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Amplification system with spatial separation
An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is...
Methods and kits for avoiding amplification of contaminating nucleic acids
A method of amplifying a nucleic acid of interest comprises (i) treating a biological sample chemically or enzymatically to permit conversion of one type of...
Methods of mapping polymorphisms and polymorphism microarrays
Described are methods for the high-throughput discovery and genotyping of nucleotide polymorphisms in DNA, including single nucleotide polymorphism (SNPs) and...
Screening method for trinucleotide repeat sequences
A method for screening for a trinucleotide repeat sequence in a biological sample is provided. The method comprises the step of contacting a nucleic acid...
Nucleic acid analysis device, method for producing same, and nucleic acid
Disclosed is a technique for binding microparticles to patterned bonding pads of a metal (e.g., gold) formed on a support. The microparticles each carry a...
Solid medium for the storage of biological material
This invention relates to flat solid media for the storage of samples of biological materials and methods of analyzing biomolecules contained within the samples...
PON1 as a marker for heart failure
Provided herein are methods for assessing the risk a test subject with heart failure has of experiencing a major adverse cardiac event, requiring...
Assessing the risk of a major adverse cardiac event in patients with chest
Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting to an Emergency Department with chest pain...
Rational enzyme mining
A method for rational mining for induced enzymes in microbial communities is described. The method is characterized in that a community of microorganisms is...
Device for standardising the in-vitro synergy testing of two antibiotics
through the method crossing the...
A device for microbiological analyzes is provided. More specifically, a device is provided for standardizing the crossing and allowing a perfect angle of...
High-throughput complement-mediated antibody-dependent and opsonic
The disclosure provides methods and kits for performing automated high-throughput assays to measure bactericidal activity in samples, such as plasma or sera...
Environmental evaluation installation and environmental evaluation method
An environmental evaluation installation including an evaluation chamber 1 isolated from outer space by isolation walls 2, minute substance supply means 3...
Spectroscopic means and methods for identifying microorganisms in culture
A spectroscopic method for spectroscopic detection and identification of bacteria in culture is disclosed. The method incorporates construction of at least one...
Immobilization support, process for producing the same, electrode, process
for producing the same, electrode...
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an...
Process for antibody G1 glycoform production
The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment or immunoglobulin fusion with G1 glycostructure comprising...
Fermentation process for the production of rapamycin
The present invention provides a novel method for producing rapamycin by submerged fermentation which comprises cultivating Streptomyces hygroscopicus (CBS...
UK-2 biosynthetic gene and method for improving UK-2 productivity using
The genomic DNA of Streptoverticillium sp. 3-7, which produces UK-2, was analyzed to identify a region expected to be a UK-2 biosynthetic gene cluster....
Biocatalytic process for preparing eslicarbazepine and analogs thereof
The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
Preparation of process of L-methionine
The present invention relates to a method for producing L-methionine using a bio-synthesis process and a specific enzymatic process. More particularly, the...
Method for producing chemical by continuous fermentation
A method produces a chemical through continuous fermentation including: (a) culturing a cell in a culture medium in a fermentor to ferment a feedstock to...
3-hydroxypropionic acid production by recombinant yeasts
Provided herein are recombinant yeast cells having an active 3-Hydroxypropionic Acid (3-HP) pathway and further comprising a heterologous polynucleotide...
Methods for synthesis of olefins and derivatives
The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a...
Genetically engineered bacterium with altered carbon monoxide
dehydrogenase (CODH) activity
The invention provides genetically engineered microorganisms with altered carbon monoxide dehydrogenase (CODH) activity and methods related thereto. In...
Fermentive production of four carbon alcohols
Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth...
Method of using .alpha.-amylase from Aspergillus clavatus for
A fungal .alpha.-amylase is provided from Aspergillus clavatus (AcAmy1). AcAmy1 has an optimal pH of 4.5 and is operable at 30-75.degree. C., allowing the...
Integrated processes for anaerobic conversion of hydrogen and carbon
oxides to alcohol
Integrated processes are disclosed for reducing the carbon foot print related to the use of non-renewable hydrocarbon gas streams for producing alcohols by...
Process for producing alcohol by fermentation of sugars
A process for increasing a production of alcohol by fermenting sugars may include applying a direct current electrical field to a fermentation broth, which...
Fermentation process for producing isopropanol using a recombinant
The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation...
Protein and nucleic acid delivery vehicles, components and mechanisms
Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful...
Vectors for generating pluripotent stem cells and methods of producing
pluripotent stem cells using the same
A reprogramming gene-loaded Sendai viral vector comprising Sendai virus genes and reprogramming genes, wherein the Sendai virus genes include an NP gene, P/C...
Vector utilizing borna disease virus and use thereof
Disclosed is a viral vector comprising (a) a cDNA of a recombinant viral RNA having at least the N gene, the X gene, the P gene, and the L gene of a Borna...
Meganuclease recombination system
The invention relates to a set of genetic constructs which allow the efficient and reproducible introduction of a specific nucleotide sequence at a fixed...
Compositions and methods for deploying a transgenic refuge seed blend
Methods and compositions for deploying refuge seeds with transgenic crop seeds comprising event MON 87411 are provided. The refuge seeds can be non-transgenic...
Herbicide resistant sorghum mutants
This disclosure provides for four different sorghum mutants that exhibit resistance to ALS-inhibiting herbicides. This disclosure also provides for methods of...
Truncated alternan sucrase coding nucleic acid molecules
The present invention relates to nucleic acid molecules which code for a truncated alternan sucrase. The invention further relates to truncated alternan...
Mutagenesis method using polyethylene glycol mediated introduction of
mutagenic nucleobases into plant protoplasts
Method for targeted alteration of a duplex acceptor DNA sequence in a plant cell protoplast, comprising combining the duplex acceptor DNA sequence with a donor...
Use of non-agrobacterium bacterial species for plant transformation
The invention relates to methods for Rhizobia-mediated genetic transformation of plant cells, including soybean, canola, corn, and cotton cells. These include...
Method of transforming cells
Use of an isolated Ensifer adhaerens strain OV14 deposited under NCIMB Accession Number 4177, or an isolated variant thereof characterized by a 16S rRNA gene...
Xylose isomerase and xylitol dehydrogenase combination for xylose
fermentation to ethanol and B. fragilis...
Disclosed herein is a newly discovered problem and solution for engineering S. cerevisiae to ferment xylose to make ethanol utilizing xylose isomerase to...
Methods of using a serum response factor isoform
The present invention encompasses methods of administering SRF.DELTA.3. Administering SRF.DELTA.3 may reduce proliferation of cancer cells, and modulate...
Aptamers to 4-1BB and their use in treating diseases and disorders
The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to 4-1BB; pharmaceutical...
LAR protein-specific ligand
The present invention relates to an aptamer comprising a nucleic acid comprising, or consisting of: --the sequence ACUGU CCCAG UAUGA CGCGA CUGCU UAGGU GGGAU...
Matriptase inhibitors and uses thereof against orthomyxoviridae infections
The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present...
Compositions and methods related to miRNA modulation of neovascularization
The present invention concerns methods and compositions for diagnosing and/or treating vascular diseases including cancer, cardiac diseases, vascular diseases...
Spalt-like transcription factor 4 (SALL4) and uses thereof
Described are methods of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an...
Methods and compositions for the specific inhibition of MYC by
This invention relates to compounds, compositions, and methods useful for reducing MYC target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate...
Methods and compositions for the specific inhibition of gene expression by
The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating...
Modulation of apolipoprotein C-III expression
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to...
Accelerated directed evolution of microbial consortia for the development
of desirable plant phenotypic traits
The disclosure relates to methods for the screening, identification, and/or application of one or more microorganisms of use in imparting one or more beneficial...
Surface, anchored Fc-bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. A bait complexed with a monovalent...