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Patent # Description
US-9,340,610 Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions...
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use...
US-9,340,609 Antibodies against human angiopoietin 2
The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an...
US-9,340,608 Antibodies to endoplasmin and their use
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant...
US-9,340,607 Anitbodies specific for the protofibril form of beta-amyloid protein
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human .beta.-amyloid...
US-9,340,606 Immunization with amyloid-beta oligomers
The present invention provides methods of immunization against Alzheimer's Disease and compositions for use in such methods.
US-9,340,605 VHH for application in tissue repair, organ regeneration, organ replacement and tissue engineering
The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.
US-9,340,604 Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV)
This invention is directed to an antibody construct or fragment thereof derived from an RSV-infected human, such that the antibody construct binds with...
US-9,340,603 Neutralizing anti-influenza A virus antibodies and uses thereof
The invention relates to antibodies, and antigen binding fragments thereof, that bind to hemagglutinin and neutralize a group 1 subtype and a group 2 subtype of...
US-9,340,602 Matricryptic ECM peptides for tissue reconstruction
Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for...
US-9,340,601 Splice variants of the EGF receptor
The present invention relates to a novel form of human EGFR found in certain tumors and conditions. The protein is termed here mLEEK, and the cDNA that encodes...
US-9,340,600 Glucagon analogs exhibiting GIP receptor activity
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity....
US-9,340,599 Single chain CD40L fusion polypeptides
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules...
US-9,340,598 Tissue protective peptides and uses thereof
The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor...
US-9,340,597 Neuregulin variants and methods of screening and using thereof
The present invention provides polypeptide variants of neuregulin-1.beta. (NRG-1.beta.) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4....
US-9,340,596 Fusion protein comprising tumor necrosis factor related apoptosis inducing ligand and integrin ligand and use...
Provided is a fusion protein comprising a tumor necrosis factor related apoptosis inducing ligand (TRAIL), integrin ligands of .alpha.V.beta.3 and...
US-9,340,595 Crosslinking within coordination complexes
Crosslinked proteins, proteins and polymers, and polymers and methods of making the same are disclosed. In one illustrative embodiment, a method is provided...
US-9,340,594 VEGF antagonist formulations for intravitreal administration
Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration...
US-9,340,593 Method of treating diabetes by a CTRP12 polypeptide
The present invention provides substantially purified peptide portions of adipokine polypeptides, including, for example, C1q/TNF-related protein-12 (CTRP12), a...
US-9,340,592 CHO/CERT cell lines
The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a CERT...
US-9,340,591 Method of modulating the activity of a nucleic acid molecule
The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that...
US-9,340,590 Potent and selective inhibitors of Na.sub.V1.3 and Na.sub.V1.7
Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Nav1.7 inhibitor. In some disclosed embodiments, the...
US-9,340,589 Light-activated chimeric opsins and methods of using the same
Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively...
US-9,340,588 Peptide secreted by Lactobacillus plantarum with immunomodulating function
Among the fewer than 10 proteins primarily secreted by the species Lactobacillus plantarum, there is one of 30 kDa that contains an internal fragment without...
US-9,340,587 Albumin-free botulinum toxin formulations
This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to...
US-9,340,586 Streptococcus pyogenes antigens and corresponding DNA fragments
The present invention relates to antigens more particularly antigens of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen...
US-9,340,585 Competence stimulating peptide
The present invention concerns a new competence stimulating peptide identified in Firmicutes, in particular Streptococcus, and more preferably S. thermophilus...
US-9,340,584 Engineered thioredoxin-like fold proteins
The invention features compositions based on thioredoxin-like fold protein domains described as engineered thioredoxin-like fold proteins (ETRXs). These...
US-9,340,583 VIP fragments and methods of use
The invention relates to composition comprising a pharmaceutically effective amount of one or more functional vasoactive intestinal peptide (VIP) fragments, and...
US-9,340,582 Bioconjugates of synthetic apelin polypeptides
The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I' (SEQ ID NO: 1): ##STR00001## or an amide, an ester or a salt thereof,...
US-9,340,581 Ligands to radiation-induced molecules
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the...
US-9,340,580 Peptide with multiple epitopes
The present invention relates to peptides comprising multiple MHC Class II-binding T cell epitopes for tolerization therapy.
US-9,340,579 DPP-4 inhibitor
A DPP-4 inhibitor comprising a peptide represented by the formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (SEQ ID NO: 16) (wherein Xe is an amino acid residue with an...
US-9,340,578 Inhibitors targeting human ghrelin O-acyltransferase
Grhelin O-acyltransferase inhibitors using a triazole linkage to incorporate aromatic and alkyl substituents to mimic the natural octanoyl group attached to...
US-9,340,577 HLA binding motifs and peptides and their uses
The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding...
US-9,340,576 Methods of treating depression and other related diseases
The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
US-9,340,575 Agonists and antagonists of the urotensinergic system
Novel urotensin II receptor (UT) agonists and antagonists are described herein. More specifically, novel derivatives of urotensin II-related peptide (URP) are...
US-9,340,574 Inhibitors of protein tyrosine phosphatases
Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds...
US-9,340,573 Azaindolines
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as described in...
US-9,340,572 Taccalonolide microtubule stabilizers
The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.
US-9,340,571 Process for the purification of abiraterone acetate
The invention relates to a process for the purification of crude abiraterone acetate by treatment with polymer resins in aqueous solvent. The purified product...
US-9,340,570 Certain chemical entities, compositions, and methods
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,340,569 Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth
Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C....
US-9,340,568 Solid forms of an antiviral compound
Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluo- ...
US-9,340,567 Chemistry used in biosensors
The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes.
US-9,340,566 Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1)...
US-9,340,565 Crystalline forms
Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in...
US-9,340,564 Phenicol antibacterials
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these...
US-9,340,563 Salts of isophosphoramide mustard and analogs thereof
Disclosed herein are crystalline compounds of formula (I) ##STR00001## wherein A.sup.+ represents a hydroxylated aliphatic ammonium species; and X and Y...
US-9,340,562 Chromatographic material and method for preparation thereof
A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: ##STR00001## wherein...
US-9,340,561 Organic silicon compound and silane coupling agent containing the same
There is provided a novel organic silicon compound that can be used for a silane coupling agent. An organic silicon compound of Formula (1): ##STR00001## ...
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