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Patent # Description
US-9,359,453 Phosphonate and phosphonic acid RAFT agents and monomers, along with methods of their manufacture and use
An intermediate compound for forming a RAFT agent is provided that can have the formula: ##STR00001## where n is an integer from 1 to 20; m is an integer from...
US-9,359,452 Isolation and characterisation of heparan sulphates and their use in pharmaceutical compositions, methods of...
Heparan sulphates isolated from male and female murine liver, their characterisation and use in pharmaceutical compositions, methods of treatment and in stem...
US-9,359,451 Methods and compositions for treating trauma-hemorrhage using estrogen and derivatives thereof
Disclosed are methods and materials for treating or preventing complications due to traumatic injuries using estrogen or derivatives thereof.
US-9,359,450 Process for reducing the amount of water-insoluble fibers in a water-soluble cellulose derivative
The amount of water-insoluble fibers in a water-soluble cellulose derivative is reduced in a process comprising the steps of a) providing a water-soluble...
US-9,359,449 Light-sensitive ion-passing molecules
The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by...
US-9,359,448 Anti-BAFF-anti-IL-17 bispecific antibodies
Bispecific antibodies are provided that specifically bind B-cell Activating Factor of the TNF Family (BAFF) and Interleukin-17A (IL-17) and are characterized as...
US-9,359,447 Anti-mesothelin chimeric antigen receptors
The invention provides a chimeric antigen receptor (CAR) (a) an antigen binding domain of HN1 or SS, a transmembrane domain, and an intracellular T cell...
US-9,359,446 Antibody to a carbonic anhydrase
The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1),...
US-9,359,445 Compositions and methods for treating neurological disorders
The present disclosure provides methods for treating neurological disorders, generally involving modulating protein kinase D1 (PKD1) activity levels in a neuron...
US-9,359,444 Methods and monitoring of treatment with a Wnt pathway inhibitor
Methods for treating diseases such as cancer comprising administering a Wnt pathway inhibitor, either alone or in combination with other anti-cancer agents, and...
US-9,359,443 Combination therapy with anti-CD74 and anti-CD20 antibodies provides enhanced toxicity to B-cell diseases
Disclosed are compositions and methods comprising combinations of anti-CD74 and anti-CD20 antibodies or antigen-binding fragments thereof. The antibody...
US-9,359,442 Anti-CD33 antibodies and methods for treatment of acute myeloid leukemia using the same
The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these...
US-9,359,440 Bispecific chimeric proteins comprising DARPins
A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof,...
US-9,359,439 Fab-glycosylated antibodies
The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates...
US-9,359,438 Human neonatal Fc receptor antibodies and methods of use thereof
The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
US-9,359,437 Antibodies comprising chimeric constant domains
Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence...
US-9,359,436 Generation of a cancer-specific immune response toward MUC1 and cancer specific MUC1 antibodies
The present invention provides a method for inducing a cancer specific immune response against MUC1 using an immunogenic glycopeptide. Other aspects of the...
US-9,359,435 Methods for modulating mannose content of recombinant proteins
The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
US-9,359,434 Cell culture methods to reduce acidic species
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of...
US-9,359,433 FGF modulation of in vivo antibody production and humoral immunity
The invention provides methods for increasing or decreasing antibody production in vivo by inhibiting or promoting the activity of fibroblast growth factor-2...
US-9,359,432 Methods of preventing or treating pain using anti-NGF antibodies that selectively inhibit the association of...
NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor ("NGF"), and methods of treating...
US-9,359,430 Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
The subject invention relates to monoclonal antibodies that may be used in the treatment and diagnosis of Alzheimer's Disease. In particular, the present...
US-9,359,429 Anti-cyanobacteria recombinant antibody polypeptide, gene thereof, and preparation method thereof
Provided are a hybridoma cell CGMCC No. 4783 that secretes a monoclonal antibody of an anti-cyanobacteria cell surface antigen, and the secreted monoclonal...
US-9,359,428 High affinity antibodies that neutralize Staphylococcus enterotoxin B
Provided herein are antibodies that specifically bind and neutralize Staphylococcus enterotoxin B. In addition, nucleic acids encoding such antibodies, and...
US-9,359,427 Methods for culturing human myeloid leukaemia cells and cells derived therefrom
The present invention pertains to a method for culturing a suspension of immortalized human blood cells, preferably cells of myeloid leukaemia origin or cells...
US-9,359,426 Method of preparing low-iron lactoferrin
The present invention relates to methods for producing low-iron Lf having improved antimicrobial activity and to a low-iron Lf having improved antimicrobial...
US-9,359,425 Recombinant T-cell receptor ligand for the treatment of cognitive and neuropsychiatric impairment induced by...
Methods are provided for the treatment of subjects with cognitive or neuropsychiatric impairment induced by substance addiction and for increasing cognitive...
US-9,359,424 Multimeric polypeptides of HLA-G including alpha1-alpha3 monomers and pharmaceutical uses thereof
Multimeric polypeptides and pharmaceutical uses thereof; multimers comprising alpha3 and alpha1 peptides of an HLA-G antigen and methods of producing such...
US-9,359,423 Protein involved in detection of cancer metastasis and a treatment thereof
Using phosphoproteomics, we profiled the phosphorylation levels of hundreds of proteins concurrently across an isogenic model of breast cancer metastasis. Among...
US-9,359,422 Single chain relaxin polypeptides
The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides...
US-9,359,421 Suppressor of the endogenous interferon-gamma
The invention relates to suppressors of endogenous human interferon-gamma (INF-.gamma.) applicable in treatment of diseases associated with impaired activity of...
US-9,359,420 Single chain trail fusion polypeptides and encoding nucleic acids
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules...
US-9,359,419 Treatment of vascular complications of diabetes
A peptide consisting of 7-17 amino acids and including the adjacent hexamer TX.sub.1EX.sub.2X.sub.3E, where X.sub.1, X.sub.2 and X.sub.3 can be any natural or...
US-9,359,418 Inhibitors of the T cell-specific alternative p38 activation pathway and methods of use
In T lymphocytes, p38 mitogen activated protein kinase (MAPK) can be activated through an alternative pathway that involves phosphorylation at tyrosine 323....
US-9,359,417 Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
A cell culture media for plasmid production is provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided herein is a method of...
US-9,359,416 DNA encoding canine monomeric CRP and expression vector containing the DNA
Pentameric CRP is produced at a high efficiency by transferring DNA, which encodes monomeric CRP, into a silkworm to thereby construct a transgenic silkworm and...
US-9,359,415 Ligands modified by circular permutation as agonists and antagonists
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one...
US-9,359,414 Antigenic polypeptides of Trichinella and uses thereof
The invention relates to novel polypeptides which are recognized by anti-Trichinella antibodies. Said polypeptides can be used particularly for detecting...
US-9,359,413 Microorganism and method for the fermentative production of an organic-chemical compound
The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression,...
US-9,359,412 OprF/I fusion proteins, their preparation and use
The present invention relates to a novel trimeric OprF/I fusion protein comprising a portion of the Pseudomonas aeruginosa outer membrane protein F which is...
US-9,359,411 Yeast expressed classical swine fever virus glycoprotein E2 and use thereof
The present invention provides a recombinant yeast system for expressing the glycoprotein E2 of classical swine fever virus (CSFV), in which the expression...
US-9,359,410 Virus like particle purification
Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
US-9,359,409 Antimicrobial peptides, compositions comprising the same and uses thereof
Antimicrobial peptides set forth in SEQ ID Nos: 1-5 are described. The peptides have activity against Gram positive bacteria and against Gram negative bacteria....
US-9,359,408 Fluorinated protein-based polymeric carriers
A biologically derived polymer that facilitates the solubilization and protection of small molecules for use in drug delivery, in which the polymer is a protein...
US-9,359,407 Ehrlichia ewingii proteins, nucleic acids, and methods of their use
The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E....
US-9,359,406 Vaccine for a therapeutic or a prophylactic treatment of myasthenia gravis
A therapeutic composition comprising (1) a complementary peptide comprising a sequence complementary to a major immunogenic region of an acetylcholine receptor...
US-9,359,405 Antagonists of the interleukin-1 receptor
The present invention discloses novel peptides derived from the IL-1 receptor antagonist protein (IL1 RA), capable of binding to the cell surface IL-1 receptor...
US-9,359,404 Methods and products for treating preeclampsia and modulating blood pressure
The invention relates to methods for altering biological parameters in a subject, such as reducing blood pressure in a subject, by displacing CLIP, using a CLIP...
US-9,359,403 Activated collagen scaffold materials and their special fused active restoration factors
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone...
US-9,359,402 EphA2 T-cell epitope agonists and uses therefore
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell...
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