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Pre-mix composition for cattle
The present invention concerns a premix composition for feeding cattle, comprising: a) a premix carrier having an overall particle size comprised between 300...
Substituted benzofuran compounds and methods of use thereof for the
treatment of viral diseases
The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds,...
Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase
The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical...
Pharmaceutical composition for preventing or treating cancer, containing
enoblock as active ingredient
The present invention relates to ENOblock, which is a non-substrate analog having an enolase inhibitory activity, and a pharmaceutical composition for...
Use of a receptor-type kinase modulator for treating polycystic kidney
The invention comprises use of a therapeutically effective amount of the compound of the formula below for preparation of a medicament for treating polycystic...
Mutant ROS expression in human cancer
The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins...
Methods of treating a Bruton's Tyrosine Kinase disease or disorder
The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK.
Tablet formulation of a phosphatidylinositol 3-kinase inhibitor
The present invention is directed to compositions and methods that target the PI3K signaling pathway for the treatment or prevention of cancer. In one aspect,...
Method for treatment of neurologic dysfunction
A method for treatment of the symptoms of neurologic dysfunctions, including major depression, an autism spectrum disorder (ASD), and schizophrenia. The patient...
Methods for treating pancreatic cancer using combination therapies
comprising liposomal irinotecan
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional...
Amino, Amido and heterocyclic compounds as modulators of RAGE activity and
Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
Compositions and methods of treating retinal disease
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin,...
Methods for treating disorders or diseases associated with hyperlipidemia
and hypercholesterolemia while...
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an...
Identification of a new AMPK activator for treatment of lung cancer
The present invention discloses a method of treating gefitinib-resistant non-small-cell lung cancer, comprising administering an effective amount of D561-0775....
Pharmaceutical composition for preventing or treating tuberculosis
The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a...
Rifaximin derivative and uses thereof
25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof is provided. Methods of treatment of bowl related disorders using isolated and/or purified...
Heterocyclic compounds as protein kinase inhibitors
The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof,...
Thiazolidinediones of omega-3 polyunsaturated acids as new insulin
sensitizers for treating type2 diabetes
The present invention relates to thiazolidinedione derivatives of omega-3 fatty acids as insulin sensitizers, and their use in treating Type2 diabetes, obesity,...
Compositions and methods for treating extracellular parasitic infections
There is disclosed herein a composition for treating extracellular parasitic infections, the composition comprising one or more of the following combinations:...
Use of amino acid supplementation for improved muscle recovery
The present invention encompasses an amino acid composition for recovery of muscle strength and function.
Alpha-1-adrenergic receptor agonist therapy
Presented herein inter alia are novel methods of treating heart and brain diseases.
Process for manufacturing ophthalmic oil-in-water emulsions
The present invention relates to new processes for the preparation of oil-in-water emulsions useful in ophthalmic applications. In particular, processes are...
PKC delta inhibitors for use as therapeutics
The invention is directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevention of cancers and...
3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the
treatment of colon and gastric...
The present invention relates to the use of a compound of formula (I) wherein R.sup.1 and R.sup.3 are as defined in the description and R.sup.2 is a phenyl...
Stabilized pharmaceutical dosage forms comprising atrasentan
The present disclosure relates to: (a) stabilized pharmaceutical dosage forms comprising atrasenstan, or a pharmaceutically acceptable salt thereof, and,...
Method for manufacturing composition for lowering blood lipid and
elevating high-density lipoprotein
The present invention discloses a composition for lowering blood lipid and elevating high-density lipoprotein and a method for manufacturing the same; the...
Ketone esters for treatment of angelman syndrome
The invention concerns a method of treating Angelman Syndrome (AS) in a subject, comprising inducing ketosis in the subject by administering a therapeutically...
Combination of a prostaglandin receptor agonist and an MC1R receptor
agonist for the treatment and/or...
A combination of compounds is described for the treatment and/or prevention of skin conditions linked to hypopigmentation. Also described, is a combination...
Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its
The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.
Method of treating postural reflex abnormality caused by parkinson's
The present disclosure relates to a more effective therapeutic agent capable of improving and treating the axial symptoms (particularly freezing of gait...
Pharmaceutical composition for preventing or treating hepatic fibrosis and
cirrhosis containing ramalin
There is provided a novel use of ramalin for preventing or treating liver diseases, and more specifically, a pharmaceutical composition for preventing or...
Alternating sympathomimetic therapy for the treatment of respiratory
A combination of dosage units for alleviating respiratory ailments and a method of alleviating respiratory ailments which uses this combination of dosage units....
Clenbuterol for use in treatment of autism
Clenbuterol or its salt for use in the treatment of autism, in particular pediatric autism. Improved contact with surroundings, better concentration, improved...
Peptoid and synthetic oligomers, pharmaceutical compositions and methods
of using same
Novel peptide/peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: ##STR00001## The peptide/peptoid oligomers...
Nitisinone for treatment of oculocutaneous/ocular albinism and for
A method is provided for the treatment of vision problems in a subject suffering from one of various forms of albinism, including, for example, oculocutaneous...
Compositions for treating or preventing cardiovascular disease
Vitamin K is effective in counteracting cardiovascular disorders such as the reduction in arterial elasticity normally associated with the aging process. A...
Stabilized compositions containing alkaline labile drugs
A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a...
Functional PLA-PEG copolymers, the nanoparticles thereof, their
preparation and use for targeted drug delivery...
Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging The present invention concerns novel...
Compositions and methods for drug delivery
The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle...
Biodegradable phase separated segmented multi block co-polymers and
release of biologically active polypeptides
The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in...
Rotary die system
A rotary die system that includes first and second axially aligned, coacting rotary dies positioned adjacent one another. Each die includes a working surface...
Delayed release drug formulation
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug...
Pharmaceutical compositions for the coordinated delivery of NSAIDs
The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a...
Process for producing solid particles
A method of producing crystal of a poorly water-soluble pharmaceutical compound, including mixing a solution of a poorly water-soluble pharmaceutical compound...
Diaminooxidase-containing pharmaceutical compositions
The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use...
High capacity diketopiperazine microparticles and methods
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine ...
Lipid formulations for nucleic acid delivery
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles,...
Method for making nanolipidic particles
Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger...
Parenteral formulations of lipophilic pharmaceutical agents and methods
for preparing and using the same
There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous...
Intraventricular drug delivery system for improving outcome after a brain
injury affecting cerebral blood flow
The described invention provides a flowable sustained release microparticulate composition, a kit for treating at least one cerebral artery in a subarachnoid...