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Patent # Description
US-9,359,401 Peptide analogues with an excellent moisturizing effect and use thereof
The present invention relates to a peptide analog or a pharmaceutically acceptable salt thereof with excellent moisturizing effect, and use thereof for...
US-9,359,400 Site-specific chemoenzymatic protein modifications
The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides...
US-9,359,399 Synthetic peptide amides
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low...
US-9,359,398 Compounds for immunoproteasome inhibition
One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain...
US-9,359,397 Method for manufacturing protein drug
The present invention provides a method for manufacturing a virus-free protein drug, comprising (a) a filtration step of filtering a virus-containing protein...
US-9,359,396 Material for supported synthesis and method for growing oligonucleotides or peptides
The invention concerns a material composed of a porous support on which functionalized nanoparticles are grafted by covalent bonding, characterized in that at...
US-9,359,395 Prodrugs of steroidal CYP17 inhibitors/antiandrogens
Prodrugs of C-17-heterocyclic-steroidal drugs providing improved oral bioavailability and phamacokinetics are described. The drugs are inhibitors of human CYP...
US-9,359,394 Stereoselective glycosylation reactions
Disclosed is a method for selective synthesis of 1,2-cis-.alpha.-linked glycosides which does not require the use of the specialized protecting group patterns...
US-9,359,393 Photoresponsive nucleic acid manufacturing method
The present invention provides a manufacturing method that can easily manufacture a compound known as photoresponsive (photocoupling) nucleic acids at high...
US-9,359,392 Dendrimer scaffolds for pharmaceutical use
This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give...
US-9,359,391 Selective C--O bond cleavage of oxidized lignin and lignin-type materials into simple aromatic compounds
A method to cleave C--C and C--O bonds in .beta.-O-4 linkages in lignin or lignin sub-units is described. The method includes oxidizing at least a portion of...
US-9,359,390 Activated carbon and use therefor
An activated carbon having a high catalytic activity as an oxidation catalyst or a decomposition catalyst, and use therefor are provided. The activated carbon...
US-9,359,389 Caged ceramide-1-phosphate derivatives
The invention relates to novel caged ceramide 1-phosphate (C1P), caged ceramide 1-phosphate derivatives(C1P), and the method of using them for delivering C1P...
US-9,359,388 Transition metal compound having heteroatom, catalystic composition including the same, and method for...
The present invention discloses a transition metal compound having a novel structure and including a heteroatom, a catalyst composition including the same, and...
US-9,359,387 Organosilicon compound having conjugated diene structure and making method
The invention provides a conjugated diene structure-containing organosilicon compound having formula (1): ...
US-9,359,386 Silanes and silicones with distinct hydrophilic and oleophobic substitution
The invention relates to silicon compounds having formula (I): (RfCH.sub.2CH.sub.2).sub.2-n[R(OCH.sub.2CHR').sub.mOR''].sub.nSiX.sub.2 (I). In formula (I), Rf...
US-9,359,385 Preparation of sitagliptin intermediates
The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the...
US-9,359,384 Organohalosilane and use thereof in electrolytes of non-aqueous lithium ion batteries
An organohalosilane represented by formula I, where R.sub.1, R.sub.2, and R.sub.3 independently, at each occurrence, represent --(CH.sub.2).sub.xCH.sub.3 where...
US-9,359,383 .beta.-ketoimine ligand, method of preparing the same, metal complex comprising the same and method of forming...
The .beta.-ketoimine ligand is represented by the following formula 1: ##STR00001## wherein R1 and R2 are each independently a C1-C5 alkyl group. A metal...
US-9,359,382 .beta.-ketoimine ligand, method of preparing the same, metal complex comprising the same and method of forming...
The .beta.-ketoimine ligand is represented by the following formula 1: ##STR00001## wherein R1 and R2 are each independently a C1-C5 alkyl group. A metal...
US-9,359,381 Tricyclic compounds for inhibiting the CFTR channel
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further...
US-9,359,380 DNA-PK inhibitors
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
US-9,359,379 Anti-fibrotic pyridinones
Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.
US-9,359,378 Substituted oxazolo[3,4-a]pyrazines as pharmaceutcals
The present invention relates to novel derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione represented by formula (I): ##STR00001## and a mixture...
US-9,359,377 Substituted imidazo[1,2-a]imidazo[4',5':4,5]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus...
The present invention relates to compounds of formula (I) or salts, racemates, isomers and/or prodrugs thereof useful in the treatment of viral infections, in...
US-9,359,376 Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic...
The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or...
US-9,359,375 Benzamides and nicotinamides as Syk modulators
The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk...
US-9,359,374 Polymorphic forms of rifaximin
Provided for in the instant application are two additional forms of rifaximin, namely rifaximin polymorphic forms APO-III and APO-IV. Also provided are...
US-9,359,373 Lipophilic N-substituted norcantharimide derivatives and uses thereof
Novel N-substituted norcantharimide derivatives are disclosed herein. The novel N-substituted norcantharimide derivatives are useful as lead compounds for...
US-9,359,372 Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof
The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer,...
US-9,359,371 Bicyclic substituted pyrimidine compounds
Disclosed are bicyclic group substituted pyrimidine compounds, pharmaceutical acceptable salts thereof or stereoisomers thereof. Also disclosed are preparation...
US-9,359,370 Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment...
US-9,359,369 Tricyclic sulfonamide compounds and methods of making and using same
The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of...
US-9,359,368 Crystals of dispiropyrrolidine derivatives
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of ...
US-9,359,367 Tetrahydroquinazolinone derivatives as PARP inhibitors
Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R.sup.1-R.sup.6,...
US-9,359,366 Intermediate of Ticagrelor and preparation method therefor, and preparation method for Ticagrelor
Disclosed are intermediates of Ticagrelor and a preparation method therefor, and a preparation method for Ticagrelor. Specifically, disclosed is an...
US-9,359,365 Heterocyclic compounds and uses thereof
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
US-9,359,364 Pharmaceutical formulations, processes, solid forms and methods of use relating to ...
Provided herein are formulations, processes, solid forms and methods of use relating to ...
US-9,359,363 Identification of compounds that disperse TDP-43 inclusions
Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion...
US-9,359,362 Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD
The present invention relates to novel heterocyclically fused diaryldihydropyrimidine derivatives, to processes for their preparation, to their use alone or in...
US-9,359,361 Immune system modulators
The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the...
US-9,359,360 TLR agonists
The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are...
US-9,359,359 Substituted xanthines and methods of use thereof
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
US-9,359,358 Cyclohexyl azetidine derivatives as JAK inhibitors
The present invention provides cyclohexyl azetidine derivatives of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, as well as their...
US-9,359,357 Forms of rifaximin and uses thereof
The present invention relates to Rifaximin amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.
US-9,359,356 Azaadamantane formate ester and process for preparing azaadamantane derivatives
A compound, (4s)-1-azaadamantane-4yl formate ester, is described. In addition, a process is described for preparing (4s)-1-azaadamantane-4yl formate ester,...
US-9,359,355 Fused tricyclic dual inhibitors of CDK 4/6 and FLT3
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions....
US-9,359,354 Kinase inhibitors
Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
US-9,359,353 Nitrogen containing compounds and their use
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. ##STR00001##
US-9,359,352 Substituted benzimidazoles as PI3 kinase inhibitors
The present invention provides substituted benzimidazole compounds of Formula I: ##STR00001## wherein the variables R.sup.1, R.sup.2, W.sup.1, W.sup.2,...
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