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Methods and compositions for targeting polyubiquitin
Anti-K63-linked polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.
Compositions and methods for targeting stromal cells for the treatment of
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a...
Methods for the treatment of cancer and inflammatory diseases using
cereblon as a predictor
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
Antibody molecules to dengue virus and uses thereof
Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1,...
Antibodies against human respiratory syncytial virus (RSV) and methods of
Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV)....
Antiviral agent, abzyme, primer set, method for producing polynucleotide,
and method for producing polypeptide
The present invention provides: a novel antiviral agent containing a human antibody .kappa. light chain, a novel human abzyme containing a human antibody...
Human cytomegalovirus neutralizing antibodies and use thereof
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody...
Intravenous immunoglobulin composition
A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a...
Aprotinin-like polypeptides for delivering agents conjugated thereto to
Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the...
Peptide preparations and peptides with antitumour activity
The subject of the present invention are peptide preparations obtained via the enzymatic digestion of hair, wool, bristles, animal fur and individual peptides...
Exendin-4 derivatives as dual GLP1/glucagon agonists
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
Method of increasing natriuretic activity by administering natriuretic
polypeptides with unique pharmacologic...
This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide...
Compositions and methods for Immunomodulation in an organism
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need...
Designed armadillo repeat proteins
The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them....
Opsin polypeptides and methods of use thereof
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
Endomucin as an anti-inflammatory agent
The invention provides compositions and methods for utilizing endomucin as an anti-inflammatory agent.
The present invention includes a novel protein, also referred to herein as simukunin, that inhibits the function of several physiologically important enzymes....
Bacterial methionine analogue and methionine synthesis inhibitor
anticancer, antiinfective and coronary heart...
A substantially purified substance having the properties of a bacterial microcin methionine analog, methionine synthesis inhibitor, tRNA-methionine synthase...
Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said...
Genetically-engineered cyanochrome fluorophore molecules (fluorophores) with increased fluorescence and with absorbing fluorescence in the blue and green...
Methods and compositions related to cyclic peptide synthesis
Disclosed are compositions and methods for cyclization of polymers such as peptides.
Method for preventing neoplastic transformation by inhibition of
retinoblastoma protein inactivation
A method for preventing neoplastic transformation by inhibition of cell cycle progression into S phase by preventing the inactivation of Retinoblastoma protein...
Methods for treating pain
The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is...
IgG-binding peptide and method for detecting and purifying IgG using same
Provided is a peptide that specifically or selectively binds to human IgG. This peptide comprises an amino acid sequence consisting of 13 to 17 amino acid...
Synthetic peptide that induces expression of TNF receptor 2 and use
This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a...
Activated collagen scaffold materials and their special fused active
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone...
Use of endostatin peptides for the treatment of fibrosis
C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and...
Cross-linked peptides containing non-peptide cross-linked structure,
method for synthesizing cross-linked...
The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing...
IAP BIR domain binding compounds
A compound of Formula I ##STR00001## or a salt thereof, methods for the preparation thereof, and related methods and compositions.
Acylated 4-amidino- and -4-guanidinobenzylamines for inhibition of plasma
The invention relates to the use of acylated 4-amidino- or 4-guanidinobenzylamine in accordance with the general formula I P4-P3-P2-P1 (I), where P4 is a...
A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I: X--W wherein X is a caspase-selective structure and W has the structure of...
19-NOR neuroactive steroids and methods of use thereof
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are...
Asymmetric ionizable cationic lipid for RNA delivery
What is described is a compound of formula I ##STR00001## wherein R.sub.1 consists of a linear or branched alkyl consisting of 1-18 carbons, an alkenyl or...
Process for preparing a crystalline form of halobetasol propionate
The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate...
Method for treating diabetes
This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites,
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated...
Synthesis of protected 3'-amino nucleoside monomers
Orthogonally protected 3'-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the...
Cyclic nucleotide analogs
Disclosed herein are cyclic nucleotide analogs, methods of synthesizing cyclic nucleotide analogs and methods of treating diseases and/or conditions such as...
Oligomer-nucleoside phosphate conjugates
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water soluble, non-peptidic oligomer. The conjugates of the...
Method for producing myo-inositol and myo-inositol derivative
[Problem] To impart significantly improved myo-inositol producing capability, suitable for use in recombinant DNA techniques and synthetic biology methods, to a...
Sodium glucose co-transporter inhibitors and methods of their use
Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such...
1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate) and the
The present invention describes the dihydrate of 1,2-cyclohexanediaminplatinum(II)-bis-(4-methylbenzenesulfonate), a method for producing ...
Polynuclear metal clusters, methods of making, and methods of use thereof
Embodiments of the present disclosure provide for polynuclear manganese cluster compounds, methods of making, methods of use, method of producing hydrogen and...
N.sub.3S.sub.1 chelator-folate derivatives, preparation method thereof and
composition for diagnosis or...
Novel N.sub.3S.sub.1 chelator-folate derivatives, a preparation method thereof, and a composition for diagnosis and treatment of tumor including the same as an...
Phosphine derivatives of fluorescent compounds
A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in...
Mitochondria-targeted inhibitors of cytochrome c peroxidase for protection
The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group,...
Method for preparing quaternary phosphonium salts
A two-step pathway for preparing high pure quaternary phosphonium salts is disclosed. In the first step, hydrogen phosphide (PH.sub.3) or a higher phosphine...
Method of converting polyhedral oligomeric silsesquioxane (POSS) type T8
into type 10
The conversion method of T.sub.8 type Polyhedral Oligomeric Silsesquioxanes (POSS) into T.sub.10 type compounds, includes treating octasilsesquioxane of the...
Enhanced substantivity of cosmetic ingredients on keratinous substrate
The invention provides compositions and methods for reversible covalent binding of benefit agents to keratinous substrates through the reaction of a dicarbonyl...
Photolabile caged transition metal complexes and methods of using the same
The present invention provides compounds of Formula I: ##STR00001## along with compositions comprising the same and methods of using the same, such as for...