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Patent # Description
US-9,328,148 Campylobacter immunogenic compositions and uses thereof
The present invention provides immunogenic compositions against Campylobacter and methods for using the immunogenic composition to generate an immune response...
US-9,328,147 Recombinant baculovirus vector and uses thereof
Disclosed herein is a recombinant viral construct and its uses thereof. The recombinant viral construct is capable of simultaneously expressing three exogenous...
US-9,328,146 Lentiviral gene transfer vectors and their medicinal applications
The present invention relates to the design of gene transfer vectors and especially provides lentiviral gene transfer vectors suitable for either a unique...
US-9,328,145 Designing a soluble full-length HIV-1 gp41 trimer
Described herein is a soluble HIV-1 retrovirus transmembrane glycoprotein gp41 trimer (Soc-gp41M-Fd) containing a partial ectodomain and the cytoplasmic domain,...
US-9,328,144 HSV-1 epitopes and methods for using same
The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of...
US-9,328,143 Peptide derivatives and use thereof as carriers for molecules in the form of conjugates
The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to...
US-9,328,142 Lipopeptide inhibitors of RAS oncoproteins
The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal .alpha.-helix or hypervariable...
US-9,328,141 Polypeptides for the treatment or prevention of cancer and uses thereof
Disclosed herein are polypeptides or their derivatives and their application. The polypeptides and their derivatives can treat or prevent cancer. The...
US-9,328,140 Modified mini-hepcidin peptides and methods of using thereof
Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.
US-9,328,139 Cyclin based inhibitors of CDK2 and CDK4
Structural and functional analysis of peptide inhibitor binding to the cyclin D1 groove has been investigated and used to design peptides that provide the basis...
US-9,328,138 HCV NS3 protease inhibitors
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their...
US-9,328,137 Hydrogel-forming material
There is provided a hydrogel-forming material from which a hydrogel can be formed with a simpler method and under milder conditions. A hydrogel-forming material...
US-9,328,136 Method of protein purification
A method for producing a target protein is provided, which includes steps described below. A crude extract including a fusion protein is provided. The fusion...
US-9,328,135 Method for producing porous silk fibroin material
A method for producing a porous silk fibroin material, containing steps of: freezing a silk fibroin solution containing a silk fibroin aqueous solution having...
US-9,328,134 Carbohydrate phosphonate derivatives as modulators of glycosylation
Compounds of Formula (I) are useful as modulators of glycosylation. Compounds of Formula (I) have the following structure: (I) and the definitions of the other...
US-9,328,133 Ferric organic compounds, uses thereof and methods of making same
The present invention discloses a novel form of ferric organic compounds, including a form of ferric citrate, which are soluble over a wider range of pH, and...
US-9,328,132 Ruthenium complexes, their use in the metathesis reactions, and a process for carrying out the metathesis reaction
The invention is related to the metal complexes of the general formula (1). The invention is related also to the use of metal complexes of the formula 1 as...
US-9,328,131 Benzimidazolium compounds
The present invention relates to compounds of general formula (I) ##STR00001## and the tautomers and the salts thereof, particularly the pharmaceutically...
US-9,328,130 Method of treating organism by biologically active compounds specifically delivered into mitochondria,...
This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of...
US-9,328,129 Peptidomimetic inhibitors of PSMA
Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or...
US-9,328,128 Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport
The present invention is directed to fluorophosphates, and pharmaceutical compositions thereof, which are inhibitors of intestinal apical sodium/phosphate...
US-9,328,127 System for controlling the reactivity of boronic acids
A protected organoboronic acid includes a boron having an sp.sup.3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic...
US-9,328,126 Norbornenylhydrocarbylene dihydrocarbylboranes and methods of making the same
Embodiments of norbornenylhydrocarbylene dihydrocarbylboranes represented by the Formula (I), ##STR00001## and methods of forming such ...
US-9,328,125 Bivalent AMPA receptor positive allosteric modulators
Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.
US-9,328,124 BACE inhibitors
The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease: wherein A is selected from the...
US-9,328,123 Rotenone derivatives and a use thereof
The present invention relates to rotenone derivatives and a use of the same. Particularly, the present inventors identified rotenoisin A and B which are...
US-9,328,122 7-substituted Hanfangichin B derivative, and preparation method and use thereof
The present invention belongs to the field of natural medicine and pharmaceutical chemistry and specifically relates to novel 7-substituted fangchinoline...
US-9,328,121 Fused heterocyclic compound
The fused heterocyclic compound represented by formula (1) has excellent effectiveness in pest control. ##STR00001## In the formula (1), J represents formula...
US-9,328,120 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I). ##STR00001## wherein R.sup.1 is a 5 or 6 membered aromatic...
US-9,328,119 AZA-pyridone compounds and uses thereof
Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same....
US-9,328,118 Nitrogen-containing bicyclic aromatic heterocyclic compound
[Problem] On the basis of a cathepsin S inhibitory effect, an excellent agent for treating or preventing autoimmune disease, allergic disease, graft rejection...
US-9,328,117 Bromodomain inhibitors and uses thereof
The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable...
US-9,328,116 Diazole lactams
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam...
US-9,328,115 Process for preparing meropenem trihydrate
Provided is a process for the preparation of meropenem trihydrate in high purity and high yield, including using a dry methanol solvate of meropenem, which can...
US-9,328,114 Hsp90 inhibitors
The present application provides compounds useful in the inhibition of Hsp90, and hence in the treatment of disease.
US-9,328,113 Substituted xanthine derivatives
This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention...
US-9,328,112 Tetracyclic CDK9 kinase inhibitors
Disclosed are compounds of Formula (Ia), and pharmaceutically acceptable salts thereof, ##STR00001## wherein X, Y, R.sup.1, R.sup.2, R.sup.3A, R.sup.3B, and...
US-9,328,111 Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors
The present invention provides a compound of Formula (I): ##STR00001## wherein the variables Z, n, Y and p are as defined herein, and pharmaceutically...
US-9,328,110 Substituted imidazo ring systems and methods
Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and...
US-9,328,109 Process for the preparation of benzohetero [1, 3] diazole compounds disubstituted with heteroaryl groups
Process for the preparation of a benzohetero-[1,3]diazole compound disubstituted with brominated heteroaryl groups which comprises reacting at least one...
US-9,328,108 Process for preparing an intermediate of the macrocyclic protease inhibitor TMC 435
The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,12aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetr- ...
US-9,328,107 Primary amines and derivatives thereof as modulators of the 5-HT.sub.2A serotonin receptor useful for the...
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A...
US-9,328,106 Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically...
US-9,328,105 Compounds and methods for regulating integrins
A method of treating inflammation, by administering an effective amount of a .beta.2 integrin agonist to a patient, and reducing inflammation. A method of...
US-9,328,104 Selective androgen receptor modulators
The present invention relates to a compound of Formula 1, 2 or 3: ##STR00001## wherein A is N or --CR.sub.0--, where R.sub.0 is hydrogen, C.sub.1-C.sub.6...
US-9,328,103 Compounds as tyrosine kinase modulators
The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are...
US-9,328,102 Slow release of organoboronic acids in cross-coupling reactions
A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a...
US-9,328,101 Crystalline form B of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydr- ...
The present invention relates to a novel crystalline form B of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydr- ...
US-9,328,100 Process for the preparation of .beta.-C-arylglucosides
The present application discloses a stereoselective process for the preparation of .beta.-C-arylglucosides that does not require the use of conventional...
US-9,328,099 Cyanomethylpyrazole carboxamides as janus kinase inhibitors
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
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