-9,321,739 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of...
US-9,321,738 N-alkyltriazole compounds as LPAR antagonists
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
US-9,321,737 CDK8-CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer
The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates...
US-9,321,736 Pyrimidine cyclohexyl glucocorticoid receptor modulators
The present invention provides a class of pyrimidinedione cyclohexyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
US-9,321,735 Insecticidal triazines and pyrimidines
The present invention describes novel triazines, their related pyrimidines and their use in controlling insects. This invention also includes new synthetic...
US-9,321,734 N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H- )-carboxamide derivatives
This present disclosure is related to the field of to N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2- H)-carboxamide compounds and...
US-9,321,733 Crystalline pharmaceutically active ingredients
The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active...
US-9,321,732 Phenyl(oxy/thio)alkanol derivatives
The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to processes for preparing these compounds, to compositions comprising these...
US-9,321,731 Substituted hydroxamic acids and uses thereof
This invention provides compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, G, m, n, p and q have values as described in the specification,...
US-9,321,730 Method of making and administering quinoline derivatives as anti-cancer agents
The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid...
US-9,321,729 Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
Certain substituted pyridyl amide compounds are histamine H.sub.3 receptor modulators useful in the treatment of histamine H.sub.3 receptor-mediated diseases.
US-9,321,728 Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising...
The present invention relates to a beta-alanine derivative, pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same as an...
US-9,321,727 Pyridine derivatives as agonists of the CB2 receptor
The invention relates to a compound of formula (I) ##STR00001## Wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined as in the description and in the...
US-9,321,726 Process for preparing roflumilast
The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic...
US-9,321,725 Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-- methylpyridin-2-yl)benzoic...
US-9,321,724 Heteroaryl compounds with A-cyclic bridging unit
This invention relates to certain heteroaryl compounds which may be used as medicaments, more specifically as medicaments for treating animals. The medicament...
US-9,321,723 Method of making a templating agent
A method for preparing 1-adamantyltrimethylammonium methylcarbonate or N,N-dimethyl-3,5-dimethylpiperidinium methylcarbonate is disclosed. The method comprises...
US-9,321,722 Bis-indolic derivatives, their uses in particular as antibacterials
The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
US-9,321,721 Kinase inhibitors
The present invention relates to compounds of formula I ##STR00001## or a pharmaceutically acceptable salts thereof; wherein the variables R.sup.1--R.sup.5,...
US-9,321,720 Process for preparing isocyanates
Process for preparing isocyanates by reacting the corresponding amines with phos-gene comprising (a) providing at least one amine-comprising feed stream and at...
US-9,321,719 Crystalline polymorphic forms of monosodium N-[-8-(2-hydroxybenzoyl)amino]caprylate
The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate ("SNAC"), including two hydrates, a methanol...
US-9,321,718 Benzamide derivatives and their use as HSP90 inhibtors
The invention provides a compound which is (a) a phenylamide derivative of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt,...
US-9,321,717 Process for rapid identification and preparation of crystalline forms
Disclosed is a method of rapid identification and preparation of a crystalline form of an organic compound by using sub-gram level of said organic compound,...
US-9,321,716 Compositions and methods for the treatment of metabolic syndrome
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and...
US-9,321,715 Simulated moving bed chromatographic separation process
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which...
US-9,321,714 Processes and catalysts for conversion of 2,5-dimethylfuran derivatives to terephthalate
A process of making terephthalic acid or a derivative of terephthalic acid is described. The process includes reacting a derivative of 2,5-dimethylfuran, with a...
US-9,321,713 Hyperforin analogs, methods of synthesis, and uses thereof
The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin...
US-9,321,712 Process for the preparation of ospemifene
The present invention is related to the process for the preparation ospemifene or (Z)-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol (I) and to...
US-9,321,711 System and process for making phenol and/or cyclohexanone
A system for producing high-purity phenol and/or cyclohexanone from cyclohexylbenzene oxidation includes a cyclohexylbenzene feed hydrogenation reactor, a...
US-9,321,710 Process for producing phenol
In a process for producing phenol, a composition comprising an alkylaromatic compound is contacted with an oxygen-containing stream in the presence of an...
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