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Patent # Description
US-9,334,303 Peptide compound useful for inhibiting amyloid plaque formation
A peptide compound and composition useful for binding to amyloid-.beta. peptides and/or preventing or reducing the formation of amyloid plaques, especially by...
US-9,334,302 Method for removing FMOC group
The present invention relates to a method of removing an Fmoc group, including a step of mixing a compound represented by the formula (I): HS-L-COOH (I)...
US-9,334,301 Nucleic acid construct and method of preparing nanoparticle using the same
A nucleic acid construct, a method of preparing a nanoparticle by using the nucleic acid construct, and a nanoparticle and nanoparticle complex prepared using...
US-9,334,300 Vitamin B6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
Compounds and compositions are provided, as are methods of using them to treat infections, neoplastic disease, including pancreatic cancer, inflammatory...
US-9,334,299 Water-soluble camptothecin derivative, pharmaceutical composition and use thereof
The present invention relates to a water soluble derivative of camptothecin and preparation method thereof, the derivative having a structure of formula I and...
US-9,334,298 Microsphere comprising a lanthanide metal complex
The invention is directed to a method for preparing a microsphere comprising a lanthanide metal phosphate complex, a microsphere, a powder comprising a number...
US-9,334,297 Chiral imidazolium salts for asymmetric catalysis
Planar chiral N-heterocyclic carbenes that incorporate an iron sandwich complex into the NHC framework are disclosed for use in organocatalytic and transition...
US-9,334,296 Crystallization method and bioavailability
Preparation, in-vitro and in vivo characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid, suitable for pharmaceutical...
US-9,334,295 Fused aromatic PTP-1B inhibitors
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also...
US-9,334,294 Siloxane compound and process for producing the same
A siloxane compound comprises a plurality of siloxane repeating units and at least a portion of the siloxane repeating units are cyclosiloxane repeating units...
US-9,334,293 Method for producing alkyl chlorosilanes by way of rearrangement reactions
Alkyl chlorosilanes from the manufacture of dialkyldichlorosilanes are rearranged in continuous fashion to dialkyldichlorosilane by a rearrangement reaction in...
US-9,334,292 Alkaline earth metal-complexed metal bisamides
The present invention relates to alkaline earth metal-complexed metal bisamides of the formula (I), to a process for preparation thereof and to the use thereof...
US-9,334,291 Antiviral compounds highly effective as HCV-NS5A inhibitor
Provided are compounds antiviral compounds represented by formula Ia and Ib: ##STR00001## that are highly potent as HCV NS5A inhibitors, where the structural...
US-9,334,290 Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
US-9,334,289 Cephem compound having catechol or pseudo-catechol structure
The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against...
US-9,334,288 Selective .beta.-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents
Compounds, compositions and methods are provided that comprise selective .beta.-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially...
US-9,334,287 High-fluidity non-caking dianhydrohexitol pellets
Dianhydrohexitol pellets, whose fluidity is preserved even after lengthy storage, include between 90% and 100%, preferably between 95% and 100%, and more...
US-9,334,286 Pharmacologically active compounds
The present invention relates to compounds of formula II ##STR00001## wherein X, Y, R.sub.2, R.sub.3, R.sub.4 and Ar are all as defined herein. The compounds...
US-9,334,285 Aldosterone synthase inhibitors
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein Cy, R.sup.1 and R.sup.2 are as...
US-9,334,284 Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
Inhibitors of p67.sup.phox protein are provided herein, as well as pharmaceutical compositions and methods recited thereto.
US-9,334,283 CCR1 antagonists and methods of use thereof
The invention provides compounds having the formula: ##STR00001## wherein R.sup.1 is halogen. The invention also provides compositions comprising the...
US-9,334,282 Macrocyclic indoles as hepatitis C virus inhibitors
The present invention relates to inhibitors of HCV replication of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary...
US-9,334,281 Fluorochromes for organelle tracing and multi-color imaging
Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei...
US-9,334,280 Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and method of producing...
A compound having the Formula as follows: ##STR00001## wherein R, R.sub.1 and R.sub.2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated...
US-9,334,279 Hepatitis C virus inhibitors
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit...
US-9,334,278 Pyrrolo[2,3-B]pyrazines as SYK inhibitors
The present invention relates to the use of novel pyrrolo[2,3-b]]pyrazines wherein all variable substituents are defined as described herein, which are SYK...
US-9,334,276 Forms and salts of a dihydropyrrolo[1,2c]imidazolyl aldosterone synthase or aromatase inhibitor
The invention relates to a phosphate salt or a nitrate salt of 4-(R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl-3-fluoro-benzonitrile, especially in crystalline...
US-9,334,275 Processes for preparing indoles
Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a...
US-9,334,274 N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and ...
The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: ##STR00001## which are JAK inhibitors, such as selective JAK1...
US-9,334,273 Efficient and stereoselective synthesis of 2'-fluoro-6'-methylene-carbocyclic adenosine (FMCA)
The invention provides a new convergent approach for the synthesis of 2'-fluoro-6'-methylene-carbocyclic adenosine (FMCA) from a readily available starting...
US-9,334,272 Derivatives of purinic and pyrimidinic antiviral agents and use thereof as potent anticancer agents
Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing...
US-9,334,271 Purine derivatives and their use in the treatment of disease
The invention relates to PI3K inhibitors of the formula (I).cndot. in which all of the variables are as defined in the specification, to their preparation, to...
US-9,334,270 Polymerizable (photosensitive or reactive) cyano-containing compound, a dye, and colored photosensitive composition
A compound represented by the following general formula (1). In the formula, A represents a benzene ring, a naphthalene ring and the like, wherein these rings...
US-9,334,269 Carboxamides as inhibitors of voltage-gated sodium channels
The present invention provides compounds that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav 1.7, and are therefore useful for the...
US-9,334,268 4-amino-imidazoquinoline compounds
This invention relates to novel 4-amino-imidazoquinoline compounds of the formula ##STR00001## wherein R.sup.1 to R.sup.4 are as defined in the description...
US-9,334,267 RAF inhibitor compounds
This invention provides compounds of Formula I: (Formula I should be inserted here) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions...
US-9,334,266 Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions...
Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the...
US-9,334,265 3-amino-pyrazole derivatives useful against tuberculosis
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: ##STR00001## Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and...
US-9,334,264 NAMPT inhibitors
Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is...
US-9,334,263 Compositions useful for treating disorders related to kit
Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
US-9,334,262 Methods of treating soft tissue defects
The specification discloses compositions and methods for treating a soft tissue defect of an individual.
US-9,334,261 Autotaxin inhibitor compounds
Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
US-9,334,260 Materials for electronic devices
The present adventure relates to novel compounds of the formula (I) or (II), to the use of the compounds in electronic devices, to a process for the preparation...
US-9,334,259 Aryloxyacetamide compound and pesticide
The present invention provides a pesticide comprising an aryloxyacetamide compound represented by formula (IV) (wherein in formula (IV), R.sup.1a represents an...
US-9,334,257 Methods of purifying and identifying the presence of and levels of procyanidin oligomeric compounds
The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to...
US-9,334,256 Agents and methods for treating ischemic and other diseases
This invention relates to compounds that modulate TRPM7 protein activity and use of the same for treatment or prophylaxis of ischemia, cancer, pain or glaucoma.
US-9,334,255 Method of producing beraprost
An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d...
US-9,334,254 Process for preparing sulfonamidobenzofuran derivatives
The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl...
US-9,334,253 Direct trifluoromethylations using trifluoromethane
A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for...
US-9,334,252 Process for preparing a divinylarene dioxide
A process for preparing a divinylarene dioxide including reacting (a) at least one divinylarene, (b) hydrogen peroxide, (c) at least one iron-containing...
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