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Patent # Description
US-9,359,653 High toughness secondary hardening steel
A secondary hardening steel alloy substantially lacking Cobalt is disclosed. In spite of the substantial lack of Cobalt, a steel alloy of the present disclosure...
US-9,359,652 Thermal treatment method for micromechanical horological parts
Thermal treatment method for a micromechanical horological component derived from the LIGA method and exhibiting very low thermal inertia, said method including...
US-9,359,651 Production of fermentable sugars and lignin from biomass using supercritical fluids
Methods are disclosed for the continuous treatment of biomass comprising a pretreatment step, wherein said biomass is contacted with a first supercritical,...
US-9,359,650 Biomass pre-treatment for co-production of high-concentration C5- and C6-carbohydrates and their derivatives
Described is a method of processing biomass to separate it into a liquid fraction enriched in solubilized C5-sugar-containing oligomers and C-5 sugar monomers...
US-9,359,649 Methods for collection, storage and transportation of biological specimens
The present invention provides methods for collecting, storing or transporting liquid suspension of biological specimens containing analytes of interest in a...
US-9,359,648 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein
A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are...
US-9,359,647 Probe for detection of polymorphism in EGFR gene, amplification primer, and use thereof
A polymorphism-detecting probe, an amplification primer and the use thereof are provided to enable simple and highly reliable determination of different...
US-9,359,646 Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the...
US-9,359,645 Methods for detecting diabetic nephropathy comprising measuring the expression of Smad1
A method of detecting proliferative diseases causing sclerosis, comprising measuring the expression of at least one substance selected from the group consisting...
US-9,359,644 Methods of identifying genetic mutations associated with charcot-marie-tooth neuropathy type 1C
In one aspect, the invention provides methods of identifying genetic mutations that are associated with peripheral neurological disease. The methods comprise...
US-9,359,643 Discrimination of blood type variants
The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r's,...
US-9,359,642 Method for preparing nucleic acid library, its uses and kits
Provided are a method of constructing a nucleic acid library, a method of determining a nucleic acid sequence of a nucleic acid sample, and a kit thereof. The...
US-9,359,641 Method and system for accurate alignment and registration of array for DNA sequencing
In a genome sequencing system and methodology, a protocol is provided to achieve precise alignment and accurate registration of an image of a planar array of...
US-9,359,640 Methods for synthesizing pools of probes
Compositions, methods and kits are disclosed for synthesizing and amplifying pools of probes using precursor oligonucleotides. In some aspects the precursor is...
US-9,359,639 Method for the detection of multiple single nucleotide variations or single nucleotide polymorphisms in a...
The present invention discloses a method for detecting multiple single nucleotide variations or polymorphisms in a single reaction tube, and the ...
US-9,359,638 Multi-nucleic-acid amplification reaction tool
According to one embodiment, a multi-nucleic-acid amplification reaction tool includes a support and a plurality of types of primer sets. The support is...
US-9,359,637 Methods and compositions for amplifying a detectable signal
Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of...
US-9,359,636 Methods for fixing and detecting RNA
The invention provides a method for fixing an RNA molecule in a biological sample. The method comprises contacting the biological sample with an...
US-9,359,635 Permuted and nonpermuted luciferase biosensors
A modified luciferase protein which is a sensor for molecules including cAMP, cGMP, calcium, chelators thereof, kinases, or phosphatases is provided. Also...
US-9,359,634 Fast reaction kinetics of enzymes having low activity in dry chemistry layers
The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for...
US-9,359,633 Biochemical markers for CVD risk assessment
A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as...
US-9,359,632 Devices, systems and methods for sample preparation
Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse,...
US-9,359,631 Method for observing a sample
A method for observing a sample is provided. The method includes the steps of: a) providing a volume (G, V) of a substantially transparent medium having a first...
US-9,359,630 Promoters for expressing genes in a fungal cell
The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides...
US-9,359,629 Cell culture processes
Culturing heterologous protein-secreting mammalian cells, such as CHO or BHK cells, at 35.1-36.5.degree. C. and/or at pH 7.15-7.20 and/or at a dissolved...
US-9,359,628 Protein glycosylation modification in methylotrophic yeast
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically...
US-9,359,627 Antibody production method
Provided is an antibody production method whereby it is possible to repeatedly acquire antibodies produced by fish without killing the fish. Specifically...
US-9,359,626 Glucosyltransferase enzymes
A process for producing poly alpha-1,3-glucan with reduced molecular weight is disclosed. The process comprises contacting water, sucrose, a polar organic...
US-9,359,625 Chemical engineering processes and apparatus for the synthesis of compounds
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive...
US-9,359,624 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the...
US-9,359,623 Methods and compositions for the production of fatty acids in photosynthetic prokaryotic microorganisms
Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green...
US-9,359,622 Method for biotechnological production of dihydrochalcones
A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or...
US-9,359,621 Processes of producing fermentation products
The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or...
US-9,359,620 Processing biomass
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels,...
US-9,359,619 Biomass liquefaction processes, and uses of same
Described are processes for the liquefaction of lignocellulosic biomass under the digestive action of dicarboxylic acid(s). Such digests can exhibit enhanced...
US-9,359,618 Simian subfamily E adenoviruses SAdV-39, -25.2, -26, -30, -37, and -38 and uses thereof
A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory...
US-9,359,617 Mammalian expression vector
The present invention describes new mammalian expression vectors comprising a novel combination of regulatory elements and one or more selection marker gene(s)....
US-9,359,616 Ribosomal polynucleotides and related expression systems
Provided herein is a synthetic or isolated polynucleotide encoding a mammalian 18S rRNA that is resistant to pactamycin. The pactamycin-resistance is conferred...
US-9,359,615 Preformed defense in plants
The present invention relates to plants having increased pre-formed defense, their production and uses. The invention more particularly discloses plants which...
US-9,359,614 Class of glyphosate resistance genes
The present disclosure relates to a novel class of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzymes, which enzymes are identifiable both by conserved...
US-9,359,613 Fermentative glycerol-free ethanol production
The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent...
US-9,359,612 Production of itaconic acid
The invention relates to a nucleic acid sequence encoding an itaconate transporting Major Facilitator Superfamily Transporter (MFST) gene sequence and the...
US-9,359,611 Recombinant microorganism and methods of production thereof
The invention relates, inter alia, to novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel...
US-9,359,610 Method for purifying GLA-domain coagulation proteins
A method for purifying GLA-domain coagulation proteins, includes the following steps: a) bringing a sample containing one or more GLA-domain coagulation...
US-9,359,609 Methods for treatment of alport syndrome
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified...
US-9,359,608 Modulation of signal transducer and activator of transcription 3 (STAT3) expression
Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to...
US-9,359,607 Methods of diagnosing and treating motor neuron diseases
Use of an agent which upregulates an activity or amount of miRNA-9 or miRNA-9* is disclosed for the preparation of a medicament for the treatment of a motor...
US-9,359,606 Anti-clusterin monotherapy for cancer treatment
The present invention provides a method of treating cancer in a subject afflicted with cancer comprising administering to the subject an anti-clusterin...
US-9,359,605 Method of treating cancer by inhibition of DNA repair proteins
Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The...
US-9,359,604 Inhibitor of IRS-1 for treating skin disorders
The present invention relates to an inhibitor of the expression of IRS-1 for treating an angiogenic and/or inflammatory skin disease. The present invention also...
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